Results 151 to 160 of about 1,754,066 (244)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Life on the rocks: unexpected enzyme activity of the extremophilic black fungus Knufia chersonesos. [PDF]

Front Bioeng Biotechnol
Mihalyi S, Zimmermann C, Quartinello F, Tesei D, Mach-Aigner AR, Guebitz G, Ribitsch D.   +6 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

How manure amendment counters no-tillage yield reduction in winter wheat: enhanced nitrogen components and soil enzyme activity. [PDF]

Front Plant Sci
Mi W, Wang S, Zhang J, Zhao G, Dang Y, Wang L, Zhou G, Zhou X, Hu J, Li S, Gong D, Fan T.   +11 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Mussels enhance digestive enzyme activity in preparation for stressful fluctuating environments. [PDF]

J Comp Physiol B
James Bond JA, Escobar PI, Hood NZ, Hong HC, Rankins DR, Chan G, Betancourt JV, Brocco French K, Procter ND, Wehrle BA, Connor KM.   +10 more
europepmc   +1 more source

ACTIVATION OF ENZYMES

Journal of Biological Chemistry, 1934
Leslie Hellerman, Marie E. Perkins
openaire   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Elevated lysosomal mass and enzyme activity in fibroblasts of the Mediterranean mouse Mus spretus. [PDF]

Biol Lett
Sui M, Teh J, Fort KA, Shaw DE, Sudmant PH, Koide T, Good JM, Vazquez JM, Brem RB.   +8 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source