Results 121 to 130 of about 978,452 (311)

Evaluation of pancreatin stability through enzyme activity determination

Acta Pharmaceutica, 2016
Pancreatin is a biotechnological product containing an enzyme complex, obtained from porcine pancreas, that is employed in treating pancreatic diseases.
Terra Gleysson De Paula, Vinícius De Farias Marcus, Trevisan Marcello Garcia, Garcia Jerusa Simone   +3 more
doaj   +1 more source

Glycosylation increases active site rigidity leading to improved enzyme stability and turnover. [PDF]

FEBS J, 2023
Ramakrishnan K, Johnson RL, Winter SD, Worthy HL, Thomas C, Humer DC, Spadiut O, Hindson SH, Wells S, Barratt AH, Menzies GE, Pudney CR, Jones DD.   +12 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Local Conformational Constraint of Firefly Luciferase Can Affect the Energy of Bioluminescence and Enzyme Stability. [PDF]

CCS Chem, 2022
Zhang C, Bai X, Chen S, Dedkova LM, Hecht SM.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

ВЛИЯНИЕ РЕЖИМОВ ПРЕДВАРИТЕЛЬНОГО ЗАМОРАЖИВАНИЯ НА ЭФФЕКТИВНОСТЬ ЛИОФИЛИЗАЦИИ И АКТИВНОСТЬ ПРЕПАРАТА НА ОСНОВЕ КОЛЛАГЕНАЗ

Journal of Bioinformatics and Genomics
В работе исследовано влияние различных методов предварительного замораживания на эффективность последующей лиофилизации коллагеназы типа I и сохранение ее ферментативной активности.
Полякова А.О., Терлецкий В.П.   +1 more
doaj   +1 more source

Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability. [PDF]

J Biol Chem, 2022
Shukla PK, Sinha D, Leng AM, Bissell JE, Thatipamula S, Ganguly R, Radmall KS, Skalicky JJ, Shrieve DC, Chandrasekharan MB.   +9 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Aqueous ionic liquids redistribute local enzyme stability via long-range perturbation pathways. [PDF]

Comput Struct Biotechnol J, 2021
El Harrar T, Frieg B, Davari MD, Jaeger KE, Schwaneberg U, Gohlke H.   +5 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source