Results 11 to 20 of about 5,417,177 (410)

Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
New C-glycosides and α,β-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated.
Leonardo E. Riafrecha, Macarena S. Le Pors, Martín J. Lavecchia, Silvia Bua, Claudiu T. Supuran, Pedro A. Colinas   +5 more
doaj   +1 more source

Hypothesis: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19

Journal of Travel Medicine, 2020
Highlight Intravenous infusions of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in experimental animals increase the numbers of angiotensin-converting enzyme 2 (ACE2) receptors in the cardiopulmonary ...
J. Diaz
semanticscholar   +1 more source

Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening

Molecules, 2023
A biomimetic mineralization method was used in the facile and rapid preparation of nanoflowers for immobilizing alcohol dehydrogenase (ADH). The method mainly uses ADH as an organic component and zinc phosphate as an inorganic component to prepare flower-
Mao-Ling Luo, Hua Chen, Guo-Ying Chen, Shengpeng Wang, Yitao Wang, Feng-Qing Yang   +5 more
doaj   +1 more source

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

Antioxidants, 2021
Seseli L. is one of the largest genera of the Apiaceae family widely known for their traditional uses as herbal remedies. In the present study, the methanolic and water extracts of two Seseli species, S. gummiferum and S.
Gokhan Zengin, Dejan Stojković, Mohamad Fawzi Mahomoodally, Bibi Sharmeen Jugreet, Mehmet Yavuz Paksoy, Marija Ivanov, Uroš Gašić, Monica Gallo, Domenico Montesano   +8 more
doaj   +1 more source

The Fellowship of Privileged Scaffolds—One Structure to Inhibit Them All

Pharmaceuticals, 2021
Over the past few years, the application of privileged structure has emerged as a powerful approach to the discovery of new biologically active molecules.
Marcin Skoreński, Marcin Sieńczyk
doaj   +1 more source

Angiotensin‐converting enzyme inhibitors and angiotensin II receptor blockers are not associated with severe COVID‐19 infection in a multi‐site UK acute hospital trust

European Journal of Heart Failure, 2020
The SARS‐CoV‐2 virus binds to the angiotensin‐converting enzyme 2 (ACE2) receptor for cell entry. It has been suggested that angiotensin‐converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB), which are commonly used in patients ...
D. Bean, Z. Kraljevic, Thomas Searle, R. Bendayan, O'Gallagher Kevin, A. Pickles, A. Folarin, Lukasz Roguski, Kawsar Noor, Anthony Shek, R. Zakeri, A. Shah, J. Teo, R. Dobson   +13 more
semanticscholar   +1 more source

In Vitro Enzymatic Studies Reveal pH and Temperature Sensitive Properties of the CLIC Proteins

Biomolecules, 2023
Chloride intracellular ion channel (CLIC) proteins exist as both soluble and integral membrane proteins, with CLIC1 capable of shifting between two distinct structural conformations. New evidence has emerged indicating that members of the CLIC family act
Amani Alghalayini, Khondker Rufaka Hossain, Saba Moghaddasi, Daniel R. Turkewitz, Claudia D’Amario, Michael Wallach, Stella M. Valenzuela   +6 more
doaj   +1 more source

Harnessing the Bioactive Potential of Limonium spathulatum (Desf.) Kuntze: Insights into Enzyme Inhibition and Phytochemical Profile

Plants, 2023
This study assessed the halophyte species Limonium spathulatum (Desf.) as a possible source of natural ingredients with the capacity to inhibit enzymes related to relevant human health disorders and food browning.
Seria Youssef, Luisa Custódio, Maria João Rodrigues, Catarina G. Pereira, Ricardo C. Calhelha, József Jekő, Zoltán Cziáky, Karim Ben Hamed   +7 more
doaj   +1 more source

Natural Products from Medicinal Plants with Anti-Human Coronavirus Activities

Molecules, 2021
Since the emergence of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) first reported in Wuhan, China in December 2019, COVID-19 has spread to all the continents at an unprecedented pace.
Salar Hafez Ghoran, Mohamed El-Shazly, Nazim Sekeroglu, Anake Kijjoa   +3 more
doaj   +1 more source

Selective inhibition of carotenoid cleavage dioxygenases : phenotypic effects on shoot branching [PDF]

, 2009
Members of the carotenoid cleavage dioxygenase family catalyse the oxidative cleavage of carotenoids at various chain positions, leading to the formation of a wide range of apocarotenoid signalling molecules.
Akiyama, Alder, Alija, Armstrong, Auldridge, Bennett, Bergeron, Booker, Booker, Borowski, Bouvier, Bouvier, Burbidge, Chatfield, Cunningham, Cunningham, Dudareva, Eisner, Fester, Gomez-Roldan, Han, Han, Hu, Juttner, Kaschani, Kawase, Kiefer, Kitahata, Kloer, Kontogiorgis, Marasco, Matusova, Paik, Quinlan, Scherzinger, Schmidt, Schwartz, Schwartz, Schwartz, Simkin, Sorefan, Stockwell, Suzuki, Taylor, Umehara, Vogel, von Lintig, Walter, Ward, Wilson, Wyss, Yeh, Zeevaart   +52 more
core   +2 more sources