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EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li   +21 more
wiley   +1 more source

Activated Carbon Functionalization for Lipase Immobilization: Characterization, Hydrolytic Activity, and Ethyl Lactate Synthesis. [PDF]

open access: yesAppl Biochem Biotechnol
Nascimento PA   +8 more
europepmc   +1 more source
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The bioengineering of immobilized enzymes

Biochimie, 1973
Summary The development of immobilized enzyme reactors depends especially on the efficient production of immobilized enzymes having a long active life under operational conditions. The effect of immobilization by adsorption or covalent-binding on the retention of enzyme activity is described.
M D, Lilly, S P, O'Neill, P, Dunnill
openaire   +2 more sources

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