Results 1 to 10 of about 1,166,240 (350)

Phytochemicals and Enzyme Inhibitory Capacities of the Methanolic Extracts from the Italian Apple Cultivar Mela Rosa dei Monti Sibillini

Pharmaceuticals, 2020
The phytochemical profile of the methanolic extracts (pulp and peel) obtained from two dehydration methods (drying and freeze-lyophilization) of the traditional Italian apple Mela Rosa dei Monti Sibillini, as well as their inhibitory properties against ...
Víctor López, Francisco Les, Serena Mevi, Joice Guileine Nkuimi Wandjou, Guillermo Cásedas, Giovanni Caprioli, Filippo Maggi   +6 more
doaj   +1 more source

Inhibition of antioxidant enzyme activities enhances carotenogenesis in microalga Dactylococcus dissociatus MT1

Frontiers in Bioengineering and Biotechnology, 2022
Microalgal biotechnology has become a promising field of research for the production of valuable, sustainable and environmentally friendly byproducts, especially for carotenoids. Bulk accumulation of secondary carotenoids in microalgae are mostly induced
Nour Elaimane Bouzidi, Samir Borhane Grama , Aboubakeur Essedik Khelef , Duanpeng Yang , Jian Li    +4 more
doaj   +1 more source

Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors

Exploration of Targeted Anti-tumor Therapy, 2023
Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma.
Markus Schweipert, Anuja Amurthavasan, Franz-Josef Meyer-Almes   +2 more
doaj   +1 more source

Selective inhibition of carotenoid cleavage dioxygenases : phenotypic effects on shoot branching [PDF]

, 2009
Members of the carotenoid cleavage dioxygenase family catalyse the oxidative cleavage of carotenoids at various chain positions, leading to the formation of a wide range of apocarotenoid signalling molecules.
Auldridge, Zeevaart, Schwartz, von Lintig, Wyss, Kiefer, Hu, Dudareva, Bouvier, Juttner, Kloer, Marasco, Eisner, Fester, Matusova, Akiyama, Gomez-Roldan, Umehara, Ward, Sorefan, Booker, Schwartz, Alder, Booker, Bennett, Cunningham, Schwartz, Stockwell, Armstrong, Kaschani, Han, Kitahata, Suzuki, Han, Bergeron, Kawase, Schmidt, Cunningham, Wilson, Chatfield, Taylor, Borowski, Kontogiorgis, Simkin, Burbidge, Vogel, Paik, Scherzinger, Bouvier, Quinlan, Walter, Yeh, Alija   +52 more
core   +1 more source

Immobilized enzyme reactors in HPLC and its application in inhibitor screening: A review

Journal of Pharmaceutical Analysis, 2012
This paper sets out to summarize the literatures based on immobilized enzyme bio-chromatography and its application in inhibitors screening in the last decade.
Si-Meng Fang, Hai-Na Wang, Zhong-Xi Zhao, Wei-Hong Wang   +3 more
doaj   +1 more source

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. [PDF]

, 2010
Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma.
Alex Berndt, Benjamin T Houseman, Christian Rommel, Daniel D Le, Fabrice Gorrec, Jeffrey P Shaw, Joseph I Pacold, Kevan M Shokat, Matthias K Schwarz, Olusegun Williams, Pascale Gaillard, Pingda Ren, Roger L Williams, Simon Miller, Thomas Rückle, Wai-Ching Hon, Yi Liu   +16 more
core   +2 more sources

A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

EMBO Molecular Medicine, 2012
Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann, Nora Overlack, Fabian Möller, Valery Belakhov, Michiel van Wyk, Timor Baasov, Uwe Wolfrum, Kerstin Nagel‐Wolfrum   +7 more
doaj   +1 more source

Metalloporphyrins inactivate caspase-3 and -8 [PDF]

, 2005
Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B., Brandt, Birte, Höltje, Hans-Dieter, Höltje, Monika, Kiemer, Alexandra K., Seyfried, Stefan, Tiegs, Gisa, Vollmar, Angelika M., Zahler, Stefan   +8 more
core   +1 more source

Harnessing the Bioactive Potential of Limonium spathulatum (Desf.) Kuntze: Insights into Enzyme Inhibition and Phytochemical Profile

Plants, 2023
This study assessed the halophyte species Limonium spathulatum (Desf.) as a possible source of natural ingredients with the capacity to inhibit enzymes related to relevant human health disorders and food browning.
Seria Youssef, Luisa Custódio, Maria João Rodrigues, Catarina G. Pereira, Ricardo C. Calhelha, József Jekő, Zoltán Cziáky, Karim Ben Hamed   +7 more
doaj   +1 more source

Synthetic (p)ppGpp analogue is an inhibitor of stringent response in mycobacteria [PDF]

, 2017
Bacteria elicit an adaptive response against hostile conditions such as starvation and other kinds of stresses. Their ability to survive such conditions depends, in part, on stringent response pathways.
Bhardwaj, Neerupma, Chatterji, Dipankar, Flentie, Kelly, Jayaraman, Narayanaswamy, Maiti, Krishnagopal, Stallings, Christina L, Syal, Kirtimaan   +6 more
core   +2 more sources