Results 51 to 60 of about 95,376 (339)

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Eosinophilia in school-going children with Plasmodium falciparum and helminth infections in the Volta region of Ghana

The Pan African Medical Journal, 2021
INTRODUCTION: Eosinophilia is seen in children infected with parasitic organisms. This study aimed at evaluating eosinophilia in children infected with Plasmodium falciparum, Schistosoma haematobium and intestinal helminths in the Volta Region of Ghana ...
Verner Ndudiri Orish, Jones Ofori-Amoah, Kokou Hefoume Amegan-Aho, Emmanuel Udochukwu Osisiogu, James Osei-Yeboah, Sylvester Yao Lokpo, Emmanuel Alote Allotey, Joseph Adu-Amankwaah, Daniel Edem Azuma, Percival Delali Agordoh   +9 more
doaj   +1 more source

Guideline for the investigation and management of eosinophilia

British Journal of Haematology, 2017
Nauman M. Butt, Jonathan Lambert, Sahra Ali, Philip A. Beer, Nicholas C. P. Cross, Andrew Duncombe, Joanne Ewing, Claire N. Harrison, Steven Knapper, Donal McLornan, Adam J. Mead, Deepti Radia, and Barbara J.
N. Butt, J. Lambert, Sahra Ali, P. Beer, N. Cross, A. Duncombe, J. Ewing, C. Harrison, S. Knapper, D. Mclornan, A. Mead, D. Radia, B. Bain   +12 more
semanticscholar   +1 more source

Classification of Myelodysplastic, Myeloproliferative, and Myelodysplastic/Myeloproliferative Neoplasms: The Past, Present, and Future

American Journal of Hematology, EarlyView.
ABSTRACT With the recent publication of new classification systems of hematopoietic neoplasms, understanding how recognition of disease entities has occurred over time and the subsequent development of formal disease classifications is of importance. This review focuses on the early recognition of myeloid disorders, especially chronic myeloid disorders,
Daniel A. Arber, Attilio Orazi
wiley   +1 more source

Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis

Gut, 2015
Consensus diagnostic recommendations to distinguish GORD from eosinophilic oesophagitis (EoE) by response to a trial of proton pump inhibitors (PPIs) unexpectedly uncovered an entity called ‘PPI-responsive oesophageal eosinophilia’ (PPI-REE).
J. Molina-Infante, A. Bredenoord, Edaire Cheng, E. Dellon, G. Furuta, S. Gupta, I. Hirano, D. Katzka, F. Moawad, M. Rothenberg, A. Schoepfer, S. Spechler, T. Wen, A. Straumann, A. Lucendo   +14 more
semanticscholar   +1 more source

Lung Adenocarcinoma with Paraneoplastic Hyper-Eosinophilia Not Responding To Pembrolizumab

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 2021
Background: Paraneoplastic hyper-eosinophilia associated with metastatic lung adenocarcinoma is a rare finding and has been associated with a poor prognosis when present.
Hisham Wehbe, Maria Kozah, Salwa A Koubaissi   +2 more
doaj   +1 more source

Hematological Neoplasms with Eosinophilia

Cancers, 2023
Eosinophils in peripheral blood account for 0.3–5% of leukocytes, which is equivalent to 0.05–0.5 × 109/L. A count above 0.5 × 109/L is considered to indicate eosinophilia, while a count equal to or above 1.5 × 109/L is defined as hypereosinophilia. In bone marrow aspirate, eosinophilia is considered when eosinophils make up more than 6% of the total ...
Rosario M. Morales-Camacho, Teresa Caballero-Velázquez, Juan José Borrero, Ricardo Bernal, Concepción Prats-Martín   +4 more
openaire   +4 more sources

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia

PLoS Pathogens, 2018
Eosinophils are effectors in immunity to tissue helminths but also induce allergic immunopathology. Mechanisms of eosinophilia in non-mucosal tissues during infection remain unresolved.
J. Turner, N. Pionnier, Julio Furlong-Silva, H. Sjoberg, Stephen Cross, A. Halliday, Ana F Guimaraes, Darren Cook, A. Steven, N. Van Rooijen, J. Allen, S. Jenkins, M. Taylor   +12 more
semanticscholar   +1 more source

Persistent Eosinophilic Inflammation Is Not a Feature of Type 2 CRS Patients Failing Anti‐IL‐5R Therapy and Requiring Class Switching to Anti‐IL‐4/13

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Type 2 inflammation dominates eosinophilic chronic rhinosinusitis (eCRS) and adult onset asthma. IL‐4, ‐5, and ‐13 are prominent disease mediators. Disease control can be achieved with biologic therapies. However, despite some patients entering remission, others experience poor control. Aim We aimed to describe eCRS patients treated
Peta‐Lee Sacks, Christian M Meerwein, Peter Earls, Cedric Thiel, Christine Choy, Raewyn G Campbell, Raymond Sacks, Larry Kalish, Richard J Harvey   +8 more
wiley   +1 more source

Eosinophilia in Very Low Birth Weight Infants

Pediatrics and Neonatology, 2010
Eosinophilia is common in premature infants, though its clinical significance remains unknown. This study investigated the pattern of eosinophilia and related factors in very low birth-weight (VLBW) infants.
Jui-Mei Yen, Chyi-Her Lin, Mei-Mei Yang, Shih-Ting Hou, Ai-Hsi Lin, Yuh-Jyh Lin   +5 more
doaj   +1 more source