Results 231 to 240 of about 4,881,376 (355)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Supercritical CO₂ extraction of hemp seeds: A multivariate perspective on the influence of processing parameters on oil composition, antioxidant activity, and enzyme inhibition. [PDF]

Food Chem X
Vishwasrao P, Zengin G, Sinan KI, Minceva M, Luca SV.   +4 more
europepmc   +1 more source

Chemical Profiling and Biological Activities of Methanol Extracts and Essential Oils from Ferulago platycarpa Boiss. & Balansa (Endemic): Enzyme Inhibition, Antioxidant, and Antimicrobial Properties

İmdat Aygül, Mehmet Öz, Muhammed Said Fidan, Cemalettin Baltacı, Osman Akmeşe, Abdurrahman Sefalı   +5 more
openalex   +1 more source

In Vitro Inhibition of Cardiometabolic Health-Related Enzymes by Monofloral Stingless Bee Honey [PDF]

Fuen Ann Tan, Ai Ling Ho, Fook Yee Chye
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Oligoethylene Phosphoramidate-Based Kinase Inhibitor Prodrugs - Solubility, Enzyme Inhibition, and Hydrolysis. [PDF]

Chemistry
Spiewok S, Schaefer M, Lamla M, Jaritz Y, Kuehne AJC.   +4 more
europepmc   +1 more source

Cytotoxicity and enzyme inhibition studies of polyoxometalates and their chitosan nanoassemblies

, 2014
Hamid Saeed Shah, Rami Al‐Oweini, Ali Haider, Ulrich Kortz, Jamshed Iqbal   +4 more
openalex   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Isolation and characterization of bioactive constituents from <i>Withania coagulans</i> Dunal with antioxidant and multifunctional enzyme inhibition potential, supported by docking, MD, and DFT studies. [PDF]

RSC Adv
Bibi H, Maher S, Khan N, Khan S, Chohan TA, Saleem H, Abdellattif MH, Khan A, Al-Harrasi A.   +8 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source