Results 151 to 160 of about 4,721,201 (422)

Redesign of a novel d-allulose 3-epimerase from Staphylococcus aureus for thermostability and efficient biocatalytic production of d-allulose

Microbial Cell Factories, 2019
Background A novel d-allulose 3-epimerase from Staphylococcus aureus (SaDAE) has been screened as a d-allulose 3-epimerase family enzyme based on its high specificity for d-allulose.
Zhangliang Zhu, Dengke Gao, Chao Li, Ying Chen, Menglu Zhu, Xin Liu, Masaru Tanokura, Hui-Min Qin, Fuping Lu   +8 more
doaj   +1 more source

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

Molecular Oncology, EarlyView.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang, Hei Ip Hong, Victor C. Y. Mak, Yuan Zhou, Yiling Lu, Guanglei Zhuang, Lydia W. T. Cheung   +6 more
wiley   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Nature's therapy for COVID-19: Targeting the vital non-structural proteins (NSP) from SARS-CoV-2 with phytochemicals from Indian medicinal plants

Phytomedicine Plus, 2021
Background: Containing COVID-19 is still a global challenge. It has affected the ''normal'' world by targeting its economy and health sector. The effect is shifting of focus of research from life threatening diseases like cancer. Thus, we need to develop
Pratap Kumar Parida, Dipak Paul, Debamitra Chakravorty   +2 more
doaj  

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

Nucleic Acids Res., 2013
Peptidases, their substrates and inhibitors are of great relevance to biology, medicine and biotechnology. The MEROPS database (http://merops.sanger.ac.uk) aims to fulfill the need for an integrated source of information about these.
N. Rawlings, Matthew Waller, A. Barrett, A. Bateman   +3 more
semanticscholar   +1 more source

Novel Archaeal DNA Polymerase B from Domas Hot Spring West Java [PDF]

, 2015
Nine novel archaeal DNA polymerase genes from Domas Hot Spring, West Java have been cloned directly through the natural sample.
Akhmaloka, A., Hertadi, Rukman, Nurbaiti, Santi, Suharti, S., Warganegara, Fida Madayanti   +4 more
core  

ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON [PDF]

, 1957
Aaron Novick, Milton A. Weiner
openalex   +1 more source

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, EarlyView.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

Exploration of Trichoderma reesei as an alternative host for erythritol production

Biotechnology for Biofuels and Bioproducts
Background Erythritol, a natural polyol, is a low-calorie sweetener synthesized by a number of microorganisms, such as Moniliella pollinis. Yet, a widespread use of erythritol is limited by high production costs due to the need for cultivation on glucose-
Audrey Masi, Georg Stark, Johanna Pfnier, Robert L. Mach, Astrid R. Mach-Aigner   +4 more
doaj   +1 more source

Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.

Endocrine reviews, 2004
Significant advances have taken place in our knowledge of the enzymes involved in steroid hormone biosynthesis since the last comprehensive review in 1988.
A. Payne, D. B. Hales
semanticscholar   +1 more source