Results 191 to 200 of about 5,887,855 (243)

Three-year sustained remission with mepolizumab in a rare eosinophilic disease: idiopathic chronic eosinophilic pneumonia. [PDF]

Eur Clin Respir J
Akten HS, Inan S, Galata Z, Ozgur S, Ozeke Y, Gumusburun R, Demiroglu G, Goksel O.   +7 more
europepmc   +1 more source

Dual Host–Pathogen Screening of the Lung During Severe Influenza Using Spatial Transcriptomics

Immunology &Cell Biology, EarlyView.
We performed genome‐wide spatial transcriptomics at 10 μm resolution on the lungs of mice infected with influenza A virus. We utilised publicly available scRNAseq reference datasets to identify cell types present. We found viral transcripts across all detected cell types, suggesting localised indiscriminate infection.
Marcus Z. W. Tong, Oliver P. Skinner, Chen Zhu, Brooke J. Wanrooy, Ashlyn S. Kerr, Zheng Ruan, Cameron G. Williams, Heran Zhang, Linda M. Wakim, Ashraful Haque   +9 more
wiley   +1 more source

Unmet Needs and New Opportunities in Chronic Obstructive Pulmonary Disease in Italy: A Narrative Review with Insights from the GULP Study. [PDF]

Int J Chron Obstruct Pulmon Dis
Radovanovic D, Braido F, Contoli M, Corsico AG, Di Marco F, Micheletto C, Pelaia G, Rogliani P, Scichilone N, Solidoro P, Santus P.   +10 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Real-World Impact of Mepolizumab in COPD in a US Commercial and Medicare Claims Database. [PDF]

Int J Chron Obstruct Pulmon Dis
Panettieri RA, Paczkowski R, Mei H, Burrows E, Germain G, Shah S, Klimek J, Ma S, Cooper S, Laliberté F, Anzueto A.   +10 more
europepmc   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Treatment strategies for interstitial granulomatous dermatitis: Systematic review and expert opinion

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Systematic review of 108 studies with a total of 182 patients with interstitial granulomatous dermatitis (IGD). IGD was frequently associated with systemic conditions or drug exposure. Management includes careful medication review and prompt withdrawal of potential triggers. Corticosteroids (systemic and topical) were commonly effective, while biologic
Francesco Bellinato, Sara Salvagno, Chiara Colato, Paolo Gisondi, Giampiero Girolomoni   +4 more
wiley   +1 more source

Rescue of Eosinophilic Cardiac Tamponade by Anakinra in a Pregnant Woman With Familial Mediterranean Fever. [PDF]

Case Reports Immunol
Quaggetto M, Groh M, Savey L, Rouvier P, Moyon Q, Georgin-Lavialle S, Pineton de Chambrun M.   +6 more
europepmc   +1 more source

Low Allergic Sensitisation in Wheezing Children With Down Syndrome: A Case–Control Study

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Respiratory disorders are frequent in children with Down syndrome (DS), causing prolonged hospitalisations and increased healthcare system costs. Among these, recurrent wheezing is common in these children despite indications of lower rates of allergic sensitisation and asthma.
Francylene Malheiros Macedo da Cunha Rego, Geórgia Veras de Araújo Gueiros Lira, Emanuel Sávio Cavalcanti Sarinho, Patricia Gomes de Matos Bezerra, Marcilio Lins Aroucha, Igor Gabriel Araujo Medeiros, Decio Medeiros Peixoto   +6 more
wiley   +1 more source