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Enzyme inactivation and inhibition by Gossypol
Molecular and Cellular Biochemistry, 1982Three lactate dehydrogenase isozymes and malate dehydrogenase purified from mouse tissues were inactivated with time by low concentration of gossypol. The degree of enzyme inactivation is both gossypol- and enzyme-concentration-dependent. Under the same experimental conditions, lactate dehydrogenase-X and lactate dehydrogenase-5 were inactivated faster
C Y, Lee +3 more
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Fungal Invasion Enzymes and Their Inhibition
1997The first lines of defense of a plant against phytopathogenic fungi are the external cuticle and the polysaccharide-rich cell wall (Fig. 1). The vast majority of fungi need to breach these barriers to gain access to the plant tissue, and, once inside the tissue, to degrade the cell wall components in order to sustain their growth and to complete the ...
DE LORENZO, Giulia +3 more
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Aromatase: The Enzyme and Its Inhibition
Anti-Cancer Agents in Medicinal Chemistry, 2009The genetic control, mechanism of action and inhibition of aromatase for potential therapeutic benefits in the arena of hormone dependent illness continues to be of considerable interest. The work presented here concentrates on recent advances in the mechanistic aspects of the aromatase enzyme and the nature of the chemical entities that lead to ...
Banting, Lee, Ahmed, S.
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Chemical Aspects of Enzyme Inhibition
Science, 1957The use of chemical reagents as enzyme inhibitors has yielded information concerning the mechanism of inhibition and the role in catalysis played by active groups on the protein apoenzyme, the coenzyme, or the metal component. Inhibition analysis has also furnished valuable clues concerning the architecture, chemical properties, and ...
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Enzyme inhibition by acetylenic compounds
Biochemical and Biophysical Research Communications, 1970Abstract Soybean lipoxidase and prostaglandin synthetase from sheep seminal vesicles are subject to powerful inhibition by 5,8,11,14-eicosatetraynoic acid, apparently by a slow but irreversible attack on the enzymes. It is postulated that inhibition may result from conversion of the acetylenic compound to a reactive allene by the enzymes studied, as ...
D T, Downing, D G, Ahern, M, Bachta
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An unusual type of enzyme inhibition
Biochimica et Biophysica Acta (BBA) - Enzymology, 1973The inhibition of papain by benzoylamido acetonitrile with benzoylglycine methyl-ester as substrate exhibits unusual kinetics. In the double reciprocal plot the lines of various inhibitor concentrations intersect in the first quadrant. It is tenatively explained by association between substrate and inhibitor.
Sluyterman, L.A.A.E., Wijdenes, J.
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Enzyme inhibition by tetraphenylboron
Biochimica et Biophysica Acta (BBA) - Enzymology, 1969J B, Stanbury, J V, Wicken
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