Results 101 to 110 of about 8,754,571 (337)

Analysis of Phytochemical Composition and Biological Activities of Verbascum cheiranthifolium var. cheiranthifolium stem and flowers

International Journal of Secondary Metabolite, 2018
Within this study phytochemical composition, antioxidant and enzyme inhibitory activities of extracts obtained from stem and flower of Verbascum cheiranthifolium var. cheiranthifolium were analysed.
Abdullah Dalar, Aydin Sukru Bengu, Oruc Allahverdiyev   +2 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Production of angiotensin-I-converting enzyme (ACE) inhibitory activity in milk fermented with probiotic strains: Effects of calcium, pH and peptides on the ACE-inhibitory activity

, 2011
Recently, probiotic fermented milk products have raised interest regarding their potential anti-hypertensive activity mainly due to the production of angiotensin-I-converting enzyme (ACE) inhibitory peptides.
Gonzalez Gonzalez, C. R., Gonzalez-Gonzalez, C. R., Jauregi, P., C.R. Gonzalez-Gonzalez, K.M. Tuohy, Tuohy, K. M., Tuohy, Kieran Michael, P. Jauregi   +7 more
core   +1 more source

Synthesis, in vitro enzyme kinetics and molecular docking studies of the 2-formylphenyl sulfonates and their hydrazone derivatives as potential anti-diabetic and anti-inflammatory agents

Results in Chemistry
The in vitro anti-diabetes and anti-inflammatory inhibitory activities of the synthesized 2-formylphenyl sulfonates and their hydrazone derivatives were evaluated through enzymatic assays as potential α-glucosidase and lipoxygenase (LOX-15) inhibitors ...
Emmanuel N. Agbo, Redolf S. Segodi, N.J. Gumede, Kgomotso W. Poopedi, Tlabo C. Leboho, W. Nxumalo   +5 more
doaj   +1 more source

Phytochemistry and biological activity of Onosma rascheyana extracts (Boiss.)

International Journal of Plant Based Pharmaceuticals, 2022
In recent years, it has been determined that Onosma species exhibit interesting biological/pharmacological activities. The aim of this study was to analyze the chemical composition, antioxidant and enzyme inhibitory activities of the methanol (MeOH ...
Cengiz Sarikurkcu, Ersin Demir, Mehmet Sabih Ozer, Riza Binzet   +3 more
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

In vitro acetylcholinesterase inhibition by psoralen using molecular docking and enzymatic studies

Journal of Pharmacy and Bioallied Sciences, 2015
Introduction: Alzheimer′s disease (AD) has increased at an alarming rate and is now a worldwide health problem. Inhibitors of acetylcholinesterase (AChE) leading to inhibition of acetylcholine breakdown constitute the main therapeutic strategy for AD ...
Gauresh Somani, Chinmay Kulkarni, Prashant Shinde, Rupesh Shelke, Kirti Laddha, Sadhana Sathaye   +5 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Purification and characterization of angiotensin converting enzyme-inhibitory derived from crocodile blood hydrolysates

, 2019
Various enzyme types were used to hydrolyze crocodile blood peptides showing an Angiotensin I-converting enzyme (ACE) inhibitory activity. Alcalase hydrolysates (ALH) and Protease G6 hydrolysates (PG6H) showed the highest degree of hydrolysis ...
Somporn KATEKAEW (6098651), Arnon NGO-SON (6698453)   +1 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source