Results 101 to 110 of about 3,149,059 (351)

Safety evaluation of the food enzyme preparation isomaltulose synthase from <i>Serratia plymuthica</i> strain Z12A. [PDF]

EFSA J, 2021
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Silano V, Barat Baviera JM, Bolognesi C, Cocconcelli PS, Crebelli R, Gott DM, Grob K, Lambré C, Lampi E, Mengelers M, Mortensen A, Rivière G, Steffensen IL, Tlustos C, Van Loveren H, Vernis L, Zorn H, Herman L, Aguilera J, Andryszkiewicz M, Kovalkovicova N, Liu Y, Chesson A.   +24 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Preparation and characterization of cross-linked enzyme aggregates of Saccharomyces cerevisiae invertase

, 2010
Preparation and characterization of cross-linked enzyme aggregates of Saccharomyces cerevisiae ...
V Ghodake (17302048), N Samant (17340112), C Kumar (13398018), A Kate (17340109), S Gadagkar (17340115), Sachin Talekar (13098366)   +5 more
core  

Removal of flatulence causing sugars in soymilk [PDF]

, 2009
The enzyme, alpha-galactosidase was extracted from peanuts using various buffers and solvents. The specific activity of soluble preparation of peanut ranged from 0.0083 to 0.0606 U/mg.
Rajan, Anila
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Parameters in preparation and characterization of cross linked enzyme aggregates (CLEAs)

, 2013
Parameters in preparation and characterization of cross linked enzyme aggregates ...
G Joshi (14627573), S Kambale (17274310), Sachin Talekar (13098366), A Joshi (7673459), P Kamat (17302015), R Haripurkar (17302018)   +5 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effect of probiotics and enzymes on growth performance， slaughter performance， serum biochemical indices and immune organs index of Dagu chickens

Siliao yanjiu, 2022
The experiment was conducted to investigate the effect of different doses of probiotics and enzymes in diets on performance, slaughter performance and serum biochemical indices of Dagu chickens.
LI Wan-jun
doaj  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Method of Enzyme Production from the Hepatopancreas of the Red King Crab (Paralithodes camtschaticus): The Effect of Temperature and Defatting Conditions on Enzymatic Activity

Applied Sciences
Processing crabs for meat generates large quantities of waste (secondary raw materials). Internal organs are typically discarded, which causes environmental problems and highlights the need for the integrated use of marine bioresources. The red king crab
Vitaly Yu. Novikov, Kira S. Rysakova, Ivan A. Basalaev, Svetlana R. Derkach   +3 more
doaj   +1 more source