Results 31 to 40 of about 1,285,868 (304)

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]

, 2014
To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel, Annaert, Pieter, Boussery, Koen, Colin, Pieter, Cuyckens, Filip, Mannens, Geert, Snoeys, Jan, T'jollyn, Huybrecht, Van Bocxlaer, Jan, Van Peer, Achiel, Vermeulen, An   +10 more
core   +1 more source

Uncultured Microbial Phyla Suggest Mechanisms for Multi-Thousand-Year Subsistence in Baltic Sea Sediments

mBio, 2019
Energy-starved microbes in deep marine sediments subsist at near-zero growth for thousands of years, yet the mechanisms for their subsistence are unknown because no model strains have been cultivated from most of these groups.
Jordan T. Bird, Eric D. Tague, Laura Zinke, Jenna M. Schmidt, Andrew D. Steen, Brandi Reese, Ian P. G. Marshall, Gordon Webster, Andrew Weightman, Hector F. Castro, Shawn R. Campagna, Karen G. Lloyd   +11 more
doaj   +1 more source

Total tissue lactate dehydrogenase activity in endometrial carcinoma [PDF]

, 2008
Lactate dehydrogenase (LDH) is essential for continuous glycolysis necessary for accelerated tumor growth. The aim of this study was to reconsider if assay of total tissue activity of this enzyme could be useful as marker for endometrial carcinoma (EC ...
Abramić, Marija, Babić, Damir, Ilić-Forko, Jadranka, Osmak, Maja, Šimaga, Šumski   +4 more
core   +1 more source

Current State of the Art of Newborn Screening for Lysosomal Storage Disorders

International Journal of Neonatal Screening, 2018
Prospective full-population newborn screening for multiple lysosomal storage disorders (LSDs) is currently practiced in a few NBS programs, and several others are actively pursuing this course of action.
David S. Millington, Deeksha S. Bali
doaj   +1 more source

Solvent and thermal stability, and pH kinetics, of proline-specific dipeptidyl peptidase IV-like enzyme from bovine serum [PDF]

, 2007
Proline-specific dipeptidyl peptidase-like (DPP IV; EC 3.4.14.5) activity in bovine serum has attracted little attention despite its ready availability and the paucity of useful proline-cleaving enzymes.
Abbott, Barry, Brendan F. O’Connor, Buckley, Bušek, Chruscinska, Ciarán Ó’Fágáin, De Meester, Deborah M. Ruth, Demuth, Dixon, Duke-Cohan, Dunn, Durinx, Edens, Engel, Fersht, FitzGerald, Gonzalez, Gorren, Grasso, Jagath, Khmelnitsky, Kikkawa, Lambeir, Lee, Maes, Mentlein, Mittal, Ogino, Ohkubo, Ohnishi, O’Cuinn, Poltorak, Poltorak, Rasmussen, Sears, Sentandreu, Sheehan, Smith, Séamus J. Buckley, Trubetskoy, Yaron, Yoshimoto   +43 more
core   +1 more source

Screening natural product extracts for potential enzyme inhibitors: protocols, and the standardisation of the usage of blanks in α-amylase, α-glucosidase and lipase assays

Plant Methods, 2021
Background Enzyme assays have widespread applications in drug discovery from plants to natural products. The appropriate use of blanks in enzyme assays is important for assay baseline-correction, and the correction of false signals associated with ...
Chintha Lankatillake, Shiqi Luo, Matthew Flavel, George Binh Lenon, Harsharn Gill, Tien Huynh, Daniel Anthony Dias   +6 more
doaj   +1 more source

Specificity and Kinetics of Haloalkane Dehalogenase [PDF]

, 1996
Haloalkane dehalogenase converts halogenated alkanes to their corresponding alcohols. The active site is buried inside the protein and lined with hydrophobic residues. The reaction proceeds via a covalent substrate-enzyme complex.
Janssen, Dick B.,, Kingma, Jaap,, Schanstra, Joost P.,   +2 more
core   +5 more sources

Enzyme Immunoassay and Enzyme-Linked Immunosorbent Assay [PDF]

Journal of Investigative Dermatology, 2013
inTrOducTiOn Enzyme immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA) are both widely used as diagnostic tools in medicine and as quality control measures in various industries; they are also used as analytical tools in biomedical research for the detection and quantification of specific antigens or antibodies in a given sample. These two
Gan, Stephanie D., Patel, Kruti R.
openaire   +2 more sources

Mass spectrometry—based metabolomics, analysis of metabolite-protein interactions, and imaging

BioTechniques, 2010
Our understanding of biology has been greatly improved through recent developments in mass spectrometry, which is providing detailed information on protein and metabolite composition as well as protein-metabolite interactions.
Do Yup Lee, Benjamin P. Bowen, Trent R. Northen   +2 more
doaj   +1 more source

Optimisation of the enzyme-linked lectin assay for enhanced glycoprotein and glycoconjugate analysis [PDF]

, 2011
Lectin’s are proteins capable of recognising and binding to specific oligosaccharide tructures found on glycoproteins and other biomoloecules. As such they have found tility for glycoanalytical applications.
Afrough, Aileen Creavin, Ambrosi, Andrews, Brendan O’Connor, Campbell, Charlwood, Chen, Debray, Drickamer, Duk, Dwek, Eisen, Geyer, Guile, Harvey, Hsu, Huber, Iskratsch, Jiménez-Barbero, Karamanska, Karlsson, Kim, Kirkeby, Kristiansen, Laemmli, Lis, Loris, Michael O’Connell, North, Olausson, Paul Clarke, Pilobello, Pilobello, Raman, Roisin Thompson, Rosenfeld, Royle, Rudd, Rudd, Rudd, Sparbier, Studentsov, Trimble, Varki, Wu, Wu, Wu, Wu   +48 more
core   +2 more sources