Results 11 to 20 of about 28,018 (244)

3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma

open access: yesNature Communications, 2023
Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive molecular groups of ependymoma are the supratentorial ZFTA-fusion associated and the posterior fossa ependymoma group A.
Konstantin Okonechnikov   +50 more
doaj   +2 more sources

Adult intracranial ependymoma - relevance of DNA methylation profiling for diagnosis, prognosis and treatment.

open access: yesNeuro-Oncology, 2023
BACKGROUND A methylation-based classification of ependymoma has recently found broad application. However, the diagnostic advantage and implications for treatment decisions remain unclear.
M. Träger   +30 more
semanticscholar   +2 more sources

Tanycytic Ependymoma: A Challenging Histological Diagnosis [PDF]

open access: yesCase Reports in Neurological Medicine, 2013
Tanycytic ependymoma is a rare form of ependymoma that usually arises in the intramedullary spine. It has a unique histology emphasized by the inconspicuous ependymal pattern of cells and close resemblance to schwannoma and astrocytoma.
Khaled M. Krisht, Meic H. Schmidt
doaj   +2 more sources

Extramedullary Conus Ependymoma Involving a Lumbar Nerve Root with Filum Terminale Attachment

open access: yesClinical Medicine Insights: Case Reports, 2015
Purpose In the current report, we describe a case of an extramedullary ependymoma involving a lumbar nerve root near conus medullaris. Spinal ependymomas commonly present as intramedullary tumors in the cervical or thoracic cord or as tumors arising from
Takashi Moriwaki   +4 more
doaj   +2 more sources

Intraparenchymal clear cell ependymoma

open access: yesJournal of Cytology, 2011
Clear cell ependymoma (CCE) is an uncommon variant of ependymoma having a predilection for the supratentorial region. Histologically, it bears an uncanny resemblance to oligodendroglioma, central neurocytoma, hemangioblastoma and metastasis from clear ...
Prabal Deb   +3 more
doaj   +2 more sources

European genetic ancestry associated with risk of childhood ependymoma. [PDF]

open access: yesNeuro-Oncology, 2020
BACKGROUND Ependymoma is a histologically defined central nervous system tumor most commonly occurring in childhood. Population-level incidence differences by race/ethnicity are observed, with individuals of European ancestry at highest risk. We aimed to
Chenan Zhang   +21 more
semanticscholar   +2 more sources

The Pediatric Ependymoma Protein Database (PEPD)

open access: yesData in Brief, 2017
Proteomics, through application of modern high-end mass spectrometric (MS) approaches, offers the advantage of in-depth analysis of cancer tissues regarding their protein composition.
George Th. Tsangaris   +1 more
doaj   +2 more sources

Ependymoma: Evaluation and Management Updates

open access: yesCurrent Oncology Reports, 2022
To review state of art and relevant advances in the molecular genetics and management of ependymomas of children and adults. Ependymomas may occur either in the brain or in the spinal cord.
R. Rudà   +3 more
semanticscholar   +1 more source

ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma

open access: yesCancer Discovery, 2021
Over 60% of supratentorial (ST) ependymomas harbor a ZFTA-RELA (ZRfus) gene fusion (formerly C11orf95-RELA). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mouse brain.
A. Arabzade   +40 more
semanticscholar   +1 more source

Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma

open access: yesNature Communications, 2022
Pediatric ependymoma is a devastating brain cancer marked by its relapsing pattern and lack of effective chemotherapies. This shortage of treatments is due to limited knowledge about ependymoma tumorigenic mechanisms. By means of single-nucleus chromatin
Rachael G. Aubin   +6 more
semanticscholar   +1 more source

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