Results 91 to 100 of about 123,808 (307)

Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps

, 2012
Thymic stromal lymphopoietin (TSLP) that is released by epithelial cells upon certain environmental triggers activates cells of the innate and adaptive immune system resulting in a preferential T helper 2 immune response.
Simon, H-U, S. Yousefi, Simon, D, Yousefi, S, Stöckle, C, H.-U. Simon, M. Morshed, C. Stöckle, D. Simon, Morshed, M, Stöckle C, Yousefi S, Yousefi, Shida, Simon HU, Simon, Hans-Uwe, Morshed M, Morshed, Md. Mahbubul, Simon D, Simon, Dagmar   +18 more
core   +1 more source

Effect of GLP-1RA on blood eosinophil levels in adults: a real-world study

BMC Pulmonary Medicine
Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for glycemic control and weight management, especially semaglutide. Potential benefits of GLP-1RAs in asthma, especially in eosinophilic phenotypes, prompt growing scientific
Yiting Wu, Yi Lin, Jifei Wu, Lei Zhao, Yanmei Lin, Wenwen Chen, Yufan Zhu, Yufan Wang, Min Zhang, Wuping Bao   +9 more
doaj   +1 more source

Serum beta2-microglobulin and peripheral blood eosinophils for the assessment of severity and prognosis with omicron variant COVID-19 infection

Frontiers in Molecular Biosciences
BackgroundThe Omicron variant’s high transmissibility has made it the most widespread novel coronavirus variant. Elevated serum β2-MG levels from viral infections and EOS’ role in viral clearance have garnered attention.
Jie Tan, Hanxi Fang, Xiao Hu, Ming Yue, Junling Yang   +4 more
doaj   +1 more source

Non-specific activation of human eosinophil functional responses by vasoactive intestinal peptide

Allergology International, 2000
Eosinophils and neuropeptides are thought to play effector roles in allergic diseases, such as rhinitis; however, little is known about the biological effects of neuromediators, especially vasoactive intestinal peptide (VIP), on eosinophil functional ...
Amr El-Shazly, Keisuke Masuyama, Noriaki Tsunoda, Masao Eura, Takeru Ishikawa   +4 more
doaj   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Eosinophil Depletion with Benralizumab for Eosinophilic Esophagitis

New England Journal of Medicine
Benralizumab is an eosinophil-depleting anti-interleukin-5 receptor α monoclonal antibody. The efficacy and safety of benralizumab in patients with eosinophilic esophagitis are unclear.In a phase 3, multicenter, double-blind, randomized, placebo-controlled trial, we assigned patients 12 to 65 years of age with symptomatic and histologically active ...
Marc E Rothenberg 1, Evan S Dellon 1, Margaret H Collins 1, Albert J Bredenoord 1, Ikuo Hirano 1, Kathryn A Peterson 1, Laura Brooks 1, Julie M Caldwell 1, Harald Fjällbrant 1, Hanna Grindebacke 1, Calvin N Ho 1, Matthew Keith 1, Christopher McCrae 1, Dominic Sinibaldi 1, Wendy I White 1, Catherine J Datto 1, MESSINA Trial Investigators: Fabio Almerigogna, Ignacio Antepara Ercoreca, Ana María Alonso Llamazares, Laurent Alric, Dhandapani Ashok, Kevin Bax, Lindsey McLeish, María Basagaña Torrentó, Amir Ben Tov, Adi Anafy, Dmitry S Bordin, Elen R Valitova, Albert J Bredenoord, M Laura Haasnoot, Aaltje Lei, Marco Caminati, Mirna Chehade, Constanza Ciriza de Los Ríos, Steven Clayton, Anca Mihaela Safta, Prerana Williamson, Elżbieta Czkwianianc, Wit Danilkiewicz, Nicola De Bortoli, Santino Marchi, Evan Dellon, Anjan Dhar, Rafael Firszt, Natalia Filipof, Ronald Fogel, Yasuhiro Fujiwara, Beata Gawdis-Wojnarska, Maciej Gonciarz, Nirmala Gonsalves, Frédéric Gottrand, Matthieu Antoine, Ian M Gralnek, Matthieu Groh, Catherine Nizou, Mar Guilarte Clavero, Laura Company-Sapiña, Ingrid Johana Gil, Paula Galván-Blasco, Thirumazhisai Gunasekaran, Jamal Hayat, Samantha Baillie, Attah Ocholi, Abigail Seward, Enrico Heffler, Alessandro Repici, Gaia Pellegatta, Francesca Racca, Navneet Hundal, Norihisa Ishimura, Eiko Okimoto, Anand S Jain, Halley Fowler, Maria Janiak, Jayaprakash Kamath, Showkat Hossain, Sergey Kashin, Jun Kato, Sibylle Koletzko, Hannes Leon, Tobias Schwerd, Bartosz Korczowski, Michał Korczowski, Natalya Krasnopeeva, Santhosh Kumar, Guillaume Lefevre, Jaroslaw Leszczyszyn, John Leung, Evan Cunningham, Joel Liem, Lindsay Douglas, Tracey Bondy, Delina Copland, Amanda Vieira, Maxime Luu, Kristle Lee Lynch, Jonathan Matz, François Mion, Sabine Roman, Ziva Mrevlje-Roman, Zdenka Cipinova, Rosa Muñoz-Cano, Gemma Lopez, Jason Ohayon, Sibgha Rehman, Vaidehi Bhatt, Gurnoor Walia, Robert Pesek, Erin Thomas, Safin Attwal, Kathryn Peterson, Amy Holman, Mohammed Mannan, Anupama Ravi, Imad Absah, Puanani Hopson, Yehuda Ringel, Marc Rothenberg, Kara Kliewer, Cristin Murray Petzold, Vincent Mukkada, Phil Putnam, Scott Bolton, Justin Schwartz, Pablo Abonia, Erinn Kellner, Ashley Devonshire, Frederick Ruthardt, Cecilio Santander Vaquero, Sergio Casabona Francés, Teresa Pérez Fernandez, Verónica Martin Domínguez, Pedro Majano Rodriguez, Francisca Molina Jiménez, Jennifer Fernandez Pacheco, Ellen Sher, Gary Gross, Jacqueline Ross, Ulyana Trytko, Peter Siersema, Dareen Siri, María Luisa Somoza Álvarez, Kathrin Sprinzl, Anna Stanziola, Miguel Stein, Robert Szalewski, Vinay Mehta, Alexander Trukhmanov, Vladimir Ivashkin, Tatiana Lapina, Toshio Uraoka, Christoph Schlag, Simon Weidlich, Jörg Ulrich, Bas Weusten, Phillip Woodland, William Yang, Patrizia Zentilin, Manuele Furnari, Elisabetta Giuliana, Giorgia Bodini, Elisa Marabotto, Frank Zerbib, Noam Zevit, Maciej Żymła   +164 more
openaire   +5 more sources

[Evaluation of tissue eosinophils in eosinophilic pneumonia].

Nihon Kyobu Shikkan Gakkai zasshi, 1992
Transbronchial biopsy specimens from ten patients with eosinophilic pneumonia were analysed to see whether the tissue contained activated eosinophils or secreted eosinophil cationic protein. The specimens showed many infiltrated tissue eosinophils in the intraalveolar spaces, and thickened alveolar septae and perivascular areas.
Hamada, Kaoru, Nishikawa, Kiyoshi, Ako, Hirofumi, Morii, Takeshi, Kunimatsu, Mikikazu, Cho, Sumito, Tokuyama, Takeshi, Narita, Nobuhiro   +7 more
openaire   +2 more sources

Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context

Animal Models and Experimental Medicine, EarlyView.
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Osayd Zohud, Aysar Nashef, Imad Abu‐Elnaaj, Fuad A. Iraqi   +3 more
wiley   +1 more source

Relationship Between Peripheral Blood Eosinophil Count, Tissue Eosinophil Dominance and Serum Specific Immunoglobulin E Levels with Primary Chronic Rhinosinusitis Phenotype [PDF]

Background: European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) 2020 proposed a novel primary chronic rhinosinusitis (CRS) phenotype classification.
Riece HARIYATI, Krisna Dini SEPTIANI, Yanuar Iman SANTOSA, Anna Mailasari Kusuma DEWI, Kanti YUNIKA   +4 more
core   +2 more sources

Effect of benralizumab on inflammation in skin after intradermal allergen challenge in patients with moderate-to-severe atopic dermatitis

Journal of Allergy and Clinical Immunology: Global
Background: Atopic dermatitis (AD) is a skin barrier dysfunction characterized by tissue eosinophilia. Objective: In patients with AD, we evaluated the effect of eosinophil depletion with benralizumab on markers of inflammation in skin after intradermal ...
Christiane E. Whetstone, BSc, Ruth P. Cusack, MB, MPH, Emma Price, MSc, Karen Howie, Catie Stevens, BSc, Dhuha Al-Sajee, MD, PhD, Sue Beaudin, BSc, Jennifer Wattie, Nadia Alsaji, MBChB, Abbey Schlatman, BSc, Vanessa Luk, BHSc, Xiaotian Ju, PhD, Paul O’Byrne, MB, Mark Inman, MD, PhD, Roma Sehmi, PhD, Hermenio Lima, MD, PhD, Gail M. Gauvreau, PhD   +16 more
doaj   +1 more source