Results 11 to 20 of about 689,457 (314)
Enzyme Inhibitors from Gorgonians and Soft Corals
Marine Drugs, 2023 For decades, gorgonians and soft corals have been considered promising sources of bioactive compounds, attracting the interest of scientists from different fields. As the most abundant bioactive compounds within these organisms, terpenoids, steroids, and
Andrea Córdova-Isaza +3 more
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Flavivirus enzymes and their inhibitors
, 2021 Flaviviruses such as dengue, Japanese encephalitis, West Nile, Yellow Fever and Zika virus, cause viral hemorrhagic fever and encephalitis in humans. However, antiviral therapeutics to treat or prevent flavivirus infections are not yet available. Thus, there is pressing need to develop therapeutics and vaccines that target flavivirus infections.
Marc C. Morais +2 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Human carbonic anhydrase IX (CA IX), a protein specifically expressed on the surface of solid tumour cells, represents a validated target both for anticancer therapy and diagnostics.
Michael Kugler +10 more
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Immobilized enzyme reactors in HPLC and its application in inhibitor screening: A review
Journal of Pharmaceutical Analysis, 2012 This paper sets out to summarize the literatures based on immobilized enzyme bio-chromatography and its application in inhibitors screening in the last decade.
Si-Meng Fang +3 more
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In Vitro Enzymatic Studies Reveal pH and Temperature Sensitive Properties of the CLIC Proteins
Biomolecules, 2023 Chloride intracellular ion channel (CLIC) proteins exist as both soluble and integral membrane proteins, with CLIC1 capable of shifting between two distinct structural conformations. New evidence has emerged indicating that members of the CLIC family act
Amani Alghalayini +6 more
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EMBO Molecular Medicine, 2012 Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann +7 more
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Molecules, 2023 We previously reported dipeptidomimetic compounds as inhibitors of neuronal and/or inducible NO synthases (n/iNOS) with significant selectivity against endothelial NOS (eNOS).
Elodie Mauchauffée +10 more
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Antibiotics, 2023 Alginates play an important role in the resistance of mucoid strains of Pseudomonas aeruginosa to antibiotics, as well as their persistence by escaping the immune defense system.
Christian Hulen
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International Research Journal Of Pharmacy, 2021 Enzymes play very important role in living organism as biocatalyst. They play vital role like secretion, metabolism, digestion, DNA functions, reproduction, conversation of molecules and many other functions of body. By inhibiting specific enzymes, we can cure numerous pathological conditions in humans like inhibiting HMG CoA reductase, we can decrease
Vipul Vaghela +2 more
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Angiotensin-Converting Enzyme Inhibitors [PDF]
The Journal of Clinical Hypertension, 2011 KEY POINTS AND RECOMMENDATIONS: • In addition to hypertension, angiotensin-converting enzyme inhibitors are indicated for treatment of patients at high risk for coronary artery disease, after myocardial infarction, with dilated cardiomypathy, or with chronic kidney disease.
Joseph L. Izzo, Matthew R. Weir
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