Results 61 to 70 of about 1,778,131 (183)

Efficacy of Endoscopic Sinus Surgery for Allergic Fungal Rhinosinusitis: A Systematic Review With Meta‐analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Endoscopic sinus surgery (ESS) plays a central role in the management of allergic fungal rhinosinusitis (AFRS); however, outcomes vary across studies. The goal of this study is to systematically review and synthesize evidence on the outcomes of ESS in patients with AFRS.
Amani Kais, Jad Kfouri, Ahmad R. Sedaghat, Charles Alex Riley, Chadi A. Makary   +4 more
wiley   +1 more source

Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps.

Chronic rhinosinusitis with nasal polyps is a heterogeneous disease and appropriate diagnostic algorithms in individual cases are necessary for effective medical treatment.The purpose of this study was to clarify the relationship between the pendrin ...
Suzuki, Keiko, 470, 471, Honda, Keiji, 472, Ito, Taku, 473, 474, 475, Kawashima, Yoshiyuki, 468, 469, Kitamura, Ken, Tsutsumi, Takeshi, Asamori, Tomoaki, Ikeda, Satoshi   +15 more
core   +2 more sources

Quantitative Real Time Polymerase Chain Reaction for measurement of human Interleukin – 5 receptor alpha spliced isoforms mRNA

BMC Biotechnology, 2003
Background Expression of human Interleukin-5 receptor alpha (hIL-5Rα) is controlled by alternative splicing, which generates two different transcripts encoding a membrane-anchored and a soluble form of the receptor, respectively.
Gevaert Philippe, Speleman Frank, Holtappels Gabriele, Vandenbroucke Ina, Vandesompele Jo, Pérez Claudina, Van cauwenberge Paul, Bachert Claus   +7 more
doaj   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, EarlyView.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Eosinophilic asthma with chronic rhinosinusitis/nasal polyps and biologic agents

, 2019
The current understanding in severe asthma management is the targeted therapy approach with the evaluation of phenotypes and biomarkers. Therefore, personalized treatments are recently more prominent. Eosinophilic asthma with chronic rhinosinusitis/nasal
YILMAZ, İNSU
core   +1 more source

Efficacy of mepolizumab treatment in oral corticosteroid-dependent severe eosinophilic asthma patients with chronic rhinosinusitis with nasal polyps: single center, real life study

, 2020
Background/aim: Oral corticosteroid (OCS)-dependent severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps (SEA-CRSwNP) would be a suitable phenotype for mepolizumab treatment. This study evaluated the short-term efficacy of mepolizumab
NAZİK BAHÇECİOĞLU, SAKİNE, YILMAZ, İNSU, TUTAR, NURİ, TÜRK, MURAT, GÜLMEZ, İNCİ, BAHÇECİOĞLU, SAKİNE NAZİK   +5 more
core   +1 more source

Severe eosinophilic asthma and aspirin-exacerbated respiratory disease associated to eosinophilic gastroenteritis treated with mepolizumab: a case report

Allergy, Asthma & Clinical Immunology, 2020
Background Mepolizumab (MEP) is the first anti Interleukin (IL)-5 add-on therapy approved for the treatment of severe refractory eosinophilic asthma. Case presentation We describe here the case of a 49 years-old woman with Aspirin-exacerbated respiratory
C. Caruso, S. Colantuono, D. Pugliese, C. Di Mario, B. Tolusso, E. Gremese, G. Papparella, F. Castrì, A. Gasbarrini, A. Romano, A. Armuzzi   +10 more
doaj   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Increase of high mobility group box chromosomal protein 1 in eosinophilic chronic rhinosinusitis with nasal polyps

, 2014
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by eosinophil-dominant infiltration in Europe and the United States. However, CRSwNP in Asia has shown different immunopathologic features.
Lei Chen, Mao, Mingfeng, Daishi Chen, Chen, Lei, Luisa M. Bellussi, Mingfeng Mao, Desiderio Passali, Bellussi, Luisa M, Passali, Desiderio, Chen, Daishi   +9 more
core   +1 more source

Insights into the Implications of Coexisting Type 2 Inflammatory Diseases

Journal of Inflammation Research, 2021
Justin P McCormick, Jivianne T Lee Department of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USACorrespondence: Jivianne T LeeDepartment of Head and Neck Surgery, University of California ...
McCormick JP, Lee JT
doaj