Results 81 to 90 of about 110,785 (312)

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Shall We Focus on the Eosinophil to Guide Treatment with Systemic Corticosteroids during Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)? CON

Medical Sciences, 2018
The employment of systemic corticosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease (COPD) has been shown to improve airway limitation, decrease treatment failure and risk of relapse, and may improve symptoms in ...
Pedro J Marcos, José Luis López-Campos
doaj   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Prognostic Value of Eosinophil-Derived Hematological Indices in Acute Decompensated Heart Failure

Archives of Basic and Clinical Research
Objective: Eosinophil-derived hematological indices have been proposed as potential prognostic markers for cardiovascular disease; however, their clinical value in acute decompensated heart failure (ADHF) remains unclear.
Burak Kardeşler, Fikriye Kalkan
doaj   +1 more source

Goishi tea consumption inhibits airway hyperresponsiveness in BALB/c mice

BMC Immunology, 2011
Background Airway hyperresponsiveness (AHR) is one of the important traits that characterize bronchial asthma. Goishi tea is a post-heating fermented tea that has been reported to have higher free radical scavenging activity.
Nakamura Hiroyuki, Miyamura Mitsuhiko, Ngatu Nlandu R, Hirota Ryoji, Suganuma Narufumi   +4 more
doaj   +1 more source

Both fractional exhaled nitric oxide and sputum eosinophil were associated with uncontrolled asthma [PDF]

, 2018
Jie Gao, Zhaocheng Chen, Xiang Jie, Ruihua Ye, Feng Wu Department of Respiratory Medicine, The Third People’s Hospital, Guangzhou Medical College, Huizhou, People’s Republic of China Background: Sputum eosinophil and ...
Chen ZC, Gao J, Jie X, Wu F, Ye RH
core  

Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps [PDF]

, 2012
Thymic stromal lymphopoietin (TSLP) that is released by epithelial cells upon certain environmental triggers activates cells of the innate and adaptive immune system resulting in a preferential T helper 2 immune response.
Simon, H-U, S. Yousefi, Simon, D, Yousefi, S, Stöckle, C, H.-U. Simon, M. Morshed, C. Stöckle, D. Simon, Morshed, M   +9 more
core   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Blood Eosinophil and Risk of Exacerbation in Chronic Obstructive Pulmonary Disease Patients: A Retrospective Cohort Analysis

International Journal of COPD, 2020
Ming Chiu Chan, 1 Yiu Cheong Yeung, 1 Ellen Lok Man Yu, 2 Wai Cho Yu 1 1Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China; 2Clinical Research Centre, Princess Margaret Hospital, Hong Kong, ChinaCorrespondence: Ming ...
Chan MC, Yeung YC, Yu ELM, Yu WC
doaj  

Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis [PDF]

, 1994
To evaluate whether the eosinophil preformed mediators, eosinophil cationic protein X, and eosinophil-derived neurotoxin/eosinophil protein X (EDN/EPX) are detectable in serum and can be used as markers of eosinophilic ...
Tomassini, M, Stefano Bonini, Bonini, S, Alessandro Lambiase, Sergio Bonini, LAMBIASE, ALESSANDRO, Magrini, L, Margherita Tomassini, Bonini, S., Laura Magrini   +9 more
core   +1 more source