Results 1 to 10 of about 2,923,477 (171)

ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON [PDF]

open access: greenProceedings of the National Academy of Sciences of the United States of America, 1957
Aaron Novick, Milton A. Weiner
openalex   +2 more sources

Induction and Characterisation of Lignocellulolytic Activities from Novel Deep-Sea Fungal Secretomes

open access: yesFermentation, 2023
Fungi are increasingly recognised as being able to inhabit extreme environments. The deep sea is considered an extreme environment because of its low temperatures, high hydrostatic and lithostatic pressures, 3.5% salinity, and low oxygen, nutrient and ...
Bronwyn Dowd, Maria G. Tuohy
doaj   +1 more source

Mechanistically Coupled PK (MCPK) Model to Describe Enzyme Induction and Occupancy Dependent DDI of Dabrafenib Metabolism

open access: yesPharmaceutics, 2022
Dabrafenib inhibits the cell proliferation of metastatic melanoma with the oncogenic BRAF(V600)-mutation. However, dabrafenib monotherapy is associated with pERK reactivation, drug resistance, and consequential relapse. A clinical drug-dose determination
Marco Albrecht   +3 more
doaj   +1 more source

The Connection of Azole Fungicides with Xeno-Sensing Nuclear Receptors, Drug Metabolism and Hepatotoxicity

open access: yesCells, 2020
Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity.
Philip Marx-Stoelting   +2 more
doaj   +1 more source

Strategies to increase cellulase production with submerged fermentation using fungi isolated from the Brazilian biome

open access: yesActa Scientiarum: Biological Sciences, 2015
Studies on new microbial sources of cellulase and accurate assessment of the steps that increase cellulase production are essential strategies to reduce costs of various processes using such enzymes.
Genilton da Silva Faheina Junior   +5 more
doaj   +1 more source

Controversies in contraception for women with epilepsy

open access: yesAnnals of Indian Academy of Neurology, 2015
Contraception is an important choice that offers autonomy to women with regard to prevention of unintended pregnancies. There is wide variation in the contraceptive practices between continents, countries, and societies.
Sanjeev V Thomas
doaj   +1 more source

Modeling of rifampicin-induced CYP3A4 activation dynamics for the prediction of clinical drug-drug interactions from in vitro data. [PDF]

open access: yesPLoS ONE, 2013
Induction of cytochrome P450 3A4 (CYP3A4) expression is often implicated in clinically relevant drug-drug interactions (DDI), as metabolism catalyzed by this enzyme is the dominant route of elimination for many drugs.
Fumiyoshi Yamashita   +7 more
doaj   +1 more source

Aflatoxin B1 Conversion by Black Soldier Fly (Hermetia illucens) Larval Enzyme Extracts

open access: yesToxins, 2019
The larvae of the black soldier fly (Hermetia illucens L., BSFL) have received increased industrial interest as a novel protein source for food and feed.
Nathan Meijer   +5 more
doaj   +1 more source

Improved expression of Catechol 1,2-dioxygenase gene from Burkholderia cepacia in Escherichia coli

open access: yesTạp chí Khoa học Đại học Huế: Khoa học Tự nhiên, 2020
Catechol 1,2-dioxygenase (CAT1) is a key enzyme for the ortho-cleavage pathway involved in the degradation of dibenzofuran, a dioxin derivative, which is a highly toxic environmental pollutant.
Van Thanh Dang   +5 more
doaj   +1 more source

Inhibition and induction of CYP enzymes in humans: an update

open access: yesArchives of Toxicology, 2020
The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies and toxic compounds in the environment.
J. Hakkola   +3 more
semanticscholar   +1 more source

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