Results 21 to 30 of about 7,611 (233)

S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis

Allergology International, 2023
Background: Chronic rhinosinusitis is classified into eosinophilic chronic rhinosinusitis (ECRS) and non-eosinophilic chronic rhinosinusitis (NECRS). ECRS is a refractory allergic disease involving a variety of immune and epithelial cells.
Ayaka Nakatani, Takeshi Tsuda, Yohei Maeda, Masaki Hayama, Daisuke Okuzaki, Sho Obata, Toshihiro Kishikawa, Kazuya Takeda, Hidenori Inohara   +8 more
doaj   +2 more sources

Eosinophilic granulomatosis with polyangiitis developed after dupilumab administration in patients with eosinophilic chronic rhinosinusitis and asthma: a case report

BMC Pulmonary Medicine, 2023
Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis characterized by eosinophil-rich granulomatous inflammation and small-to-medium vessel vasculitis associated ...
Isao Suzaki, Akihiko Tanaka, Ryo Yanai, Yuki Maruyama, Sawa Kamimura, Kojiro Hirano, Hitome Kobayashi   +6 more
doaj   +2 more sources

Is the measurement of ethmoid sinus dominance in eosinophilic chronic rhinosinusitis accurate? [PDF]

Brazilian Journal of Otorhinolaryngology
Objective: An ethmoid-dominant shadow on computed tomography is an indicator of type 2 inflammation, and is one of the main items used to diagnose and classify the severity of eosinophilic chronic rhinosinusitis in the Japanese diagnostic criteria ...
Kosuke Akiyama, Yasushi Samukawa, Hiroshi Hoshikawa   +2 more
doaj   +2 more sources

Alterations of nasal microbiome in eosinophilic chronic rhinosinusitis

Journal of Allergy and Clinical Immunology, 2023
Exposure to microbes may be important in the development of chronic rhinosinusitis (CRS). Dysbiosis of the nasal microbiome is considered to be related to CRS with nasal polyps (CRSwNP). The link between the nasal microbiota and eosinophilic CRSwNP (eCRSwNP) has rarely been studied.The aim of this study was to rigorously characterize nasal dysbiosis in
Runxiang Xie
exaly   +3 more sources

Dupilumab improves eosinophilic otitis media associated with eosinophilic chronic rhinosinusitis

Allergology International, 2023
Background: Eosinophilic otitis media (EOM) is a refractory condition associated with eosinophilic chronic rhinosinusitis and bronchial asthma. EOM is characterized by type-2 inflammation and is refractory to various treatments.
Daiki Nakashima, Tsuguhisa Nakayama, Syunsuke Minagawa, Tetsuya Adachi, Chieko Mitsuyama, Yoko Shida, Tsuneya Nakajima, Shin-ichi Haruna, Yoshinori Matsuwaki   +8 more
doaj   +3 more sources

Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings [PDF]

Allergology International, 2020
Background: Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis associated with asthma. CD69 is an important marker of activation for eosinophils.
Yasutaka Yun, Akira Kanda, Yoshiki Kobayashi, Dan Van Bui, Kensuke Suzuki, Shunsuke Sawada, Kazuyasu Baba, Masao Yagi, Mikiya Asako, Haruka Okazaki, Hiroki Ikeda, Shigeki Kawamura, Akihiko Nakamura, David Dombrowicz, Koichi Tomoda, Hiroshi Iwai   +15 more
doaj   +2 more sources

In office sampling of eosinophil peroxidase to diagnose eosinophilic chronic rhinosinusitis. [PDF]

Int Forum Allergy Rhinol
AbstractBackgroundPractical biomarkers for endotypic characterization of chronic rhinosinusitis (CRS) remain elusive, hindering clinical utility. Eosinophil peroxidase (EPX) is an enzyme released by activated eosinophils. The objective of this study was to evaluate a clinic EPX assay as a marker of eosinophilic CRS.MethodsSubjects with and without CRS ...
Callander JK, Charbit AR, Khanna K, Fahy JV, Tang M, Liegeois M, Pletcher SD, Goldberg AN, Gurrola JG, Murr AH, Butrymowicz A, Loftus PA.   +11 more
europepmc   +5 more sources

Alterations of gut microbiome in eosinophilic chronic rhinosinusitis. [PDF]

Eur Arch Otorhinolaryngol
A growing body of evidence has elucidated that the gut microbiota has a crucial impact on the pathophysiological process of atopic diseases. Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is a local atopic disease of the systemic immune response.
Liang Y, Zhang C, Xiong X, Mao X, Sun P, Yue Z, Wang W, Xie R, Zhang G.   +8 more
europepmc   +3 more sources

Eosinophil Peroxidase as a Dynamic Indicator of Treatment Response in Eosinophilic Chronic Rhinosinusitis. [PDF]

Int Forum Allergy Rhinol
Key Points Eosinophil peroxidase (EPX) correlates with local type 2 inflammation and may serve as a noninvasive biomarker of eosinophilic chronic rhinosinusitis ...
Callander JK, Charbit AR, Marshall C, Khanna K, Pletcher SD, Gurrola JG, Murr AH, Tang M, Goldberg AN, Loftus PA.   +9 more
europepmc   +3 more sources

IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients

Journal of Otolaryngology - Head and Neck Surgery, 2017
Background Eosinophilic chronic frontal sinusitis is difficult to treat compared with non-eosinophilic sinusitis because of recurring inflammation and polyp formation in the frontal recess after the post-operative follow-up period.
Kazunori Kubota, Sachio Takeno, Takayuki Taruya, Atsushi Sasaki, Takashi Ishino, Katsuhiro Hirakawa   +5 more
doaj   +2 more sources