Results 41 to 50 of about 1,624,448 (258)

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Sanschagrin, François, Tom Clarke, Catherine Paradis-Bleau, Blewett, Ann, Roger C Levesque, Clark, Tom, Paradis-Bleau , Catherine, Ann Blewett, Adrian Lloyd, Levesque, Roger C., Lloyd, Adrian, François Sanschagrin, Timothy DH Bugg, Bugg, Tim   +13 more
core   +1 more source

Role of Serine 310 in the Activity and Temperature Profile of Human Caspase-9

مجله علمی دانشگاه علوم پزشکی کردستان, 2023
Background and Aim: Caspase-9 is a key enzyme in the intrinsic pathway of apoptosis that its activity is regulated by various mechanisms such as phosphorylation.
Raheleh Shakeri, Mohadeseh Mahmoudian, Reza Khodarahmi, Soheila Mohammadi   +3 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assay of proteolytic enzyme(s) from Neurospora crassa [PDF]

, 1965
Assay of proteolytic enzyme(s) from Neurospora ...
Drysdale, R. B., Fling, M., R. B. Drysdale, M. Fling   +3 more
core   +1 more source

Characterization of monoclonal and polyclonal antibodies to bovine enteric coronavirus: Establishment of an efficient ELISA for antigen detection in feces [PDF]

, 1989
Monoclonal antibodies to bovine enteric coronavirus (BEC) were produced. Additionally, polyclonal antibodies were made in rabbits and guinea pigs and extracted from the yolk of immunized hens.
Eichhorn, Werner, Czerny, C. P.
core   +1 more source

Chia (Salvia hispanica) Seed Oil Modulates the Haemato-Immunological Response, Antioxidative Status and Cytokine Gene Expression of Tropical Freshwater Teleost, Labeo rohita

Biology
The present investigation attempts to evaluate the impact of the dietary inclusion of chia (Salvia hispanica) seed oil (CSO) on the indices of haemato-immunology, metabolic enzymes, and expression of immune-responsive cytokine genes in Labeo rohita (rohu)
Sanjay Kumar Gupta, Rajan Gupta, Akruti Gupta, Md Javed Foysal, Kishore Kumar Krishnani   +4 more
doaj   +1 more source

Methylglyoxal Detoxification Revisited: Role of Glutathione Transferase in Model Cyanobacterium Synechocystis sp. Strain PCC 6803

mBio, 2020
Methylglyoxal (MG) is a detrimental metabolic by-product that threatens most organisms (in humans MG causes diabetes). MG is predominantly detoxified by the glyoxalase pathway.
Xavier Kammerscheit, Arnaud Hecker, Nicolas Rouhier, Franck Chauvat, Corinne Cassier-Chauvat   +4 more
doaj   +1 more source

Smartphone-Based Chemiluminescent Origami µPAD for the Rapid Assessment of Glucose Blood Levels

Biosensors, 2021
Microfluidic paper analytical devices (µPADs) represent one of the most appealing trends in the development of simple and inexpensive analytical systems for diagnostic applications at the point of care (POC).
Donato Calabria, Martina Zangheri, Ilaria Trozzi, Elisa Lazzarini, Andrea Pace, Mara Mirasoli, Massimo Guardigli   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source