Results 151 to 160 of about 4,881,376 (355)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A Novel Bioactive Emulgel with <i>Phlomis kurdica</i>: Antioxidant Potential, Enzyme Inhibition and Permeation Kinetics. [PDF]

Gels
Şentürk TB, Barak TH, Çağlar EŞ, Saldamlı E, Özdemir Nath E, Özdemir ZÖ.   +5 more
europepmc   +1 more source

Methotrexate analogs. 19. Replacement of the glutamate side-chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity

, 1984
A. Rosowsky, Ronald A. Forsch, James H. Freisheim, Richard G. Moran, Michael M. Wick   +4 more
openalex   +1 more source

Isothermal Titration Calorimetry Enables Rapid Characterization of Enzyme Kinetics and Inhibition for the Human Soluble Epoxide Hydrolase [PDF]

, 2019
Giancarlo Abis, Raúl Pacheco‐Gómez, Tam T. T. Bui, Maria R. Conte   +3 more
openalex   +1 more source

Digestive enzyme inhibition activity of the phenolic substances in selected fruits, vegetables and tea as compared to black legumes

, 2017
Yuqing Tan, Sam K C Chang
semanticscholar   +1 more source

Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin)

Human and Experimental Toxicology, 2016
Gokhan Zengin, N. Degirmenci, L. Alpsoy, A. Aktumsek   +3 more
semanticscholar   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms. [PDF]

FEBS Open Bio
Chagas RS, Marana SR.
europepmc   +1 more source

EVALUATION OF ANTIBACTERIAL, ANTIFUNGAL, ENZYME INHIBITION AND HEMOLYTIC ACTIVITIES OF CARYOPTERIS ODORATA FRACTIONS

, 2014
Muhammad Athar Abbasi, Azizur Rehman, Viqar Uddin Ahmad, Tauheeda Riaz, Farah Khlaid   +4 more
openalex   +1 more source

Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro [PDF]

, 2016
Meghan F. Hogan, Daniel T. Meier, Sakeneh Zraika, Andrew T. Templin, Mahnaz Mellati, Rebecca L. Hull, Malcolm A. Leissring, Steven E. Kahn   +7 more
openalex   +1 more source