Results 31 to 40 of about 28,018 (244)

EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma

Acta Neuropathologica, 2021
Ependymomas (EPN) are tumors of the central nervous system (CNS) that can arise in the supratentorial brain (ST-EPN), hindbrain or posterior fossa (PF-EPN) or anywhere in the spinal cord (SP-EPN), both in children and adults.
Anne Jenseit, Aylin Camgöz, S. Pfister, M. Kool   +3 more
semanticscholar   +1 more source

Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma [PDF]

, 2018
Background: Epigenetic modifications have been shown to play an important role in the classification and pathogenesis of the pediatric brain tumor ependymoma, suggesting they are a potential therapeutic target.Results: Agents targeting epigenetic ...
Barron-Hastings, Jodie, Pajtler, Kristian W., Rogers, Hazel Anne, Grundy, Richard Guy, Sill, Martin, Chapman, Rebecca, Pfister, Stefan, Allard, Julie, Kings, Holly   +8 more
core   +1 more source

Ependymoma‐like tumor with mesenchymal differentiation harboring C11orf95‐NCOA1/2 or ‐RELA fusion: A hitherto unclassified tumor related to ependymoma

Brain Pathology, 2021
Recurrent fusion genes involving C11orf95, C11orf95‐RELA, have been identified only in supratentorial ependymomas among primary CNS tumors. Here, we report hitherto histopathologically unclassifiable high‐grade tumors, under the tentative label of ...
Ran Tomomasa, Y. Arai, Reika Kawabata-Iwakawa, Kohei Fukuoka, Y. Nakano, Natsuko Hama, Satoshi Nakata, N. Suzuki, Yukitomo Ishi, S. Tanaka, J. Takahashi, Y. Yuba, M. Shiota, A. Natsume, Michihiro Kurimoto, Yoshiki Shiba, M. Aoki, K. Nabeshima, Toshiyuki Enomoto, Tooru Inoue, J. Fujimura, Akihide Kondo, T. Yao, Naoki Okura, T. Hirose, A. Sasaki, M. Nishiyama, K. Ichimura, T. Shibata, J. Hirato, H. Yokoo, S. Nobusawa   +31 more
semanticscholar   +1 more source

Surgical outcome and prognostic factors in spinal cord ependymoma: a single-center, long-term follow-up study

Therapeutic Advances in Neurological Disorders, 2021
Objective: Spinal cord ependymomas account for 3–6% of all central nervous system tumors and around 60% of all intramedullary tumors. The aim of this study was to analyze the neurological outcome after surgery and to determine prognostic factors for ...
O. Gembruch, M. Chihi, Merle Haarmann, Ahmet Parlak, M. Oppong, L. Rauschenbach, Anna Michel, R. Jabbarli, Y. Ahmadipour, U. Sure, P. Dammann, N. Özkan   +11 more
semanticscholar   +1 more source

A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation

Cell Reports, 2018
Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supratentorial ependymoma, ST-EPN-RELA. Their model shows RELA-fusion-based de novo ependymoma tumorigenesis in the forebrain derived from neural stem cells. :
Kristian W. Pajtler, Stefan M. Pfister
doaj   +1 more source

TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma

Acta Neuropathologica, 2021
Subependymomas are benign tumors characteristically encountered in the posterior fossa of adults that show distinct epigenetic profiles assigned to the molecular group “subependymoma, posterior fossa” (PFSE) of the recently established DNA methylation ...
C. Thomas, F. Thierfelder, M. Träger, Patrick Soschinski, M. Müther, Dominic Edelmann, Alexandra Förster, Carola Geiler, Hee-yeong Kim, Katharina Filipski, P. Harter, J. Schittenhelm, F. Eckert, G. Ntoulias, S. May, W. Stummer, J. Onken, P. Vajkoczy, U. Schüller, F. Heppner, D. Capper, A. Koch, D. Kaul, W. Paulus, M. Hasselblatt, L. Schweizer   +25 more
semanticscholar   +1 more source

Adjunctive treatment of myxopapillary ependymoma running head: Myxopapillary ependymoma

Oncology Reviews, 2021
Myxopapillary ependymoma are rare tumors and optimal therapeutic strategy is remained controversial. The main treatments for myxopapillary ependymoma tumors include surgery and radiotherapy.
Amin Jahanbakhshi, Masoumeh Najafi, Fatemeh Jafari, Mahsa Moshtaghian, Marzieh Gomar, Mousareza Anbarlouei, Soheil Naderi   +6 more
doaj   +1 more source

C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation

Acta Neuropathologica Communications, 2021
Recurrent C11orf95-RELA fusions ( RELA FUS ) are the hallmark of supratentorial ependymomas. The presence of RELA as the fusion partner indicates a close association of aberrant NF-κB activity with tumorigenesis.
T. Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Y. Narita, T. Kondo, E. Holland, Ryuji Hamamoto, K. Ichimura   +9 more
semanticscholar   +1 more source

Ependymoma of conus medullaris presenting as subarachnoid haemorrhage [PDF]

, 2008
Subarachnoid haemorrhage (SAH) due to spinal ependymoma is very rare. We report a 37 year old man who presented with typical clinical signs of SAH.
Seifert, V, Beck, J, Marquardt, G, Ulrich, C T   +3 more
core   +1 more source

Ependymoma of the broad ligament mimicking an ovarian surface epithelial tumor

Radiology Case Reports, 2021
We report a case of ependymoma of the broad ligament occurring in a 21-year-old woman. CT and MRI findings showed a 40-mm-diameter, well-demarcated cystic mass with a lobulated solid component in the right pelvis. The solid component showed heterogeneous
Ryo Inukai, MD, Tatsuya Kawai, MD, Ryutaro Nishikawa, MD, Shino Ogawa, MD, Ryuji Kojima, MD, Nozomi Kita, MD, Hideo Hattori, MD, Yuta Shibamoto, MD   +7 more
doaj   +1 more source