Results 91 to 100 of about 207,524 (425)
Airway Sensory Nerve Plasticity in Asthma and Chronic Cough
Frontiers in Physiology, 2021 Airway sensory nerves detect a wide variety of chemical and mechanical stimuli, and relay signals to circuits within the brainstem that regulate breathing, cough, and bronchoconstriction.
Matthew G. Drake +4 more
doaj +1 more source
Clinical significance of stratifying prostate cancer patients through specific circulating genes
Molecular Oncology, EarlyView.We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian +12 more
wiley +1 more source
Monoclonal antibodies in type 2 asthma : a systematic review and network meta-analysis [PDF]
, 2019 Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate.
De Feyter, Silke +4 more
core +1 more source
The transcription factor XBP1 is selectively required for eosinophil differentiation
Nature Immunology, 2015 The transcription factor XBP1 has been linked to the development of highly secretory tissues such as plasma cells and Paneth cells, yet its function in granulocyte maturation has remained unknown. Here we discovered an unexpectedly selective and absolute
Sarah E. Bettigole +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
Could Eosinophilia predict clinical severity in nasal polyps?
Multidisciplinary Respiratory Medicine, 2017 Background Although nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially ...
Figen Aslan +3 more
doaj +1 more source
Cellular Segmentation and Composition in Routine Histology Images using Deep Learning [PDF]
arXiv, 2022 Identification and quantification of nuclei in colorectal cancer haematoxylin \& eosin (H\&E) stained histology images is crucial to prognosis and patient management. In computational pathology these tasks are referred to as nuclear segmentation, classification and composition and are used to extract meaningful interpretable cytological and ...
arxiv
A new formulation of oral viscous budesonide in treating of paediatric eosinophilic oesophagitis: a pilot study [PDF]
, 2017 OBJECTIVES: Oral viscous budesonide is a recent therapeutic option for eosinophilic oesophagitis (EoE) compared with dietary restriction and inhaled steroids.
Amil, D. J. +8 more
core +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Eosinophil-Count-Derived Inflammatory Markers and Psoriasis Severity: Exploring the Link
DermatoPsoriasis is an immune-mediated disease, with various triggering factors, genetic predisposition, and an altered immune response concurring in the development of this disease.
Oana Mirela Tiucă +5 more
doaj +1 more source