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Transcription Factors in Eosinophil Development and As Therapeutic Targets
Dynamic gene expression is a major regulatory mechanism that directs hematopoietic cell fate and differentiation, including eosinophil lineage commitment and eosinophil differentiation. Though GATA-1 is well established as a critical transcription factor
Patricia C. Fulkerson
exaly +3 more sources
Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts
Higher blood and sputum eosinophil counts are associated with a greater response to corticosteroids in COPD. Low blood eosinophil counts exhibit greater stability over time whereas higher counts demonstrate more variability.
Augusta Beech+2 more
doaj +1 more source
Eosinophils in eosinophilic pneumonia [PDF]
Idiopathic eosinophilic pneumonia (IEP) is an uncom-mon disease of unknown aetiology characterized by theaccumulation of eosinophils in the lung, variable bloodeosinophilia and peripheral opacities on the chest radio-gram. The response to steroid treatment is dramatic butrelapses are frequent, requiring the use of long-termsteroid treatment [1 ...
ALBERA, Carlo, P. GHIO
openaire +2 more sources
Haematological Predictors of Section Recovery in Dengue Cases [PDF]
Introduction: Dengue fever is associated with relative increase in haemoglobin, haematocrit and monocyte counts and reduction in platelet counts, eosinophil percentage and absolute eosinophil count.
Sushma Nayar+2 more
doaj +1 more source
Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth. [PDF]
MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate with eosinophil levels.
Thomas X Lu+9 more
doaj +1 more source
Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis [PDF]
Background Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic ...
Yeonu Choi+4 more
doaj +1 more source
Dermatomyositis with Eosinophils [PDF]
Dermatomyositis is an idiopathic inflammatory myopathy that often presents with symmetric proximal skeletal muscle weakness and characteristic skin findings. Typical skin biopsy findings include vacuolar changes of the basal layer, increased dermal mucin, and a predominantly lymphocytic infiltrate.
Isabella I. Sanchez+4 more
openaire +3 more sources
Clinical and Biological Markers in Hypereosinophilic Syndromes
Hypereosinophilic syndromes (HES) are rare, heterogeneous syndromes characterized by markedly elevated eosinophil counts in the blood and/or tissue and evidence of eosinophil-associated pathology. Although parasitic infections, drug hypersensitivity, and
Paneez Khoury+2 more
doaj +1 more source
A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. [PDF]
Using an in vivo test system, the role of the β1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic inflammatory reactions was investigated.
Lobb, RR+3 more
core +1 more source
Lenalidomide is an immunomodulatory drug that is administered commonly in patients with relapsed or refractory multiple myeloma (RRMM). Eosinophils have immunological functions, for instance, in allergic diseases and asthma. The purpose of this study was
Kazuhito Suzuki+5 more
doaj +1 more source