Results 31 to 40 of about 5,417,177 (410)
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. [PDF]
, 2010 Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma.
Alex Berndt +16 more
core +2 more sources
Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study
British medical journal, 2018 Objective To determine whether the use of angiotensin converting enzyme inhibitors (ACEIs), compared with use of angiotensin receptor blockers, is associated with an increased risk of lung cancer. Design Population based cohort study.
Blánaid M. Hicks +5 more
semanticscholar +1 more source
European Heart Journal, 2020 Aims The current pandemic coronavirus SARS-CoV-2 infects a wide age group but predominantly elderly individuals, especially men and those with cardiovascular disease. Recent reports suggest an association with use of renin–angiotensin–aldosterone system (
I. Sama +17 more
semanticscholar +1 more source
Molecules, 2020 Peptidyl enzyme inhibitors containing an internal aminomethylphosphinic bond system (P(O)(OH)-CH2-NH) can be termed extended transition state analogs by similarity to the corresponding phosphonamidates (P(O)(OH)-NH).
Kamila Janiszewska +5 more
doaj +1 more source
Synthetic (p)ppGpp analogue is an inhibitor of stringent response in mycobacteria [PDF]
, 2017 Bacteria elicit an adaptive response against hostile conditions such as starvation and other kinds of stresses. Their ability to survive such conditions depends, in part, on stringent response pathways.
Bhardwaj, Neerupma +6 more
core +2 more sources
Cytosine-Based TET Enzyme Inhibitors.
ACS Medicinal Chemistry Letters, 2019 DNA methylation is known as the prima donna epigenetic mark for its critical role in regulating local gene transcription. Changes in the landscape of DNA methylation across the genome occur during cellular transition, such as differentiation and altered ...
Gabriella N. L. Chua +9 more
semanticscholar +1 more source
Angiotensin-Converting Enzyme Inhibitors [PDF]
The Journal of Clinical Hypertension, 2011 KEY POINTS AND RECOMMENDATIONS: • In addition to hypertension, angiotensin-converting enzyme inhibitors are indicated for treatment of patients at high risk for coronary artery disease, after myocardial infarction, with dilated cardiomypathy, or with chronic kidney disease.
Joseph L. Izzo, Matthew R. Weir
openaire +3 more sources
International Research Journal Of Pharmacy, 2021 Enzymes play very important role in living organism as biocatalyst. They play vital role like secretion, metabolism, digestion, DNA functions, reproduction, conversation of molecules and many other functions of body. By inhibiting specific enzymes, we can cure numerous pathological conditions in humans like inhibiting HMG CoA reductase, we can decrease
Vipul Vaghela +2 more
openaire +1 more source
Novel FXa Inhibitor Identification through Integration of Ligand- and Structure-Based Approaches
Molecules, 2017 Factor Xa (FXa), a vitamin K-dependent serine protease plays a pivotal role in the coagulation cascade, one of the most interesting targets for the development of new anticoagulants. In the present work, we performed a virtual screening campaign based on
Carlos F. Lagos +4 more
doaj +1 more source
Cysteine-10 on 17 β-Hydroxysteroid dehydrogenase 1 has stabilizing interactions in the cofactor binding region and renders sensitivity to sulfhydryl modifying chemicals [PDF]
, 2013 17 β-Hydroxysteroid dehydrogenase type 1 (17 β -HSD1) catalyzes the conversion of estrone to the potent estrogen estradiol. 17 β -HSD1 is highly expressed in breast and ovary tissues and represents a prognostic marker for the tumor progression and ...
Atanasov, Atanas G. +3 more
core +3 more sources