Results 21 to 30 of about 5,417,177 (410)

Flavivirus enzymes and their inhibitors

, 2021
Flaviviruses such as dengue, Japanese encephalitis, West Nile, Yellow Fever and Zika virus, cause viral hemorrhagic fever and encephalitis in humans. However, antiviral therapeutics to treat or prevent flavivirus infections are not yet available. Thus, there is pressing need to develop therapeutics and vaccines that target flavivirus infections.
Marc C. Morais, Ekaterina Knyazhanskaya, Kyung H. Choi   +2 more
openaire   +4 more sources

S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors

Molecules, 2023
We previously reported dipeptidomimetic compounds as inhibitors of neuronal and/or inducible NO synthases (n/iNOS) with significant selectivity against endothelial NOS (eNOS).
Elodie Mauchauffée, Jérémy Leroy, Jihanne Chamcham, Abdelaziz Ejjoummany, Manon Maurel, Lionel Nauton, Booma Ramassamy, Karima Mezghenna, Jean-Luc Boucher, Anne-Dominique Lajoix, Jean-François Hernandez   +10 more
doaj   +1 more source

Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide [PDF]

, 2010
A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site.
Bohno, Calmes, Chimni, Cohen, Corey, Dahlin, Daugirdas Tomas Racys, Dean Rea, Esnouf, Fletcher, Fulop, Fulop, Goebel, Grellier, Gribkov, Guanti, Hargaden, Hart, Honma, Kanai, Kondo, Lawandi, Li, Macías, Maes, Martin Wills, Molander, Mota, Murray, Murshudov, Padwa, Petit, Rea, Read, Saltsman, Sanchez-Sancho, Shan, Smith, Stehl, Stockel-Maschek, Vilmos Fülöp, Yoshimoto   +41 more
core   +1 more source

The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains

Antibiotics, 2023
Alginates play an important role in the resistance of mucoid strains of Pseudomonas aeruginosa to antibiotics, as well as their persistence by escaping the immune defense system.
Christian Hulen
doaj   +1 more source

From Zn to Mn: the study of novel manganese-binding groups in the search for new drugs against tuberculosis. [PDF]

, 2011
In most eubacteria, apicomplexans, and most plants, including the causal agents for diseases such as malaria, leprosy, and tuberculosis, the methylerythritol phosphate pathway is the route for the biosynthesis of the C(5) precursors to the essential ...
de Oliveira, César Augusto F, McCammon, J Andrew, Vazquez, H, Williams, Sarah L   +3 more
core   +2 more sources

A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease

Journal of Functional Biomaterials, 2023
Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of function and death of nerve cells. A great deal of effort is being made to understand the pathogenesis of neurodegenerative diseases.
Mehtap Sahiner, Aynur Sanem Yilmaz, Buket Gungor, Nurettin Sahiner   +3 more
doaj   +1 more source

The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum [PDF]

, 2004
The discovery of a potentially novel proline-specific peptidase from bovine serum is presented which is capable of cleaving the dipeptidyl peptidase IV (DPIV) substrate Gly-Pro-MCA.
Abbott, Birney, Cunningham, De Meester, De Meester, Duke-Cohan, Duke-Cohan, Duke-Cohan, Durinx, Gilmartin, Hegen, Hopsu-Havu, Huang, Iwaki-Egawa, Kin, Laemmli, Malik, Mentlein, Mentlein, Ohkubo, Ohnishi, Pineiro-Sanchez, Scanlan, Schon, Sedo, Sedo, Shibuya-Saruta, Smith, Stockel-Maschek, Underwood, Yaron, Yoshimoto   +31 more
core   +1 more source

A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

EMBO Molecular Medicine, 2012
Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann, Nora Overlack, Fabian Möller, Valery Belakhov, Michiel van Wyk, Timor Baasov, Uwe Wolfrum, Kerstin Nagel‐Wolfrum   +7 more
doaj   +1 more source

Leishmania mexicana Trypanothione Reductase Inhibitors: Computational and Biological Studies

Molecules, 2019
Leishmanicidal drugs have many side effects, and drug resistance to all of them has been documented. Therefore, the development of new drugs and the identification of novel therapeutic targets are urgently needed.
Félix Matadamas-Martínez, Alicia Hernández-Campos, Alfredo Téllez-Valencia, Alejandra Vázquez-Raygoza, Sandra Comparán-Alarcón, Lilián Yépez-Mulia, Rafael Castillo   +6 more
doaj   +1 more source

Single-molecule theory of enzymatic inhibition predicts the emergence of inhibitor-activator duality [PDF]

Nature communications, 9(1), pp.1-9, 2018, 2016
The classical theory of enzymatic inhibition aims to quantitatively describe the effect of certain molecules -- called inhibitors -- on the progression of enzymatic reactions, but growing signs indicate that it must be revised to keep pace with the single-molecule revolution that is sweeping through the sciences.
arxiv   +1 more source