Results 51 to 60 of about 1,674,898 (231)

Predictors of the enhanced response to mepolizumab treatment for severe eosinophilic asthma: A retrospective, long-term study

Cogent Medicine, 2020
Mepolizumab significantly reduces the number of annual exacerbations (AEs) and the maintenance dose of systemic corticosteroids (CSs) in patients with severe eosinophilic asthma (SEA).
Takanori Numata, Hanae Miyagawa, Hironori Kawamoto, Masahiro Yoshida, Hirofumi Utsumi, Mitsuo Hashimoto, Shunsuke Minagawa, Hiromichi Hara, Jun Araya, Kazuyoshi Kuwano   +9 more
doaj   +1 more source

The changes of clinical and histological characteristics of chronic rhinosinusitis in 18 years: Was there an inflammatory pattern shift in southern China?

World Allergy Organization Journal, 2021
Background: Nowadays, the heterogeneity of chronic rhinosinusitis (CRS) has attracted extensive attention. The histological patterns and clinical characteristics may vary greatly in different areas and among different groups of people.
Xin Luo, Zhaofeng Xu, Kejun Zuo, Jie Deng, Wenxiang Gao, Lijie Jiang, Lei Xu, Zhaoqi Huang, Jianbo Shi, Yinyan Lai   +9 more
doaj   +1 more source

Treatments of refractory eosinophilic lung diseases with biologics

Allergology International, 2023
Biologics targeting the molecules associated with type 2 inflammation have significantly improved the outcomes of patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).
Koichiro Asano, Yuzo Suzuki, Jun Tanaka, Konomi Kobayashi, Yosuke Kamide   +4 more
doaj   +1 more source

The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma

Allergy, Asthma & Clinical Immunology, 2011
This case reports the unique association of eosinophilic gastrointestinal disease with eosinophilic bronchitis, asthma and chronic rhinosinusitis and some features of lymphocytic hypereosinophilic syndrome, describes a diagnostic protocol for patients ...
Nair Parameswaran, Ochkur Sergei I, Protheroe Cheryl, Simms Elizabeth, Lee Nancy A, Lee James J   +5 more
doaj   +1 more source

Gαi1/3 signaling mediates IL-5-induced eosinophil activation and type 2 inflammation in eosinophilic chronic rhinosinusitis [PDF]

Frontiers in Immunology
Jisheng Liu, Huanxia Xie, Zhichen Liu
exaly   +2 more sources

Impact of Chronic Rhinosinusitis with Nasal Polyposis on IL-12 and IL-8 [PDF]

Iranian Journal of Otorhinolaryngology, 2023
Introduction: The pathophysiology of Chronic Rhinosinusitis is coordinated by distinct inflammatory reactions in different individuals. Inflammatory environments with a predominance of Th2 lymphocytes tend also to be rich in eosinophils.
Jonatas do Amaral, Andrea David, Luciane Mello, Andre Luis Lacerda Bachi, Richard Louis Vogels, Andrew Thamboo, Rogério Pezato   +6 more
doaj   +1 more source

Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings

Allergology International, 2020
Background: Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis associated with asthma. CD69 is an important marker of activation for eosinophils.
Yasutaka Yun, Akira Kanda, Yoshiki Kobayashi, Dan Van Bui, Kensuke Suzuki, Shunsuke Sawada, Kazuyasu Baba, Masao Yagi, Mikiya Asako, Haruka Okazaki, Hiroki Ikeda, Shigeki Kawamura, Akihiko Nakamura, David Dombrowicz, Koichi Tomoda, Hiroshi Iwai   +15 more
doaj   +1 more source

Role of P2X7R in eosinophilic and non‑eosinophilic chronic rhinosinusitis with nasal polyps

Molecular Medicine Reports, 2021
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammation‑mediated disease of the nasal mucosa. P2X7R has been reported to be a potential biomarker for inflammation. The aim of the present study was to explore the role of P2X7R in CRSwNP, and the interaction between P2X7R and the NLRP3 inflammasome in the development of CRSwNP.
Wang, Yan, Chen, Shan, Wang, Wenwen, Chen, Jianjun, Kong, Weijia, Wang, Yanjun   +5 more
openaire   +3 more sources

Eosinophilic chronic rhinosinusitis in East Asians

World Journal of Clinical Cases, 2014
Chronic rhinosinusitis (CRS) is a common disease worldwide, with a prevalence rate of 5%-15% in the general population. CRS is currently classified into two types: CRS with and without nasal polyps. CRS may also be divided into eosinophilic CRS (ECRS) and non-ECRS subtypes based on the presence of tissue eosinophilic infiltration or not.
En-Tong, Wang, Yan, Zheng, Peng-Fei, Liu, Li-Juan, Guo   +3 more
openaire   +2 more sources

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source