Results 71 to 80 of about 8,389 (161)

Prognostic Role of EMR1 in Lymph Nodes and Primary Tumors of Colon Cancer Patients

Advanced Biology, Volume 10, Issue 8, August 2026.
This study evaluated the prognostic value of the eosinophil biomarker EMR1 in 121 colon cancer patients. While high EMR1 levels in primary tumors correlated with improved survival, elevated levels in regional lymph nodes predicted poor outcomes. Combining EMR1 with CXCL17 further identified high‐risk patients.
Tamer Roshdy, Hagar Eltorky, Alaa Mohamed, Faten Zahran, Adel Guirgis, Lina Olsson, Gudrun Lindmark, Marie‐Louise Hammarström, Sten Hammarström, Basel Sitohy   +9 more
wiley   +1 more source

Eosinophilic Colitis: University of Minnesota Experience and Literature Review

Gastroenterology Research and Practice, 2011
Eosinophilic colitis is a rare form of primary eosinophilic gastrointestinal disease that is poorly understood. Neonates and young adults are more frequently affected.
Wolfgang B. Gaertner, Jennifer E. MacDonald, Mary R. Kwaan, Christopher Shepela, Robert Madoff, Jose Jessurun, Genevieve B. Melton   +6 more
doaj   +1 more source

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Correlation of the peripheral blood DNA methylation profile and immune‐related adverse events in patients with solid cancer treated with immune checkpoint inhibitors

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Baseline blood DNA methylation profiles predict early immune‐related adverse events across cancer types. A methylation‐based classifier demonstrated robust discriminatory performance and revealed enrichment of neuronal and developmental regulatory pathways, suggesting a systemic epigenetic predisposition to immune toxicity following immune checkpoint ...
Markus Kleinberger, Angelika Martina Starzer, Erwin Tomasich, Julia Maria Berger, Vincent Sunder‐Plassmann, Lynn Gottmann, Isabella Solano Henao, Martin Korpan, Josef Fuerst, Nikola Vladic, Cihan Ay, Helmuth Haslacher, Julia Furtner, Matthias Preusser, Gerwin Heller, Anna Sophie Berghoff   +15 more
wiley   +1 more source

Diagnosing Eosinophilic Colitis: Histopathological Pattern or Nosological Entity?

Scientifica, 2012
Reports of  “eosinophilic colitis”—raised colonic mucosal eosinophil density in patients with lower gastrointestinal symptoms—have increased markedly over the last fifteen years, though it remains a rarity.
Alan W. H. Bates
doaj   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Successful treatment of eosinophilic esophagitis with upadacitinib prescribed for atopic dermatitis

JPGN Reports, Volume 7, Issue 3, Page 449-451, August 2026.
Abstract We describe a pediatric patient treated with upadacitinib for atopic dermatitis (AD) who subsequently achieved sustained clinical and histologic remission of eosinophilic esophagitis (EoE). Upadacitinib is an oral small molecule selective Janus kinase 1 inhibitor that inhibits janus kinase‐signal transduction and activation of transcription ...
Nathalie Nguyen, Maureen Bauer
wiley   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Pellagra in Contemporary Clinical Practice (2000–2023): A Systematic Review

International Journal of Dermatology, Volume 65, Issue 8, Page 1590-1599, August 2026.
This systematic review (2000–2023) of 1212 cases highlights pellagra's evolving etiology. While primary dietary deficiency (85%) persists in humanitarian crises, secondary forms from alcohol misuse (9.6%), isoniazid (14.3% of drug‐related cases), and malabsorption are rising.
Noureddine Litaiem, Karama Sboui, Faten Zeglaoui   +2 more
wiley   +1 more source

Gastrointestinal: Eosinophilic colitis [PDF]

Journal of Gastroenterology and Hepatology, 2008
L S E, Shim, G D, Eslick, J S, Kalantar
openaire   +2 more sources