Results 131 to 140 of about 1,788,718 (217)

Multimodal Phytochemical and Micronutrient Profiling of <i>Onosma onur-koyuncui</i> Sezer Seeds: Antioxidant and Enzyme Activity Inhibitory Potential. [PDF]

Antioxidants (Basel)
Öğüt K, Troncoso AM, García-Parrilla MDC, Özek G, Sezer O, Özek T.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

ADA2 genotype and enzyme activity may predict vasculitic or hematologic DADA2 phenotype. [PDF]

J Hum Immun
Peters P, Schepp J, Albert MH, von Bernuth H, Blank N, Brunner J, Dückers G, Ehlers L, Farmand S, Föll D, Förster-Waldl E, Gburek-Augustat J, Ghosh S, Göschl L, Hömberg M, Hönig M, Kallinich T, Klemann C, Klingel L, Kontny U, Kuhn LM, Lamprecht P, Lehmberg K, Meyer-Bahlburg A, Müller I, Nathrath M, Niehues T, Oommen PT, Pachlopnik Schmid J, Prader S, Puzik A, Renella R, Schulz A, Skrabl-Baumgartner A, Starke S, Tarrant TK, Hershfield M, Grimbacher B, Hauck F.   +38 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Regulation of Microenvironments of Hydrogen-Bonded Organic Frameworks for Enhanced Enzyme Activity of Phosphotriesterase. [PDF]

Molecules
Wu F, Li P, Guo Y, Du C, Li P.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Digestive Enzyme Activity and Temperature: Evolutionary Constraint or Physiological Flexibility? [PDF]

Animals (Basel)
Sagonas K, Paraskevopoulou F, Kotsakiozi P, Sozopoulos I, Pafilis P, Valakos ED.   +5 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Case Report: Concurrent Fabry disease, IgA nephropathy and undifferentiated connective tissue disease in a female with normal enzyme activity. [PDF]

Front Immunol
Cui A, Ma S, Sun T, Chang M, Lu S, Fu S, Xu H.   +6 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source