Results 181 to 190 of about 2,217,916 (339)

Manipulating the Light Systemic Signal HY5 Greatly Improve Fruit Quality in Tomato

open access: yesAdvanced Science, EarlyView.
This study establishes that HY5, activated by low‐dose light, acts as a systemic signal to enhance tomato fruit quality by directly promoting carotenoid synthesis and sugar metabolism. These findings demonstrate HY5's mobility from leaves to fruits and its application potential through nighttime LED lighting, offering a practical strategy for crop ...
Jiachun Wang   +7 more
wiley   +1 more source

Studies on the Induction and Repression of Enzymes in Rat Liver

open access: hybrid, 1968
J P Jost   +2 more
openalex   +1 more source

Derepression and repression of the histidine operon: role of the feedback site of the first enzyme [PDF]

open access: bronze, 1975
Vanesa Fernández‐Sáiz   +4 more
openalex   +1 more source

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

open access: yesAdvanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin   +3 more
wiley   +1 more source

A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids

open access: yesJournal of Lipid Research, 2006
Paraoxonase-1 (PON1), an enzyme that metabolizes organophosphate insecticides, is secreted by the liver and transported in the blood complexed to HDL.
Diana M. Shih   +5 more
doaj  

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

open access: yesAdvanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang   +9 more
wiley   +1 more source

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