Results 151 to 160 of about 1,930,061 (319)

Substituted lin-benzopurines as inhibitors of tRNA-guanine transglycosylase: modulation of enzyme dimerization and replacement of water clusters

, 2013
Luzi Jakob Barandun
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Novel chemistry and structural perspectives in vitamin B₁₂-dependent radical SAM enzymes. [PDF]

Chem Sci
Berteau O, Teixeira Nunes M, Taraglio N, Legrand P, Benjdia A.   +4 more
europepmc   +1 more source

Author response: Exploring the expression patterns of palmitoylating and de-palmitoylating enzymes in the mouse brain using the curated RNA-seq database BrainPalmSeq

, 2022
Angela R. Wild, Peter William Hogg, Stéphane Flibotte, Glory G Nasseri, Rocio Hollman, Danya Abazari, Kurt Haas, Shernaz X. Bamji   +7 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Characterization of Recombinant GH 43 β-Xylosidases and a GH 3 β-Glucosidase from <i>Levilactobacillus brevis</i> for the Hydrolysis of Lignocellulose-Derived Substrates. [PDF]

J Microbiol Biotechnol
Vasquez R, Mendoza RM, Cañas VA, Song JH, Lee JS, Bagon B, Kang DK.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Dual-encoder contrastive learning accelerates enzyme discovery. [PDF]

Proc Natl Acad Sci U S A
Rocks JW, Truong DP, Rappoport D, Maddrell-Mander S, Martin-Alarcon DA, Lee TM, Crossan S, Goldford JE.   +7 more
europepmc   +1 more source

Extracellular matrix associated proteins and processing enzymes as urinary biomarkers of Chronic Kidney Disease [PDF]

, 2015
Michelle Da Silva Lodge
openalex  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source