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Annual Review of Immunology, 2021 The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo ...
Elizabeth A Jacobsen +2 more
exaly +2 more sources
Frontiers in Medicine, 2018 Bullous pemphigoid (BP) is an autoimmune blistering disease which carries a significant mortality and morbidity. While historically BP has been characterized as an IgG driven disease mediated by anti-BP180 and BP230 IgG autoantibodies, developments in ...
Kyle T Amber +2 more
exaly +2 more sources
Eosinophils and eosinophil-associated diseases: An update. [PDF]
Journal of Allergy and Clinical Immunology, 2017 The goal of this series is to offer a survey of the latest literature for clinicians and scientists alike, providing a list of important recent advances relevant to the broad field of allergy and immunology. This particular assignment was to cover the topic of eosinophils. In an attempt to highlight major ideas, themes, trends, and advances relevant to
Jeremy A O'Sullivan, B. Bochner
semanticscholar +3 more sources
Type 2 innate lymphoid cells control eosinophil homeostasis
Nature, 2013 Eosinophils are specialized myeloid cells associated with allergy and helminth infections. Blood eosinophils demonstrate circadian cycling, as described over 80 years ago, and are abundant in the healthy gastrointestinal tract.
Richard M Locksley +2 more
exaly +2 more sources
Transcription Factors in Eosinophil Development and As Therapeutic Targets
Frontiers in Medicine, 2017 Dynamic gene expression is a major regulatory mechanism that directs hematopoietic cell fate and differentiation, including eosinophil lineage commitment and eosinophil differentiation. Though GATA-1 is well established as a critical transcription factor
Patricia C. Fulkerson
exaly +3 more sources
Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. [PDF]
Journal of Experimental Medicine, 1994 Eosinophil accumulation is a prominent feature of allergic inflammatory reactions, such as those occurring in the lung of the allergic asthmatic, but the endogenous chemoattractants involved have not been identified.
Collins, PD +8 more
core +2 more sources
Vitamin D impedes eosinophil chemotaxis via inhibiting glycolysis-induced CCL26 expression in eosinophilic chronic rhinosinusitis with nasal polyps [PDF]
Cell Communication and SignalingBackground Chronic rhinosinusitis with nasal polyps (CRSwNP) is likely to relapse due to aberrant eosinophil infiltration. The deficiency of Vitamin D (VD) is associated with increased eosinophil infiltration in eosinophilic oesophagitis.
Weiqiang Huang +14 more
doaj +2 more sources
Eosinophil Secretion of Granule-Derived Cytokines
Frontiers in Immunology, 2014 Eosinophils are tissue-dwelling leukocytes, present in the thymus, and gastrointestinal and genitourinary tracts of healthy individuals at baseline, and recruited, often in large numbers, to allergic inflammatory foci and sites of active tissue repair ...
Lisa A Spencer +2 more
exaly +2 more sources
Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts
Biomedicines, 2022 Higher blood and sputum eosinophil counts are associated with a greater response to corticosteroids in COPD. Low blood eosinophil counts exhibit greater stability over time whereas higher counts demonstrate more variability.
Augusta Beech +2 more
doaj +1 more source
Eosinophils in eosinophilic pneumonia [PDF]
European Respiratory Journal, 1996 Idiopathic eosinophilic pneumonia (IEP) is an uncom-mon disease of unknown aetiology characterized by theaccumulation of eosinophils in the lung, variable bloodeosinophilia and peripheral opacities on the chest radio-gram. The response to steroid treatment is dramatic butrelapses are frequent, requiring the use of long-termsteroid treatment [1 ...
ALBERA, Carlo, P. GHIO
openaire +2 more sources