Results 41 to 50 of about 784,273 (205)

Combined miglustat and enzyme replacement therapy in two patients with type 1 Gaucher disease: two case reports

Journal of Medical Case Reports, 2018
Background Intravenous enzyme replacement therapy is a first-line therapy for Gaucher disease type 1, and substrate reduction therapy represents an oral treatment alternative.
Dominick Amato, Mary Anne Patterson
doaj   +1 more source

Enzyme-linked immunosorbent assay for urinary albumin at low concentrations

, 1987
We describe an enzyme-linked immunosorbent assay (ELISA) for urinary albumin. It requires only commercially available reagents, can detect as little as 16 micrograms of albumin per liter, and analytical recovery ranges from 92 to 116%.
Ress, K. M., Krämer, Bernhard K., Jesse, U., Schmülling, R. M., Risler, T.   +4 more
core   +1 more source

Natural Enzyme‐Loaded Polymeric Stealth Coating‐Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism‐Immuno‐Enzyme Dynamic Therapy

Advanced Science
Reducing L‐lactate levels in tumors is crucial for alleviating immunosuppression and enhancing treatment efficacy. Recently, bacteria have great potential in improving lactate levels in the tumor microenvironment due to their physiological properties ...
Liuzhou Mao, Bahriman Xarpidin, Rui Shi, Yuting Lin, Haohua Hu, Caisheng Wu, Zheng Luo, Yun‐Long Wu   +7 more
doaj   +1 more source

Mucopolysaccharidosis type II: Enzyme Replacement Therapy Efficiency

Вопросы современной педиатрии, 2020
Mucopolysaccharidosis type II (MPS II), or Hunter syndrome, is the hereditary lysosomal storage disease caused by pathological variants in IDS gene. Such variants lead to iduronate-2-sulfatase enzyme deficiency and glycosaminoglycan catabolism disorder ...
Nato D. Vashakmadze, Leyla S. Namazova-Baranova, Natalia V. Zhurkova, Ekaterina Yu. Zakharova, Grigory V. Revunenkov, Tina V. Lobjanidze, Marina A. Babaikina   +6 more
doaj   +1 more source

Enzyme-Responsive Mesoporous Ruthenium for Combined Chemo-Photothermal Therapy of Drug-Resistant Bacteria

, 2019
The rapid mutation of drug-resistant bacteria and the serious lag of development of new antibiotics necessitate research on novel antibacterial agents.
Xufeng Zhu (4688077), Jiawei Liu, Guanglong Yuan, Yanan Liu, Jie Liu, Ange Lin, Jiawei Liu (553742), Jie Liu (15128), Xu Chen (432759), Lanmei Chen, Lanmei Chen (1594708), Guanglong Yuan (6955061), Youcong Gong, Youcong Gong (6955058), Yanan Liu (114059), Ange Lin (6955055), Xu Chen, Xufeng Zhu   +17 more
core   +1 more source

Enzyme replacement therapy: efficacy and limitations

Italian Journal of Pediatrics, 2018
Enzyme replacement therapy (ERT) is available for mucopolysaccharidosis (MPS) I, MPS II, MPS VI, and MPS IVA. The efficacy of ERT has been evaluated in clinical trials and in many post-marketing studies with a long-term follow-up for MPS I, MPS II, and ...
Daniela Concolino, Federica Deodato, Rossella Parini   +2 more
doaj   +1 more source

Reduced costs with bisoprolol treatment for heart failure - An economic analysis of the second Cardiac Insufficiency Bisoprolol Study (CIBIS-II) [PDF]

, 2001
Background Beta-blockers, used as an adjunctive to diuretics, digoxin and angiotensin converting enzyme inhibitors, improve survival in chronic heart failure.
Tarjan, J., Brunhuber, W., McMurray, J., Klein, W., Edes, I., Bacquet, P., Csanády, Miklós, Karpati, P., Remme, W. J., Cserhalmi, L., Gesztesi, T., Merot, J. L., Levy, E., Paschen, B., Simon, K., McGuire, A., Szucs, T. D., Préda, István   +17 more
core   +1 more source

ROS‐Driven Nanoventilator for MRSA‐Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti‐Inflammation and Immunomodulation

Advanced Science
Hypoxia, inflammatory response and pathogen (bacterial or viral) infection are the three main factors that lead to death in patients with acute lung injury (ALI). Among them, hypoxia activates the expression of HIF‐1α, further exacerbating the production
Zheng Luo, Qi Wang, Xiaotong Fan, Xue Qi Koh, Xian Jun Loh, Caisheng Wu, Zibiao Li, Yun‐Long Wu   +7 more
doaj   +1 more source

Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia

Química Nova, 2006
Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with ...
Lorena Blau, Renato Farina Menegon, Man Chin Chung   +2 more
doaj   +1 more source

Persistent dyslipidemia in treatment of lysosomal acid lipase deficiency

Orphanet Journal of Rare Diseases, 2020
Background Lysosomal acid lipase deficiency (LALD) is an autosomal recessive inborn error of lipid metabolism characterized by impaired lysosomal hydrolysis and consequent accumulation of cholesteryl esters and triglycerides.
Amanda Barone Pritchard, Alanna Strong, Can Ficicioglu   +2 more
doaj   +1 more source