Results 51 to 60 of about 784,273 (205)

Delayed angioedema during therapy with angiotensin-converting enzyme inhibitors [PDF]

Vojnosanitetski Pregled, 2011
Introduction. Angiotensin-converting enzyme inhibitors are leading cause of drug-induced angioedema, with incidence of 0.1 to 0.2%. The angioedema is not of immune nature; in predisposed individuals it is caused by accumulation of vasoactive mediators
Janković Slobodan M., Stefanović Srđan M.   +1 more
doaj   +1 more source

Reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy

, 2013
Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce.
Miró Meda, José M. (José María), 1956-, Cardellach, Francesc, López Moreno, Sònia, Martínez, Esteban, Blanco, José L., Milinkovic, Ana, Rodríguez Santiago, Benjamín, Gatell, José M., Nunes Martínez, Virginia, Casademont i Pou, Jordi, Miró i Andreu, Òscar   +10 more
core   +1 more source

A Chaperone Enhances Blood α-Glucosidase Activity in Pompe Disease Patients Treated With Enzyme Replacement Therapy

, 2014
Enzyme replacement therapy is currently the only approved treatment for Pompe disease, due to acid α-glucosidase deficiency. Clinical efficacy of this approach is variable, and more effective therapies are needed.
Della Casa R, RAVAGLIA, SABRINA MARIA, DELLA CASA, ROBERTO, Ombrone D, DE FILIPPI, PAOLA, Porto C, DANESINO, CESARE, Ravaglia S, PARENTI, GIANCARLO, Fecarotta S, ANDRIA, GENEROSO, FECAROTTA, SIMONA, la Marca G, ROMANO, ALFONSO, Pichiecchio A, MOLLICA, CARMINE, Donati MA, Andria G., ASCIONE, SERENA, Rossi B, Parenti G, Donati, MA, Rosa M, PORTO, CATERINA, De Filippi P, Morandi LO, Nusco E, Ascione S, Romano A, Danesino C, Mollica C, Agovino T, Sacchini M, Pasanisi MB   +33 more
core   +1 more source

NEDD8-conjugating enzyme E2s: critical targets for cancer therapy

Cell Death Discovery, 2023
NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F (UBE2F).
Lisha Zhou, Xiongzhi Lin, Jin Zhu, Luyi Zhang, Siyuan Chen, Hui Yang, Lijun Jia, Baofu Chen   +7 more
doaj   +1 more source

Reversal of life-threatening hepatopulmonary syndrome in Gaucher disease by imiglucerase enzyme replacement therapy

Molecular Genetics and Metabolism Reports, 2019
Advanced liver disease complicated by hepatopulmonary syndrome is a recognized complication of Gaucher disease. Macrophage-targeted, recombinant enzyme replacement therapy is effective in reversing clinical manifestations attributed to the accumulation ...
Amal El Beshlawy, Vagishwari Murugesan, Pramod Kumar Mistry, Khaled Eid   +3 more
doaj   +1 more source

Protein and cell therapy for lecithin-cholesterol acyltransferase (LCAT) deficiency [PDF]

, 2009
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme principally secreted by the liver into the circulation where it esterifies cholesterol and plays a key role in high- density lipoprotein (HDL) metabolism. In familial and acquired (liver disease)
Low, J K, Low, J.K.
core  

Chronic endometritis at present: focus on overcoming implantation failures

Клинический разбор в общей медицине
Chronic endometritis "from pathogenesis to therapy" still remains the most contrarian issue of modern gynaecology. The lack of a unified pathogenetic concept as well as diagnostic and therapeutic algorithms continue to support a multitude of scientific ...
Mekan R. Orazov, Viktor E. Radzinsky, Evgeny D. Dolgov   +2 more
doaj   +1 more source

Lentiviral vectors for gene therapy of Gaucher disease

, 2015
Gaucher disease (GD), a recessive disorder characterised by hepatosplenomegaly, pancytopenia and skeletal complications, is caused by deficiency of the enzyme glucocerebrosidase (GC).
Aitchison, KL
core  

Antibody–enzyme fusion proteins for cancer therapy

, 2011
Advances in biomolecular technology have allowed the development of genetically fused antibody–enzymes. Antibody–enzyme fusion proteins have been used to target tumors for cancer therapy in two ways.
Surinder K Sharma, Kerry A Chester, Carima Andrady   +2 more
core   +1 more source

Caricain: A basis for enzyme therapy for coeliac disease

South African Journal of Science, 2011
Gliadin, a glycoprotein present in wheat and other grass cereals, is a causative agent in coeliac disease. It is therefore important to find methods for the detoxification of gliadin.
Hugh Cornell, Teodor Stelmasiak
doaj