Results 21 to 30 of about 689,457 (314)
Pharmaceuticals, 2020 The phytochemical profile of the methanolic extracts (pulp and peel) obtained from two dehydration methods (drying and freeze-lyophilization) of the traditional Italian apple Mela Rosa dei Monti Sibillini, as well as their inhibitory properties against ...
Víctor López +6 more
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Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1
Molecules, 2015 The human 8-oxoguanine DNA glycosylase OGG1 is involved in base excision repair (BER), one of several DNA repair mechanisms that may counteract the effects of chemo- and radiation therapy for the treatment of cancer. We envisage that potent inhibitors of
Tushar R. Mahajan +4 more
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Plants, 2023 This study assessed the halophyte species Limonium spathulatum (Desf.) as a possible source of natural ingredients with the capacity to inhibit enzymes related to relevant human health disorders and food browning.
Seria Youssef +7 more
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INHIBITORS OF THE TRANSCRIBING ENZYMES [PDF]
Pure and Applied Chemistry, 1973 Abstract
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Exploring N-acyl-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-enes as 11β-HSD1 Inhibitors
Molecules, 2018 We recently found that a cyclohexanecarboxamide derived from 4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene displayed low nanomolar inhibition of 11β-HSD1.
Rosana Leiva +4 more
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Brazilian Archives of Biology and Technology, 2022 The genus Eucalyptus present high content of essential oil (EO). This study evaluated the pharmacological properties of Eucalyptus grandis (EG) and Eucalyptus microcorys (EM) EOs. The major component in both EOs was 1,8-Cineole.
Mariana Araújo Esposito +4 more
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The Fellowship of Privileged Scaffolds—One Structure to Inhibit Them All
Pharmaceuticals, 2021 Over the past few years, the application of privileged structure has emerged as a powerful approach to the discovery of new biologically active molecules.
Marcin Skoreński, Marcin Sieńczyk
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Natural Products from Medicinal Plants with Anti-Human Coronavirus Activities
Molecules, 2021 Since the emergence of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) first reported in Wuhan, China in December 2019, COVID-19 has spread to all the continents at an unprecedented pace.
Salar Hafez Ghoran +3 more
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Inhibitors of sphingolipid metabolism enzymes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006 Sphingolipids are a family of lipids that play essential roles both as structural cell membrane components and in cell signalling. The cellular contents of the various sphingolipid species are controlled by enzymes involved in their metabolic pathways. In this context, the discovery of small chemical entities able to modify these enzyme activities in a
Amadeu Llebaria +4 more
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Carbazole scaffolds in cancer therapy: a review from 2012 to 2018
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products.
Samar Issa +6 more
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