Results 81 to 90 of about 3,149,059 (351)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Influence of cellulolytic preparation on the productive qualities of snails of the Helix Aspersa Maxima species [PDF]

Технологія виробництва і переробки продуктів тваринництва
Heliciculture is a branch of animal husbandry that deals with cultivation and using edible terrestrial snails for food and cosmetic purposes. This type of animal husbandry has an advantage over others in terms of simplicity of technology, as snails do ...
Glavatchuk V.A., Ogorodnichuk H.M.
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Investigation of biochemical indicators of “Maisky” dog-rose fruits (Rosa Majalis) to choose methods for their processing

Новые технологии, 2018
The relevance of the researched problem is determined by the fact that dog-rose fruits contain vitamin C in high concentrations, which has a number of unique beneficial properties, it is a natural antioxidant and detoxicant capable of removing ...
F. F. Kokaeva, D. N. Dzhatieva, T. B. Kolotiy, S. N. Edygova, G. Y. Arutyunova   +4 more
doaj  

The effect of commercial enzyme preparation-assisted maceration on the yield, quality, and bioactivity of essential oil from waste carrot seeds (Daucus carota L.)

Grasas y Aceites, 2014
Eight enzyme preparations were screened with a view to maximizing the yield of carrot seed essential oil. Three of the eight enzyme preparations investigated, lipase from Mucor circinelloides, XPect® pectinase, and Esperase® protease, significantly ...
K. B. Śmigielski, M. Majewska, A. Kunicka-Styczyńska, R. Gruska, Ł. Stańczyk   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An NADH dependent reductase for isolated enzyme and whole cell catalysis. [PDF]

, 2006
Isolated enzymes and whole cell biocatalysts can both be applied for the synthesis of chiral hydroxy compounds. It is hypothesized that whole cells can easily be employed for such reactions using simple technology which is robust.
Shorrock, Vicky Jane, Shorrock, V.J.
core  

Preparation of diglycerides by lipase-catalyzed alcoholysis of triglgicerides

, 1997
Lipase from Penicillium roquefortii immobilized on porous polypropylene particles was used for enzymatic preparation of 1,2-diglycerides by alcoholysis in organic media.
Bo Mattiasson, Mattiasson, Bo, Li Tian, Adlercreutz, Patrick, Millqvist Fureby, Anna, Anna Millqvist Fureby, Tian, Li, Patrick Adlercreutz, Tian, Li,, Adlercreutz, Patrick,   +9 more
core   +1 more source

Optimization of Enzymatic Assisted Extraction of Bioactive Compounds from Olea europaea Leaves

Biomass
Nowadays, the circular economy trend drives researchers in the recovery of various bioactive compounds from agri-food by-products. Enzyme-assisted extraction (EAE) has been shown to be an innovative green technology for the effective extraction of ...
Alexios Vardakas, Achilleas Kechagias, Nikolay Penov, Aris E. Giannakas   +3 more
doaj   +1 more source