Results 31 to 40 of about 6,813 (212)

Pathogenesis of chronic rhinosinusitis with nasal polyp and a prominent T2 endotype

Heliyon, 2023
Chronic rhinosinusitis is a heterogenous and multifactorial disease, characterized by persistent inflammation of the nose and paranasal sinuses, which causes nasal obstruction, nasal discharge, facial pain, and smell disturbance.
Said Ahmad Shah, Masayoshi Kobayashi
doaj   +1 more source

Omalizumab Restores Response to Corticosteroids in Patients with Eosinophilic Chronic Rhinosinusitis and Severe Asthma

Biomedicines, 2021
Eosinophilic chronic rhinosinusitis (ECRS), which is a subgroup of chronic rhinosinusitis with nasal polyps, is characterized by eosinophilic airway inflammation extending across both the upper and lower airways.
Yoshiki Kobayashi, Akira Kanda, Dan Van Bui, Yasutaka Yun, Linh Manh Nguyen, Hanh Hong Chu, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Hiroshi Iwai   +9 more
doaj   +1 more source

Epigenetics of chronic rhinosinusitis and the role of the eosinophil [PDF]

International Forum of Allergy & Rhinology, 2011
AbstractBackground:One theory for the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) involves aberration in the expression of genes that maintain the sinonasal innate immune system. We propose that the alteration in gene expression seen in CRSwNP is a result of oxidative byproducts of eosinophils.
Kristin A, Seiberling, Christopher A, Church, Jason L, Herring, Lawrence C, Sowers   +3 more
openaire   +2 more sources

The changes of clinical and histological characteristics of chronic rhinosinusitis in 18 years: Was there an inflammatory pattern shift in southern China?

World Allergy Organization Journal, 2021
Background: Nowadays, the heterogeneity of chronic rhinosinusitis (CRS) has attracted extensive attention. The histological patterns and clinical characteristics may vary greatly in different areas and among different groups of people.
Xin Luo, Zhaofeng Xu, Kejun Zuo, Jie Deng, Wenxiang Gao, Lijie Jiang, Lei Xu, Zhaoqi Huang, Jianbo Shi, Yinyan Lai   +9 more
doaj   +1 more source

The SWI/SNF complex in eosinophilic and non eosinophilic chronic rhinosinusitis

Acta Otorhinolaryngologica Italica, 2021
Chronic rhinosinusitis (CRS) can be classified as eosinophilic (eCRS) or non-eosinophilic (neCRS) based on infiltration type. The SWI/SNF complex may be involved in the pathophysiology of CRS.To assess the expression of the SWI/SNF complex in both CRS groups; to correlate blood eosinophil count (BEC), and histopathology eosinophil count (HPEC) with the
Katarzyna Kowalik, Martyna Waniewska-Leczycka, Elzbieta Sarnowska, Natalia Rusetska, Marcin Ligaj, Alicja Chrzan, Mariola Popko   +6 more
openaire   +4 more sources

Predictors of the enhanced response to mepolizumab treatment for severe eosinophilic asthma: A retrospective, long-term study

Cogent Medicine, 2020
Mepolizumab significantly reduces the number of annual exacerbations (AEs) and the maintenance dose of systemic corticosteroids (CSs) in patients with severe eosinophilic asthma (SEA).
Takanori Numata, Hanae Miyagawa, Hironori Kawamoto, Masahiro Yoshida, Hirofumi Utsumi, Mitsuo Hashimoto, Shunsuke Minagawa, Hiromichi Hara, Jun Araya, Kazuyoshi Kuwano   +9 more
doaj   +1 more source

Treatments of refractory eosinophilic lung diseases with biologics

Allergology International, 2023
Biologics targeting the molecules associated with type 2 inflammation have significantly improved the outcomes of patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).
Koichiro Asano, Yuzo Suzuki, Jun Tanaka, Konomi Kobayashi, Yosuke Kamide   +4 more
doaj   +1 more source

The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma

Allergy, Asthma & Clinical Immunology, 2011
This case reports the unique association of eosinophilic gastrointestinal disease with eosinophilic bronchitis, asthma and chronic rhinosinusitis and some features of lymphocytic hypereosinophilic syndrome, describes a diagnostic protocol for patients ...
Nair Parameswaran, Ochkur Sergei I, Protheroe Cheryl, Simms Elizabeth, Lee Nancy A, Lee James J   +5 more
doaj   +1 more source

Gαi1/3 signaling mediates IL-5-induced eosinophil activation and type 2 inflammation in eosinophilic chronic rhinosinusitis [PDF]

Frontiers in Immunology
Qingqing Jiao, Jiang Ji, Huanxia Xie
exaly   +2 more sources

Multiparametric Analysis of Factors Associated With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Ear, Nose & Throat Journal, 2022
Introduction: Previous studies have reported a diverse range of threshold values for blood eosinophilia. In addition, a single predictive biomarker for eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (ECRSwNP) has not yet been identified ...
Gian Luca Fadda MD, Andrea Galizia MD, Giuseppe Galizia PhD, Paolo Castelnuovo MD, Maurizio Bignami MD, Giovanni Cavallo MD   +5 more
doaj   +1 more source