Results 121 to 130 of about 8,754,571 (337)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Inhibitory Effect Of Oxadiazooles And Thiadiazoles In Vitro On Serum Alkaline Phosphatase Enzyme Of Pregnant Woman [PDF]
, 2012 To assess the inhibitory effect of oxadiazole and thiadiazole derivatives on serum alkaline phosphatase level of pregnant in vitro. A cross-sectional study on 34 pregnant women was carried out at Al-Kadhumia Teaching Hospital. The mechanism of Inhibitory
Tawfeeq F. R. AL-Auqbi +1 more
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Universitas Scientiarum, 2009 Study of the inhibitory effect of Salvia scutellarioides extracts on the activity of the angiotensin-converting enzyme. Objective. Toidentify groups of secondary metabolites of Salvia scutellarioides present in the fraction with the greatest inhibitory ...
Gina Méndez-Callejas +3 more
doaj
Journal of Agricultural SciencesPolygonum species have strong biological activity due to their important bioactive components. Polygonum species have been studied for enzyme inhibition activity, wound healing, anti-inflammatory, antibacterial, antiviral, antioxidant effects ...
Tuğsen Büyükyıldırım +4 more
doaj +1 more source
Journal of Lipid Research, 1991 The influence of phospholipids on the activity of the soluble phosphatidate phosphohydrolase from rat liver was studied. Phosphatidylethanolamine stimulated the enzyme activity whereas phosphatidylglycerol, phosphatidylserine, and phosphatidylinositol ...
E Humble, L Berglund
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
The Effect of Hydration on Enzyme Activity and Dynamics [PDF]
, 2008 Water has long been assumed to be essential for biological function. To understand the molecular basis of the role of water in protein function, several studies have established a correlation between enzyme activity and hydration level. While a threshold
Lopez, Murielle
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2013 Casein and whey protein fractions from goat milk were hydrolysed by subtilisin and trypsin, individually and in combination, to release angiotensin converting enzyme (ACE)-inhibitory peptides.
F. Javier Espejo-Carpio +4 more
semanticscholar +1 more source