Results 231 to 240 of about 5,633,974 (393)

Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer

, 2019
Nathalia Sperotto, Candida Deves Roth, Valnês S. Rodrigues-Junior, Christiano Ev Neves, Fávero Reisdorfer Paula, Adílio da Silva Dadda, Pedro Bergo, Talita Freitas de Freitas, Fernanda Souza Macchi, Sidnei Moura, Ana Paula Duarte de Souza, Maria M. Campos, Cristiano Valim Bizarro, Diógenes Santiago Santos, Luiz Augusto Basso, Pablo Machado   +15 more
openalex   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and the Risk of Acute Pancreatitis: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Alves C, Costa B, Penedones A, Mendes D, Batel Marques F.   +4 more
europepmc   +1 more source

Discontinuation of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Chronic Kidney Disease

, 2019
Yao Qiao, Jung‐Im Shin, Yingying Sang, Lesley A. Inker, Alex Secora, Shengyuan Luo, Josef Coresh, G. Caleb Alexander, John W. Jackson, Alex R. Chang, Morgan E. Grams   +10 more
openalex   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Synthesis, Biological Evaluation, and In Silico Characterization of Novel Imidazothiadiazole-Chalcone Hybrids as Multi-Target Enzyme Inhibitors. [PDF]

Pharmaceuticals (Basel)
Alici H, Topuz S, Demir K, Taslimi P, Tahtaci H.   +4 more
europepmc   +1 more source

The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors [PDF]

, 2019
Mahnoush Bahjat, Guus de Wilde, Tijmen van Dam, Chiel Maas, Timon A. Bloedjes, Richard J. Bende, Carel J.M. van Noesel, Dieuwertje M. Luijks, Eric Eldering, Marie José Kersten, Jeroen E. J. Guikema   +10 more
openalex   +1 more source

Therapy of endocrine disease: steroidogenesis enzyme inhibitors in Cushing's syndrome.

European Journal of Endocrinology, 2015
Eleni Daniel, J. Newell-Price
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Exploring the Potential of Pyridine Carboxylic Acid Isomers to Discover New Enzyme Inhibitors. [PDF]

Drug Des Devel Ther
Yaqoob S, Khan FA, Tanveer N, Ali S, Hameed A, El-Seedi H, Jiang ZH, Wang Y.   +7 more
europepmc   +1 more source