Results 11 to 20 of about 5,024,684 (342)

Enzyme Inhibitors and Activators [PDF]

, 2017
Enzymes are very effective biological catalysts that accelerate almost all metabolic reactions in living organisms. Enzyme inhibitors and activators that modulate the velocity of enzymatic reactions play an important role in the regulation of metabolism.
Karaman, M. Rustu, GÜNEŞ, Adem, Mokhtari, Negar Ebrahim Pour, NİKEREL, Emrah, TUFENKCI, M. SEFIK, KITİR, Nurgül, KAYA, Kerem, TURAN, Metin, CIMRIN, KERIM MESUT   +8 more
semanticscholar   +11 more sources

Small molecule angiotensin converting enzyme inhibitors: A medicinal chemistry perspective

Frontiers in Pharmacology, 2022
Angiotensin-converting enzyme (ACE), a zinc metalloprotein, is a central component of the renin–angiotensin system (RAS). It degrades bradykinin and other vasoactive peptides.
Wenyue Zheng, Erkang Tian, Zhen Liu, Changhan Zhou, Pei Yang, Keyue Tian, W. Liao, Juan Li, Changyu Ren   +8 more
semanticscholar   +1 more source

Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in ...
Peng Zhang, Lihua Zhu, Jingjing Cai, Fang Lei, Juan-Juan Qin, Jing Xie, Ye Liu, Yan-Ci Zhao, Xuewei Huang, Lijin Lin, Meng Xia, Ming-Ming Chen, Xu Cheng, Xiao Zhang, D. Guo, Yuanyuan Peng, Yan‐Xiao Ji, J. Chen, Zhi‐Gang She, Yibin Wang, Qingbo Xu, Renfu Tan, Hai-tao Wang, Jun Lin, Pengcheng Luo, Shouzhi Fu, Hongbing Cai, P. Ye, B. Xiao, W. Mao, Liming Liu, You-qin Yan, Mingyu Liu, Manhua Chen, Xiao-Jing Zhang, Xinghuan Wang, R. Touyz, J. Xia, Bing-Hong Zhang, Xiaodong Huang, Yufeng Yuan, L. Rohit, Peter P. Liu, Hongliang Li   +43 more
semanticscholar   +1 more source

Hypothesis: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19

Journal of Travel Medicine, 2020
Highlight Intravenous infusions of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in experimental animals increase the numbers of angiotensin-converting enzyme 2 (ACE2) receptors in the cardiopulmonary ...
J. Diaz
semanticscholar   +1 more source

Angiotensin‐converting enzyme inhibitors and angiotensin II receptor blockers are not associated with severe COVID‐19 infection in a multi‐site UK acute hospital trust

European Journal of Heart Failure, 2020
The SARS‐CoV‐2 virus binds to the angiotensin‐converting enzyme 2 (ACE2) receptor for cell entry. It has been suggested that angiotensin‐converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB), which are commonly used in patients ...
D. Bean, Zeljko Kraljevic, Thomas Searle, R. Bendayan, O'Gallagher Kevin, A. Pickles, A. Folarin, Lukasz Roguski, Kawsar Noor, Anthony Shek, R. Zakeri, A. Shah, J. Teo, R. Dobson   +13 more
semanticscholar   +1 more source

Phytochemical Composition, Antioxidant, and Enzyme Inhibition Activities of Methanolic Extracts of Two Endemic Onosma Species

Plants, 2021
Onosma species have been used as a dye for hundreds of years due to their dark red pigments. These species have also been used by mankind in the treatment of various diseases since ancient times.
Kandasamy Saravanakumar, Cengiz Sarikurkcu, Saliha Seyma Sahinler, Rabia Busra Sarikurkcu, Myeong-Hyeon Wang   +4 more
doaj   +1 more source

Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A series of 20 newly designed (E)-1-(4-sulphamoylphenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones was synthesised and assessed as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors towards four human isoforms of pharmaceutical interest, that is, hCA I ...
Farhat Ramzan, Syed Ayaz Nabi, Mehak Saba Lone, Alessandro Bonardi, Aabid Hamid, Sameena Bano, Kalicharan Sharma, Syed Shafi, Mohammed Samim, Kalim Javed, Claudiu T. Supuran   +10 more
doaj   +1 more source

A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

EMBO Molecular Medicine, 2012
Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann, Nora Overlack, Fabian Möller, Valery Belakhov, Michiel van Wyk, Timor Baasov, Uwe Wolfrum, Kerstin Nagel‐Wolfrum   +7 more
doaj   +1 more source

The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Human carbonic anhydrase IX (CA IX), a protein specifically expressed on the surface of solid tumour cells, represents a validated target both for anticancer therapy and diagnostics.
Michael Kugler, Josef Holub, Jiří Brynda, Klára Pospíšilová, Suzan El Anwar, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, Milan Fábry, Bohumír Grüner, Pavlína Řezáčová   +10 more
doaj   +1 more source

Natural Inhibitors of the Aromatase Enzyme

Molecules, 2000
The results of three years of search for natural aromatase inhibitors will be presented.
Roberto R. Gil
doaj   +1 more source