Results 101 to 110 of about 6,711,495 (336)

Covalently bound substrate at the regulatory site triggers allosteric enzyme activation [PDF]

, 2008
The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of ...
Steffen Kutter, König, Stephan, Kutter, Steffen, Manfred Weiss, Golbik, Ralph, Michael Spinka, Stephan König, Georg Wille, Ralph Golbik, Spinka, Michael, Weiss, Manfred S., Wille, Georg   +11 more
core  

Quantum chemical modeling of the inhibition mechanism of monoamine oxidase by oxazolidinone and analogous heterocyclic compounds

, 2014
Monoamine oxidase (MAO, EC 1.4.3.4) is responsible from the oxidation of a variety of amine neurotransmitters. MAO inhibitors are used for the treatment of depression or Parkinson's disease.
ERDEM, SAFİYE
core   +1 more source

Washingtonia filifera seed extracts inhibit the islet amyloid polypeptide fibrils formations and alpha-amylase and alpha-glucosidase activity

, 2021
Washingtonia filifera seeds have revealed to possess antioxidant properties, butyrylcholinesterase and xanthine oxidase inhibition activities. The literature has indicated a relationship between Alzheimer's disease (AD) and type-2 diabetes (T2D). Keeping
Era, Benedetta, Fais, Antonella, Westermark, Gunilla, Pintus, Francesca, Medda, Rosaria, Floris, Sonia, Kus, Piotr Marek, Medda, Rosaria,, Pintus, Francesca,, Kumar, Amit,, Era, Benedetta,, Piras, Alessandra, Kus, Piotr Marek,, Westermark, Gunilla,, Kumar, Amit, Fais, Antonella,, Piras, Alessandra,, Floris, Sonia,   +17 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Enzymolysis Modes Trigger Diversity in Inhibitor‐α‐Amylase Aggregating Behaviors and Activity Inhibition: A New Insight Into Enzyme Inhibition

Advanced Science
Inhibitors of α‐amylase have been developed to regulate postprandial blood glucose fluctuation. The enzyme inhibition arises from direct or indirect inhibitor‐enzyme interactions, depending on inhibitor structures.
Junwei Cao, Jifan Zhang, Ruibo Cao, Bin Zhang, Ming Miao, Xuebo Liu, Lijun Sun   +6 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor

, 2012
Cruzain is the major cysteine protease of Trypanosoma cruzi, the infectious agent responsible for Chagas disease, and cruzain inhibitors display considerable antitrypanosomal activity. In the present work we elucidated crystallographic data of fukugetin,
Nagem, Tanus Jorge, Izidoro, Mario Augusto [UNIFESP], Juliano, Maria Aparecida, Camps, Ihosvany, Tersariol, Ivarne Luis dos Santos [UNIFESP], Juliano, Maria Aparecida [UNIFESP], Pereira, Ivan de Oliveira, Assis, Diego Magno [UNIFESP], Santos, Jorge Alexandre Nogueira [UNIFESP], Barros, Nilana Meza Tenório de, Tersariol, Ivarne Luis dos Santos, Barros, Nilana Meza Tenório de [UNIFESP], Santos, Marcelo Henrique dos, Doriguetto, Antonio Carlos, Izidoro, Mario Augusto, Assis, Diego Magno, Ellena, Javier, Gontijo, Vanessa Silva, Santos, Jorge Alexandre Nogueira   +18 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Anti-inflammatory activities of some bee products by inhibition of bovine testes hyaluronidase

, 2016
Background: Apitherapeutic products contain many valuable bioactive compounds which are responsible for biologically active features such as anti-oxidant, anti-viral, anti-microbial and anti-inflammatory properties.
Kolayli S., Cakir H.E., Sahin H., Can Z., Yildiz O.   +4 more
core   +1 more source