Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Enzyme Inhibitory Profile of I10H Analogues.
, 2016 Enzyme Inhibitory Profile of I10H Analogues.
Wei-Li Di (2278912) +3 more
core +1 more source
Assessment of angiotensin converting enzyme inhibitory activity and quality attributes of yoghurt enriched with Cinnamomum verum, Elettaria cardamomum, Beta vulgaris and Brassica oleracea. [PDF]
Saudi J Biol Sci, 2023 Abdullah R +5 more
europepmc +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Enhancing Multi-Enzyme Cascade Activity in Metal-Organic Frameworks via Controlled Enzyme Encapsulation [PDF]
To position multi‐enzymes in a core‐shell structure, the conventional layer‐by‐layer approach is often used. However, this method is time‐consuming and complex, requiring multiple steps and the isolation of intermediates at each stage.
Liang, Kang +4 more
core +1 more source
Results in ChemistryThirteen novel 1,2,3-triazole linked nucleobases (5a-m) were designed and efficiently synthesized as potential human enzyme inhibitors. The target compounds were synthesized by using Copper (I)-catalysed Huisgen-Sharpless-Meldal 1,3-dipolar cycloaddition
Aditya Aggarwal +4 more
doaj +1 more source
Angiotensin-I-Converting Enzyme Inhibitory Activity of Protein Hydrolysates Generated from the Macroalga Laminaria digitata (Hudson) JV Lamouroux 1813. [PDF]
Foods, 2022 Purcell D, Packer MA, Hayes M.
europepmc +1 more source
Onosma demirizii : Chemical composition, antioxidant and enzyme inhibitory activity
ChemistrySelectAbstract The primary objectives of the present work were to determine the chemical composition, antioxidant potential and enzyme inhibitory activity of three extracts derived from Onosma demirizii (Boraginaceae), including methanol, water and ethyl acetate, and to chemically
Mehmet Sabih Ozer +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source