Results 111 to 120 of about 925,011 (313)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effects of Enzyme Addition on the Processing Characteristics of Frozen Dough and the Quality of the Steamed Bread

Shipin gongye ke-ji
Quality deterioration issues, such as insufficient gas retention, a rough taste, and a propensity to collapse, are usually encountered in frozen dough and its prepared flour products.
Hongwei WANG, Qinyue NIE, Jingyue QIAO, Yu ZHANG, Huishan SHEN, Xingli LIU, Xuewei ZHAO, Hua ZHANG, Yanyan ZHANG   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Combined cross-sectional prospective study to identify barriers to adherence of pancreatic enzyme use in patients with cystic fibrosis

, 2007
Monitoring and adjusting dose requirements of pancreatic enzyme replacement therapy (PERT) are an integral part of the dietetic assessment of patients with CF.
Pearson, Clare Emma
core  

Mechanism of exogenous enzymes participation in the regulation of digestion and metabolism in model chickens

Frontiers in Veterinary Science
Experiments were performed on fistulas with duodenal cannula, which can reflect the function of the pancreas and are a model for studying digestion and metabolism when using biologically active additives.
Vladimir Vertiprakhov, Bayarma S. Dashieva, Alexei M. Grigoriev, Veronika D. Ashikhmina   +3 more
doaj   +1 more source

Effect of different enzymes， bacteria and compound enzyme bacteria preparations on tannin content in grape seed fermented feed

Siliao yanjiu, 2022
The effect of different enzymes, bacteria and compound enzyme bacteria preparations on tannin content in grape seed fermented feed were investigated.
Yan WANG, Guo-hong YUAN, Ping-ping DUAN, Li-dong ZHANG, Hui-juan GAO, Qi LI, Gui-shan XU   +6 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Enzyme-Lignin Nanocapsules Are Sustainable Catalysts and Vehicles for the Preparation of Unique Polyvalent Bioinks

, 2019
Reactive lignin nanocapsules catalyze a pigmentation reaction to furnish an innovative type of sustainable polyvalent bioink. In this nanodevice, the pigment, vehicle, binder, and additive are included in a single confined spherical space.
Eliana Capecchi (4682878), Calabrò, Giuseppe, Avitabile, Daniele, Pelosi, Claudia, Colantonio, Claudia, Claudia Colantonio (5498468), Davide Piccinino, Claudia Pelosi, Piccinino, Davide, Capecchi, Eliana, Bizzarri, Bruno Mattia, Davide Piccinino (4090624), Giuseppe Calabrò, Saladino, Raffaele, Bruno Mattia Bizzarri (2553112), Eliana Capecchi, Giuseppe Calabrò (6576608), Raffaele Saladino (34329), Daniele Avitabile, Daniele Avitabile (213626), Claudia Colantonio, Raffaele Saladino, Bruno Mattia Bizzarri, Claudia Pelosi (6576605)   +23 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source