Results 91 to 100 of about 3,149,059 (351)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tests of predictions made by the Equilibrium Model for the effect of temperature on enzyme activity [PDF]

, 2008
The Classical Model describing the effects of temperature on enzyme activity consists of two processes: the catalytic reaction defined by ΔG cat and irreversible inactivation defined by ΔG inact, this model however, does not account for the observed ...
Oudshoorn, Matthew Leslie
core  

Association of Enzyme Inhibition with Methods of Museum Skin Preparation

, 1997
Enzyme inhibition is commonly encountered when using molecular biological techniques on museum-prepared animal skin samples, and this problem is exacerbated by a lack of information on how particular skins have been prepared for preservation. This report:
Mark S. Willcox, David S. Jones, L. Malcolm Hall   +2 more
core   +1 more source

Synergistic effects of enzyme and microbial treatments on corn stover silage quality

Frontiers in Animal Science
IntroductionThis study aimed to investigate the effects of different enzyme preparations and microbial inoculants on the fermentation quality, sensory characteristics, and nutritional composition of corn stover after ensiling, with the objective of ...
Mengyue Zhou, Wei Ma, Meng Sun, Bin Wang, Jianwei Wei, Xinyue Liang, Chunqiang Wang, Ying Wang   +7 more
doaj   +1 more source

Protoplast isolation from Dictyopteris pacifica and Scytosiphon lomentaria, using a simple commercial enzyme preparation. [PDF]

J Genet Eng Biotechnol, 2021
Avila-Peltroche J, Won BY, Cho TO.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

MACiE: a database of enzyme reaction mechanisms. [PDF]

, 2005
SUMMARY: MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create
Gemma L. Holliday, Bartlett, G J, Noel M. O'Boyle, Janet M. Thornton, O'Boyle, N M, Peter Murray-Rust, John B. O. Mitchell, Holliday, G L, Almonacid, D E, Murray-Rust, P, Daniel E. Almonacid, Thornton, J M, Mitchell, John Blayney Owen, Gail J. Bartlett, Mitchell, John Blayney Owen; id_orcid   +14 more
core   +2 more sources

Glucuronides Hydrolysis by Intestinal Microbial β-Glucuronidases (GUS) Is Affected by Sampling, Enzyme Preparation, Buffer pH, and Species. [PDF]

Pharmaceutics, 2021
Ebuzoeme C, Etim I, Ikimi A, Song J, Du T, Hu M, Liang D, Gao S.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Quantitative and evolutionary global analysis of enzyme reaction mechanisms [PDF]

, 2015
The most widely used classification system describing enzyme-catalysed reactions is the Enzyme Commission (EC) number. Understanding enzyme function is important for both fundamental scientific and pharmaceutical reasons.
Nath, Neetika
core   +1 more source