Results 1 to 10 of about 689,358 (215)

Nanozymes as Enzyme Inhibitors

International Journal of Nanomedicine, 2021
Yaling Huang,1 Jian Jiang,1 Yanqiu Wang,1 Jie Chen,1 Juqun Xi1,2 1Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of China; 2Jiangsu Key ...
Huang Y, Jiang J, Wang Y, Chen J, Xi J
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Enzyme Inhibitors as Multifaceted Tools in Medicine and Agriculture [PDF]

Molecules
Enzymes are molecules that play a crucial role in maintaining homeostasis and balance in all living organisms by catalyzing metabolic and cellular processes.
Sonia Del Prete, Mario Pagano
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Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors

Exploration of Targeted Anti-tumor Therapy, 2023
Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma.
Markus Schweipert, Anuja Amurthavasan, Franz-Josef Meyer-Almes   +2 more
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Inhibition of antioxidant enzyme activities enhances carotenogenesis in microalga Dactylococcus dissociatus MT1

Frontiers in Bioengineering and Biotechnology, 2022
Microalgal biotechnology has become a promising field of research for the production of valuable, sustainable and environmentally friendly byproducts, especially for carotenoids. Bulk accumulation of secondary carotenoids in microalgae are mostly induced
Nour Elaimane Bouzidi, Samir Borhane Grama , Aboubakeur Essedik Khelef , Duanpeng Yang , Jian Li    +4 more
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Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A series of 20 newly designed (E)-1-(4-sulphamoylphenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones was synthesised and assessed as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors towards four human isoforms of pharmaceutical interest, that is, hCA I ...
Farhat Ramzan, Syed Ayaz Nabi, Mehak Saba Lone, Alessandro Bonardi, Aabid Hamid, Sameena Bano, Kalicharan Sharma, Syed Shafi, Mohammed Samim, Kalim Javed, Claudiu T. Supuran   +10 more
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Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication

Viruses, 2023
Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs.
Abhishek Asthana, Angela Corona, Woo-Jin Shin, Mi-Jeong Kwak, Christina Gaughan, Enzo Tramontano, Jae U. Jung, Rainer Schobert, Babal Kant Jha, Robert H. Silverman, Bernhard Biersack   +10 more
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Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families

Marine Drugs, 2023
Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso, Fabiola Almeida García, Mario Ernesto Valdés Tresanco, Yarini Arrebola Sánchez, Daniel Ojeda del Sol, Belinda Sánchez Ramírez, Isabelle Florent, Marjorie Schmitt, Francesc Xavier Avilés   +8 more
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Mechanistic Aspects of Apiaceae Family Spices in Ameliorating Alzheimer’s Disease

Antioxidants, 2021
Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases worldwide. In an effort to search for new strategies for treating AD, natural products have become candidates of choice.
Niti Sharma, Mario A. Tan, Seong Soo A. An   +2 more
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Phytochemical Composition, Antioxidant, and Enzyme Inhibition Activities of Methanolic Extracts of Two Endemic Onosma Species

Plants, 2021
Onosma species have been used as a dye for hundreds of years due to their dark red pigments. These species have also been used by mankind in the treatment of various diseases since ancient times.
Kandasamy Saravanakumar, Cengiz Sarikurkcu, Saliha Seyma Sahinler, Rabia Busra Sarikurkcu, Myeong-Hyeon Wang   +4 more
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Impact of genetic variations on pharmacokinetic and pharmacodynamic properties of medicines and the future of drug therapy

Zanco Journal of Medical Sciences, 2020
Genetic variations between individuals usually leads to differences in the drug response as it could affect both pharmacokinetic and pharmacodynamic processes. An example of mutation of genes that affect drug targets (pharmacodynamic) is VKORC1 gene that
Rojgar Hamed Ali
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