Results 61 to 70 of about 712,631 (292)

Identification of specific EP receptors responsible for the hemodynamic effects of PGE₂

, 1999
To identify the E-prostanoid (EP) receptors that mediate the hemodynamic actions of PGE2, we studied acute vascular responses to infusions of PGE2using lines of mice in which each of four EP receptors (EP1through EP4) have been disrupted by gene ...
Thomas M. Coffman, Stephen L. Tilley, Mytrang Nguyen, Laurent P. Audoly, Mikelle Key, John D. McNeish, Beverly H. Koller, Jennifer Goulet, Jeffrey L. Stock   +8 more
core   +1 more source

A Novel Drug‐Loaded Porous Parylene Electrode for Targeted Anti‐Inflammatory Therapy and Hearing Preservation in Cochlear Implantation

Advanced Healthcare Materials, EarlyView.
A porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chi‐Chieh Chang, Ying‐Chang Lu, Yu‐Ming Chang, Yen‐Hui Chan, Hong‐Yu Yan, Yi‐Shan Lee, Pei‐Hsuan Lin, Cheng‐Yu Hsieh, Chuan‐Jen Hsu, Tien‐Chen Liu, Hsien‐Yeh Chen, Chen‐Chi Wu   +11 more
wiley   +1 more source

Cyclooxygenase-2 enhances α2β1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells

Molecular Cancer, 2010
Background Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP receptors on the surface of cancer cells has been reported to induce cancer ...
Hsu Chin-Jung, Yang Wei-Hung, Chen Hsien-Te, Huang Chun-Yin, Chang Chih-Shiang, Fong Yi-Chin, Liu Ju-Fang, Jeng Long-Bin, Chen Chih-Yi, Tang Chih-Hsin   +9 more
doaj   +1 more source

Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon [PDF]

British Journal of Pharmacology, 2008
Background and purpose: Lubiprostone (Amitiza), a possible ClC‐2 channel opener derived from prostaglandin E1 and indicated for the treatment of constipation, increases chloride ion transport and fluid secretion into the intestinal lumen. As lubiprostone may also directly modulate gastrointestinal motility, we investigated its actions and the possible ...
A K, Bassil, R A, Borman, E M, Jarvie, R J, McArthur-Wilson, R, Thangiah, E Z H, Sung, K, Lee, G J, Sanger   +7 more
openaire   +2 more sources

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

[Gastrointestinal cytoprotection by prostaglandin E and EP receptor subtypes].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001
Endogenous prostaglandins (PGs) play important roles in modulating the mucosal integrity and various functions of the gastrointestinal tract. Among them, E-type PGs are most effective in these actions. This article reviews recent studies dealing with the relationship of the cytoprotective action of PGE2- and EP-receptor subtypes in the gastrointestinal
K, Takeuchi, S, Kato, A, Tanaka
openaire   +4 more sources

Prostaglandin E2-Induced Cell Death is Mediated by Activation of EP2 Receptors in Motor Neuron-like NSC-34 Cells

Journal of Pharmacological Sciences, 2013
.: Prostaglandin E2 (PGE2) was shown to induce neuronal death in the CNS. To characterize the neurotoxicity of PGE2 and E-prostanoid receptors (EP) in motor neurons, we investigated PGE2-induced cell death and the type(s) of EP responsible for mediating ...
Hiroko Miyagishi, Yasuhiro Kosuge, Yuki Yoneoka, Maiko Ozone, Manami Endo, Nobuhiro Osada, Kumiko Ishige, Kuniko Kusama-Eguchi, Yoshihisa Ito   +8 more
doaj   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Functional prostaglandin E (EP) receptors in human penile corpus cavernosum [PDF]

International Journal of Impotence Research, 2003
In this study, we have characterized functional EP receptors in human corpus cavernosum (HCC) tissue and in HCC smooth muscle cells (SMC). Using RNase protection assays, we determined expression of EP2, EP3I and EP3II receptor mRNA. In organ bath preparations of HCC tissue strips, PGE1 caused dose-dependent relaxation at concentrations below 300 nM. At
R B, Moreland, N, Kim, A, Nehra, I, Goldstein, A, Traish   +4 more
openaire   +2 more sources

Purinergic receptors in skeletal muscles in health and in muscular dystrophy [PDF]

, 2014
The P2 purinergic (nucleotide) receptor super-family comprises of two families of protein. The P2X, which are channel-forming ionotropic receptors and the P2Y metabotropic receptors activating G protein-mediated signalling pathways.
Young, Christopher, Zablocki, Krzysztof, Rog, Justyna, Young, Christopher N. J., Rog, J., Gorecki, Dariusz, Zablocki, K., Krasowska, Elzbieta, Sinadinos, Anthony, Gorecki, Darek, Krasowska, E.   +10 more
core