Results 31 to 40 of about 1,778,131 (183)

Effectiveness of dupilumab treatment against refractory eosinophilic chronic rhinosinusitis [PDF]

Journal of Allergy and Clinical Immunology: Global
Tsuguhisa Nakayama, Daiki Nakashima, Shin-Ichi Haruna   +2 more
exaly   +2 more sources

The changes of clinical and histological characteristics of chronic rhinosinusitis in 18 years: Was there an inflammatory pattern shift in southern China?

World Allergy Organization Journal, 2021
Background: Nowadays, the heterogeneity of chronic rhinosinusitis (CRS) has attracted extensive attention. The histological patterns and clinical characteristics may vary greatly in different areas and among different groups of people.
Xin Luo, Zhaofeng Xu, Kejun Zuo, Jie Deng, Wenxiang Gao, Lijie Jiang, Lei Xu, Zhaoqi Huang, Jianbo Shi, Yinyan Lai   +9 more
doaj   +1 more source

Benralizumab in Patients With Severe Eosinophilic Asthma With and Without Chronic Rhinosinusitis With Nasal Polyps: An ANANKE Study post-hoc Analysis [PDF]

, 2022
Severe eosinophilic asthma (SEA) in the presence of chronic rhinosinusitis with nasal polyps (CRSwNP) indicates the presence of a more extensive eosinophilic inflammation.
Ori, Alessandra, Boarino, Silvia, Brussino, Luisa, Rogliani, Paola, Bracciale, Pietro, Canonica, Giorgio Walter, Schino, Pietro, Caruso, Cristiano, Senna, Gianenrico, D'Amato, Maria, Vultaggio, Alessandra, Bargagli, Elena, Menzella, Francesco, Di Marco, Fabiano, Pastorello, Elide Anna, Pelaia, Girolamo, Caiaffa, Maria Filomena, Simoni, Lucia, Vitiello, Gianfranco, Del Giacco, Stefano, Aliani, Maria, Romagnoli, Micaela, De Michele, Fausto, Centanni, Stefano, Altieri, Elena, Cristiano Caruso, Maria Filomena Caiaffa, Elena Altieri, Stefano Centanni, Gianenrico Senna, Pietro Bracciale, Fabiano Di Marco, Alessandra Ori, Francesco Menzella, Maria Aliani, Luisa Brussino, Lucia Simoni, Micaela Romagnoli, Maria D'Amato, Alessandra Vultaggio, Silvia Boarino, Paola Rogliani, Elide Anna Pastorello, Stefano Del Giacco, Pietro Schino, Fausto De Michele, Gianfranco Vitiello, Elena Bargagli, Giorgio Walter Canonica, Girolamo Pelaia   +49 more
core   +1 more source

Predictors of the enhanced response to mepolizumab treatment for severe eosinophilic asthma: A retrospective, long-term study

Cogent Medicine, 2020
Mepolizumab significantly reduces the number of annual exacerbations (AEs) and the maintenance dose of systemic corticosteroids (CSs) in patients with severe eosinophilic asthma (SEA).
Takanori Numata, Hanae Miyagawa, Hironori Kawamoto, Masahiro Yoshida, Hirofumi Utsumi, Mitsuo Hashimoto, Shunsuke Minagawa, Hiromichi Hara, Jun Araya, Kazuyoshi Kuwano   +9 more
doaj   +1 more source

Treatments of refractory eosinophilic lung diseases with biologics

Allergology International, 2023
Biologics targeting the molecules associated with type 2 inflammation have significantly improved the outcomes of patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).
Koichiro Asano, Yuzo Suzuki, Jun Tanaka, Konomi Kobayashi, Yosuke Kamide   +4 more
doaj   +1 more source

Impact of Chronic Rhinosinusitis with Nasal Polyposis on IL-12 and IL-8 [PDF]

Iranian Journal of Otorhinolaryngology, 2023
Introduction: The pathophysiology of Chronic Rhinosinusitis is coordinated by distinct inflammatory reactions in different individuals. Inflammatory environments with a predominance of Th2 lymphocytes tend also to be rich in eosinophils.
Jonatas do Amaral, Andrea David, Luciane Mello, Andre Luis Lacerda Bachi, Richard Louis Vogels, Andrew Thamboo, Rogério Pezato   +6 more
doaj   +1 more source

Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings

Allergology International, 2020
Background: Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis associated with asthma. CD69 is an important marker of activation for eosinophils.
Yasutaka Yun, Akira Kanda, Yoshiki Kobayashi, Dan Van Bui, Kensuke Suzuki, Shunsuke Sawada, Kazuyasu Baba, Masao Yagi, Mikiya Asako, Haruka Okazaki, Hiroki Ikeda, Shigeki Kawamura, Akihiko Nakamura, David Dombrowicz, Koichi Tomoda, Hiroshi Iwai   +15 more
doaj   +1 more source

Rethinking neutrophils and eosinophils in chronic rhinosinusitis [PDF]

, 2021
Chronic rhinosinusitis (CRS) often is characterized by an eosinophilic inflammatory pattern, nowadays referred to as type 2 inflammation, although the mucosal inflammation is dominated by neutrophils in about a third of the patients.
Simon, Hans-Uwe, Bochner, Bruce S, Bachert, C,, Delemarre, Tim, Bochner, Bruce S., Simon, H-U, Bachert, Claus, Delemarre, T, Bochner, BS, Claus Bachert, Bruce S. Bochner, Hans-Uwe Simon, Tim Delemarre   +12 more
core   +1 more source

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

Clinical Characteristics of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps in Adolescents

, 2023
Chien-Chia Huang,1,2 Po-Hung Chang,1,* Yen-Lin Huang,3– 5 Ta-Jen Lee,1,2,6 Chi-Che Huang,1,2 Pei-Wen Wu1,2,* 1Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; 2School of
Huang CC, Lee TJ, Wu PW, Huang YL, Chang PH   +4 more
core