Results 211 to 220 of about 971,704 (261)
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Enzyme induction and inhibition
Pharmacology & Therapeutics, 1990The rate and extent of drug metabolism significantly influences drug effect. Enzyme induction by increasing the metabolism of drugs may result in important drug interactions. Other implications of enzyme induction include alterations in the metabolism of endogenous substrates, vitamins and activity of extrahepatic enzyme systems. Similarly a wide range
M, Barry, J, Feely
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Current Bioactive Compounds, 2007
One aspect of the importance of enzymes in biology can be appreciated by considering the attention that continues to be focused on the inhibition of enzymatic activity. Historically, inhibitors played important roles in the elucidation of metabolic pathways.
Perry A. Frey, Adrian D. Hegeman
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One aspect of the importance of enzymes in biology can be appreciated by considering the attention that continues to be focused on the inhibition of enzymatic activity. Historically, inhibitors played important roles in the elucidation of metabolic pathways.
Perry A. Frey, Adrian D. Hegeman
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2023
This chapter discusses enzyme inhibition. A major aspect of the regulation of enzyme activity and therefore of the balance of reaction rates in organisms is the possibility that a compound can inhibit the enzyme's action. The modulation of the activity of enzymes with effector molecules is essential for the coordination of the huge number of reactions ...
Pranati Das +4 more
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This chapter discusses enzyme inhibition. A major aspect of the regulation of enzyme activity and therefore of the balance of reaction rates in organisms is the possibility that a compound can inhibit the enzyme's action. The modulation of the activity of enzymes with effector molecules is essential for the coordination of the huge number of reactions ...
Pranati Das +4 more
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ENZYME INHIBITION BY ANTIBODIES
Acta Endocrinologica, 1975ABSTRACT The interest in the inhibition of enzymes by their specific antibodies stems mainly from the fact that these systems can serve as suitable models in the study of neutralization of biologically active molecules in general. The interaction of enzymes with their specific antibodies generally leads to a reduction in their enzymatic ...
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Inhibition of enzymes by lipoproteins
Biochimica et Biophysica Acta, 1956Abstract 1. 1. Experiments designed to test the specificity of lipoproteins as inhibitors of glucose utilisation are presented. 2. 2. It has been shown that the difference between normal and diabetic plasma in regard to content of this material is largely quantitative. 3. 3.
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Diagnosis of enzyme inhibition based on the degree of inhibition
Biochimica et Biophysica Acta (BBA) - General Subjects, 2003In this work, a method for the diagnosis of kinetic inhibition, based on the dependence of the degree of inhibition (epsilon(i)) on the inhibitor concentration [I] and on the substrate concentration [S], is presented. Because the degree of inhibition is a ratio between rates, kinetic data are normalized by the introduction of an internal control-the ...
Antunes, Fernando +4 more
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Clinical Implications of Enzyme Induction and Enzyme Inhibition
Clinical Pharmacokinetics, 1981The pharmacological effect of a drug is partly dependent upon its concentration at its site of action, which in turn is partly dependent upon its rate of elimination. The rate of elimination of many lipophilic drugs is governed by the activity of the hepatic microsomal mixed-function oxidases.
B K, Park, A M, Breckenridge
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Angiotensin converting enzyme inhibition and renin inhibition
Journal of Hypertension, 1989Over a period of several years, methods of measuring circulating angiotensin II have been progressively improved and it has now become possible to measure circulating angiotensin II with a high degree of accuracy. The main ingredients in this new methodology are bonded-phase silica for quantitative angiotensin extraction from biological fluids and ...
Nussberger J, Waeber B, Brunner HR
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Enzyme inhibition by tetraphenylboron
Biochimica et Biophysica Acta (BBA) - Enzymology, 1969J B, Stanbury, J V, Wicken
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Chemical Aspects of Enzyme Inhibition
Science, 1957The use of chemical reagents as enzyme inhibitors has yielded information concerning the mechanism of inhibition and the role in catalysis played by active groups on the protein apoenzyme, the coenzyme, or the metal component. Inhibition analysis has also furnished valuable clues concerning the architecture, chemical properties, and ...
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