Results 51 to 60 of about 680,545 (215)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hematopoietic stem cell transplantation improves the high incidence of neutralizing allo-antibodies observed in Hurler’s syndrome after pharmacological enzyme replacement therapy

Haematologica, 2012
Background Mucopolysaccharidosis type I is caused by deficiency of α-L-iduronidase. Currently available treatment options include an allogeneic hematopoietic stem cell transplant and enzyme replacement therapy.
Muhammad Ameer Saif, Brian W. Bigger, Karen E Brookes, Jean Mercer, Karen L. Tylee, Heather J. Church, Denise K. Bonney, Simon Jones, J. Ed Wraith, Robert F. Wynn   +9 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Regulation of Sialidase Biosynthesis by Control Mechanism Induction in Antarctic Strain Penicillium griseofulvum P29

Sci
In recent years, sialidases (neuraminidases) derived from non-clinical sources have attracted considerable interest due to their potential applications in the food and pharmaceutical industries.
Radoslav Abrashev, Ekaterina Krumova, Penka Petrova, Rumyana Eneva, Vladislava Dishliyska, Stephan Engibarov, Yana Gocheva, Galina Stoyancheva, Jeny Miteva-Staleva, Lyudmila Yovchevska, Boryana Spasova, Vera Kolyovska, Maria Angelova   +12 more
doaj   +1 more source

The Antioxidant System in the Respiratory Tract The Intracellular Antioxidant Protection in the Respiratory Tract (Part 1)

Zdorovʹe Rebenka, 2016
The literature review presents modern data on the intracellular antioxidant protection in the respiratory tract. The induction of the enzyme synthesis of antioxidant system is described.
A.Ye. Abaturov, A.P. Volosovets, T.P. Borysova   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

EVALUATION OF THE INDUCTION OF LIPOLYTIC ENZYMES FROM A Pseudomona aeruginosa ISOLATED FROM AFRICAN PALM FRUIT (Elaeis guineensis) EVALUACIÓN DE LA INDUCCIÓN DE ENZIMAS LIPOLÍTICAS A PARTIR DE UNA Pseudomona aeruginosa AISLADA DEL FRUTO DE PALMA AFRICANA (Elaeis guineensis)

Vitae, 2012
Background: Extracellular lipases are found in the culture broth when the fermentation is at the end of the exponential phase. Lipases can be induced easily since they are produced by the presence of oily sources or other materials as surfactants, fatty ...
Yomaira USCÁTEGUI, Carlos JIMÉNEZ-JUNCA, Camilo SUÁREZ, Erlide PRIETO-CORREA   +3 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

EVALUATION OF THE INDUCTION OF LIPOLYTIC ENZYMES FROM A Pseudomona aeruginosa ISOLATED FROM AFRICAN PALM FRUIT (Elaeis guineensis)

Vitae, 2013
Background: Extracellular lipases are found in the culture broth when the fermentation is at the end of the exponential phase. Lipases can be induced easily since they are produced by the presence of oily sources or other materials as surfactants, fatty ...
Yomaira USCÁTEGUI M., Carlos A. JIMÉNEZ-JUNCA, Camilo SUÁREZ M., Erlide PRIETO-CORREA   +3 more
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source