Results 141 to 150 of about 1,788,718 (217)

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity. [PDF]

Elife
Mancl JM, Liang WG, Bayhi NL, Wei H, Budell WC, Mendez JH, Sosnick TR, Carragher B, Potter CS, Potter CS, Tang WJ.   +10 more
europepmc   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Effects of biochar-based amendments on enzyme activity, microbial biomass, and bacterial communities in mildly cadmium-contaminated paddy soils. [PDF]

Front Microbiol
Han J, Yang H, Huang B, Shi Y, Peng W, Zeng W, Wang J, Wu D, Zhu A.   +8 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Validating a Human Cell Model of Null Galactosylceramidase (GALC) Enzyme Activity That Recapitulates Krabbe Disease. [PDF]

J Inherit Metab Dis
Starosta RT, Khatoon N, Roberts MS, Le SQ, Austin G, Cui X, Strout G, Schmidt RE, Jiang X, Sands MS, Dickson PI.   +10 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

EnzyDiff: Sequence-based classification of mutation-induced enzyme activity direction using latent diffusion denoising. [PDF]

Sci Prog
Jin H, Liu Z, Jia Z.
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Nonequilibrium phases of a biomolecular condensate facilitated by enzyme activity.

Soft Matter
Coupe S, Fakhri N.
europepmc   +1 more source

Changes in Water Dynamics by Osmolytes Regulate Enzyme Activity. [PDF]

J Phys Chem B
Furukawa S, Hishida M.
europepmc   +1 more source