Results 41 to 50 of about 653,394 (261)

Hematopoietic stem cell transplantation improves the high incidence of neutralizing allo-antibodies observed in Hurler’s syndrome after pharmacological enzyme replacement therapy

Haematologica, 2012
Background Mucopolysaccharidosis type I is caused by deficiency of α-L-iduronidase. Currently available treatment options include an allogeneic hematopoietic stem cell transplant and enzyme replacement therapy.
Muhammad Ameer Saif, Brian W. Bigger, Karen E Brookes, Jean Mercer, Karen L. Tylee, Heather J. Church, Denise K. Bonney, Simon Jones, J. Ed Wraith, Robert F. Wynn   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Regulation of Sialidase Biosynthesis by Control Mechanism Induction in Antarctic Strain Penicillium griseofulvum P29

Sci
In recent years, sialidases (neuraminidases) derived from non-clinical sources have attracted considerable interest due to their potential applications in the food and pharmaceutical industries.
Radoslav Abrashev, Ekaterina Krumova, Penka Petrova, Rumyana Eneva, Vladislava Dishliyska, Stephan Engibarov, Yana Gocheva, Galina Stoyancheva, Jeny Miteva-Staleva, Lyudmila Yovchevska, Boryana Spasova, Vera Kolyovska, Maria Angelova   +12 more
doaj   +1 more source

The Antioxidant System in the Respiratory Tract The Intracellular Antioxidant Protection in the Respiratory Tract (Part 1)

Zdorovʹe Rebenka, 2016
The literature review presents modern data on the intracellular antioxidant protection in the respiratory tract. The induction of the enzyme synthesis of antioxidant system is described.
A.Ye. Abaturov, A.P. Volosovets, T.P. Borysova   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

EVALUATION OF THE INDUCTION OF LIPOLYTIC ENZYMES FROM A Pseudomona aeruginosa ISOLATED FROM AFRICAN PALM FRUIT (Elaeis guineensis) EVALUACIÓN DE LA INDUCCIÓN DE ENZIMAS LIPOLÍTICAS A PARTIR DE UNA Pseudomona aeruginosa AISLADA DEL FRUTO DE PALMA AFRICANA (Elaeis guineensis)

Vitae, 2012
Background: Extracellular lipases are found in the culture broth when the fermentation is at the end of the exponential phase. Lipases can be induced easily since they are produced by the presence of oily sources or other materials as surfactants, fatty ...
Yomaira USCÁTEGUI, Carlos JIMÉNEZ-JUNCA, Camilo SUÁREZ, Erlide PRIETO-CORREA   +3 more
doaj  

Analysis of enzyme induction in bacteria [PDF]

Biochemical Journal, 1975
The theoretical relations between the induced initiation and accumulation of lac mRNA and its translation are derived, taking the kinetics of repressor–operator dissociation and enzyme maturation into account. These relations are used to evaluate observed data on lac induction and to estimate a number of parameters that characterize the transcription ...
R, Young, H, Bremer
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

EVALUATION OF THE INDUCTION OF LIPOLYTIC ENZYMES FROM A Pseudomona aeruginosa ISOLATED FROM AFRICAN PALM FRUIT (Elaeis guineensis)

Vitae, 2013
Background: Extracellular lipases are found in the culture broth when the fermentation is at the end of the exponential phase. Lipases can be induced easily since they are produced by the presence of oily sources or other materials as surfactants, fatty ...
Yomaira USCÁTEGUI M., Carlos A. JIMÉNEZ-JUNCA, Camilo SUÁREZ M., Erlide PRIETO-CORREA   +3 more
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source