Results 181 to 190 of about 159,463 (305)

Synthesis and characterization of ZrFe₂O₄ and ZrFe₂O₄@UiO-66-NH₂ nanoparticles for efficient immobilization of <i>Humicola insolens</i> lipase: a comparative study of precipitation-crosslinking <i>versus</i> covalent binding methods. [PDF]

Nanoscale Adv
Azizi K, Ghasemi S, Nikseresht A.
europepmc   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Immobilization of a Fungal Fructosyltransferase onto Silica Gel and Glutaraldehyde-Functionalized Silica Gel for Biocatalytic Applications. [PDF]

ACS Omega
Zanetti Prado JP, Vieira AC, Maiorano AE, Fernandes S, Correa Basso R, Carvalho Maestrelli S, Ottoni CA, da Cunha Abreu Xavier M, Villalba Morales SA, Firmani Perna R.   +9 more
europepmc   +1 more source

Increased levels of two distinct elastase-like hydrolases in plasma during septicemia [PDF]

, 1983
Duswald, Karl-Heimo, Goldberg, David M., Jochum, Marianne, Nelles, L. P., Schnebli, H. P.   +4 more
core   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Covalent immobilization of Lepidium draba peroxidase on chitosan-coated magnetic nanoparticles and its application in glucose biosensing. [PDF]

Sci Rep
Sepahi-Baghan M, Asoodeh A, Riahi-Madvar A.   +2 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Membrane Biofouling: Current Understanding and Future Perspectives- An Overview. [PDF]

Curr Microbiol
Phillip N, Muleja AA, Motsa MM, Mamba BB, Nkambule TTI, Tshangana CS.   +5 more
europepmc   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Innovative Immobilization of <i>Aspergillus aculeatus</i> OI4C2 Fructosyltransferase on MANAE-Agarose Cross-Linked with Genipin for Enhanced Production of Fructooligosaccharides. [PDF]

J Agric Food Chem
Inagaki TS, de Andrades D, Souza Alves Picciarelli G, Polizeli MLTM, Poleto de Oliveira D, Pereira de Carvalho Junior V, Helfenstein Rother PD, Fabricio MF, Ayub MAZ, Hertz PF, Kadowaki MK.   +10 more
europepmc   +1 more source