Results 1 to 10 of about 631,762 (309)
Mechanistically Coupled PK (MCPK) Model to Describe Enzyme Induction and Occupancy Dependent DDI of Dabrafenib Metabolism [PDF]
Pharmaceutics, 2022 Dabrafenib inhibits the cell proliferation of metastatic melanoma with the oncogenic BRAF(V600)-mutation. However, dabrafenib monotherapy is associated with pERK reactivation, drug resistance, and consequential relapse. A clinical drug-dose determination
Marco Albrecht +3 more
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Induction of bacterial enzymes [PDF]
Biochemical Journal, 1972 Patricia H. Clarke
openaire +4 more sources
Enhancing enzyme activity of heterologously expressed Chit42 in Nicotiana benthamiana for chitin degradation [PDF]
Biotechnology ReportsThis study focused on enhancing the activity of the chitinase42 enzyme from Trichoderma atroviride. A Chitin-Binding Domain (ChBD) from T. atroviride chitinase18.10 was incorporated into the genomic DNA of the chitinase42 at the N-terminal using SOEing ...
Naser Mirhosseini Motlagh +3 more
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Induction and Characterisation of Lignocellulolytic Activities from Novel Deep-Sea Fungal Secretomes
Fermentation, 2023 Fungi are increasingly recognised as being able to inhabit extreme environments. The deep sea is considered an extreme environment because of its low temperatures, high hydrostatic and lithostatic pressures, 3.5% salinity, and low oxygen, nutrient and ...
Bronwyn Dowd, Maria G. Tuohy
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Cells, 2020 Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity.
Philip Marx-Stoelting +2 more
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Acta Scientiarum: Biological Sciences, 2015 Studies on new microbial sources of cellulase and accurate assessment of the steps that increase cellulase production are essential strategies to reduce costs of various processes using such enzymes.
Genilton da Silva Faheina Junior +5 more
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Modeling of rifampicin-induced CYP3A4 activation dynamics for the prediction of clinical drug-drug interactions from in vitro data. [PDF]
PLoS ONE, 2013 Induction of cytochrome P450 3A4 (CYP3A4) expression is often implicated in clinically relevant drug-drug interactions (DDI), as metabolism catalyzed by this enzyme is the dominant route of elimination for many drugs.
Fumiyoshi Yamashita +7 more
doaj +1 more source
Molecules, 2017 Seven medicinal plants popularly used for treating malaria in West Africa were selected to assess herb-drug interaction potential through a series of in vitro methods.
Pius S. Fasinu +5 more
doaj +1 more source