Results 21 to 30 of about 5,024,684 (342)

Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1

Molecules, 2015
The human 8-oxoguanine DNA glycosylase OGG1 is involved in base excision repair (BER), one of several DNA repair mechanisms that may counteract the effects of chemo- and radiation therapy for the treatment of cancer. We envisage that potent inhibitors of
Tushar R. Mahajan, Mari Eknes Ytre-Arne, Pernille Strøm-Andersen, Bjørn Dalhus, Lise-Lotte Gundersen   +4 more
doaj   +1 more source

Phytochemicals and Enzyme Inhibitory Capacities of the Methanolic Extracts from the Italian Apple Cultivar Mela Rosa dei Monti Sibillini

Pharmaceuticals, 2020
The phytochemical profile of the methanolic extracts (pulp and peel) obtained from two dehydration methods (drying and freeze-lyophilization) of the traditional Italian apple Mela Rosa dei Monti Sibillini, as well as their inhibitory properties against ...
Víctor López, Francisco Les, Serena Mevi, Joice Guileine Nkuimi Wandjou, Guillermo Cásedas, Giovanni Caprioli, Filippo Maggi   +6 more
doaj   +1 more source

Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study

British medical journal, 2018
Objective To determine whether the use of angiotensin converting enzyme inhibitors (ACEIs), compared with use of angiotensin receptor blockers, is associated with an increased risk of lung cancer. Design Population based cohort study.
Blánaid M. Hicks, K. Filion, H. Yin, L. Sakr, J. Udell, L. Azoulay   +5 more
semanticscholar   +1 more source

Angiotensin-Converting Enzyme Inhibitors [PDF]

The Journal of Clinical Hypertension, 2011
KEY POINTS AND RECOMMENDATIONS: •  In addition to hypertension, angiotensin-converting enzyme inhibitors are indicated for treatment of patients at high risk for coronary artery disease, after myocardial infarction, with dilated cardiomypathy, or with chronic kidney disease.
Joseph L. Izzo, Matthew R. Weir
openaire   +3 more sources

A REVIEW ON ENZYME INHIBITORS

International Research Journal Of Pharmacy, 2021
Enzymes play very important role in living organism as biocatalyst. They play vital role like secretion, metabolism, digestion, DNA functions, reproduction, conversation of molecules and many other functions of body. By inhibiting specific enzymes, we can cure numerous pathological conditions in humans like inhibiting HMG CoA reductase, we can decrease
Vipul Vaghela, Nikunj Patadiya, Nikita Panchal   +2 more
openaire   +1 more source

Cytosine-Based TET Enzyme Inhibitors.

ACS Medicinal Chemistry Letters, 2019
DNA methylation is known as the prima donna epigenetic mark for its critical role in regulating local gene transcription. Changes in the landscape of DNA methylation across the genome occur during cellular transition, such as differentiation and altered ...
Gabriella N. L. Chua, Kelly Wassarman, Haoyu Sun, Joseph A Alp, Emma I Jarczyk, Nathanael Kuzio, M. J. Bennett, Beth G. Malachowsky, M. Kruse, Andrew J. Kennedy   +9 more
semanticscholar   +1 more source

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

European Heart Journal, 2020
Aims The current pandemic coronavirus SARS-CoV-2 infects a wide age group but predominantly elderly individuals, especially men and those with cardiovascular disease. Recent reports suggest an association with use of renin–angiotensin–aldosterone system (
I. Sama, Alice Ravera, B. Santema, H. van Goor, J. T. ter Maaten, J. Cleland, M. Rienstra, A. Friedrich, N. Samani, L. Ng, K. Dickstein, C. Lang, G. Filippatos, S. Anker, P. Ponikowski, M. Metra, D. V. van Veldhuisen, A. Voors   +17 more
semanticscholar   +1 more source

Exploring N-acyl-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-enes as 11β-HSD1 Inhibitors

Molecules, 2018
We recently found that a cyclohexanecarboxamide derived from 4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene displayed low nanomolar inhibition of 11β-HSD1.
Rosana Leiva, Andrew McBride, Margaret Binnie, Scott P. Webster, Santiago Vázquez   +4 more
doaj   +1 more source

Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
New C-glycosides and α,β-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated.
Leonardo E. Riafrecha, Macarena S. Le Pors, Martín J. Lavecchia, Silvia Bua, Claudiu T. Supuran, Pedro A. Colinas   +5 more
doaj   +1 more source

Angiotensin-Converting Enzyme Inhibitors Induce Cough.

Turkish Thoracic Journal, 2019
Angiotensin-converting enzyme inhibitors (ACE-I) are widely used in diseases, such as hypertension, congestive heart failure, and myocardial infarction. Although these drugs are well tolerated, one out of five patients discontinues ACE-I due to drug side
I. Yilmaz
semanticscholar   +1 more source