Results 21 to 30 of about 18,048 (180)

Human Patient-Derived Brain Tumor Models to Recapitulate Ependymoma Tumor Vasculature

Bioengineering, 2023
Despite in vivo malignancy, ependymoma lacks cell culture models, thus limiting therapy development. Here, we used a tunable three-dimensional (3D) culture system to approximate the ependymoma microenvironment for recapitulating a patient’s tumor in ...
Min D. Tang-Schomer, Markus J. Bookland, Jack E. Sargent, Taylor N. Jackvony   +3 more
doaj   +1 more source

Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma [PDF]

, 2018
Background: Epigenetic modifications have been shown to play an important role in the classification and pathogenesis of the pediatric brain tumor ependymoma, suggesting they are a potential therapeutic target.Results: Agents targeting epigenetic ...
Barron-Hastings, Jodie, Pajtler, Kristian W., Rogers, Hazel Anne, Grundy, Richard Guy, Sill, Martin, Chapman, Rebecca, Pfister, Stefan, Allard, Julie, Kings, Holly   +8 more
core   +1 more source

A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation

Cell Reports, 2018
Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supratentorial ependymoma, ST-EPN-RELA. Their model shows RELA-fusion-based de novo ependymoma tumorigenesis in the forebrain derived from neural stem cells. :
Kristian W. Pajtler, Stefan M. Pfister
doaj   +1 more source

Ependymoma of conus medullaris presenting as subarachnoid haemorrhage [PDF]

, 2008
Subarachnoid haemorrhage (SAH) due to spinal ependymoma is very rare. We report a 37 year old man who presented with typical clinical signs of SAH.
Seifert, V, Beck, J, Marquardt, G, Ulrich, C T   +3 more
core   +2 more sources

Adjunctive treatment of myxopapillary ependymoma running head: Myxopapillary ependymoma

Oncology Reviews, 2021
Myxopapillary ependymoma are rare tumors and optimal therapeutic strategy is remained controversial. The main treatments for myxopapillary ependymoma tumors include surgery and radiotherapy.
Amin Jahanbakhshi, Masoumeh Najafi, Fatemeh Jafari, Mahsa Moshtaghian, Marzieh Gomar, Mousareza Anbarlouei, Soheil Naderi   +6 more
doaj   +1 more source

Ependymoma of the broad ligament mimicking an ovarian surface epithelial tumor

Radiology Case Reports, 2021
We report a case of ependymoma of the broad ligament occurring in a 21-year-old woman. CT and MRI findings showed a 40-mm-diameter, well-demarcated cystic mass with a lobulated solid component in the right pelvis. The solid component showed heterogeneous
Ryo Inukai, MD, Tatsuya Kawai, MD, Ryutaro Nishikawa, MD, Shino Ogawa, MD, Ryuji Kojima, MD, Nozomi Kita, MD, Hideo Hattori, MD, Yuta Shibamoto, MD   +7 more
doaj   +1 more source

A Rare Case of Metastatic Primary Peritoneal Ependymoma: A Case Report and Literature Review

Case Reports in Oncological Medicine, 2020
Background. Primary peritoneal ependymoma is an exceedingly rare tumour with only four cases reported in the literature. It typically follows an indolent disease course.
Ben Man Fei Cheung, Johnny Kin Sang Lau, Anthony W. I. Lo, Mai-Yee Luk, Kwok Keung Yuen   +4 more
doaj   +1 more source

3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma

Nature Communications, 2023
Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive molecular groups of ependymoma are the supratentorial ZFTA-fusion associated and the posterior fossa ependymoma group A.
Konstantin Okonechnikov, Aylin Camgöz, Owen Chapman, Sameena Wani, Donglim Esther Park, Jens-Martin Hübner, Abhijit Chakraborty, Meghana Pagadala, Rosalind Bump, Sahaana Chandran, Katerina Kraft, Rocio Acuna-Hidalgo, Derek Reid, Kristin Sikkink, Monika Mauermann, Edwin F. Juarez, Anne Jenseit, James T. Robinson, Kristian W. Pajtler, Till Milde, Natalie Jäger, Petra Fiesel, Ling Morgan, Sunita Sridhar, Nicole G. Coufal, Michael Levy, Denise Malicki, Charlotte Hobbs, Stephen Kingsmore, Shareef Nahas, Matija Snuderl, John Crawford, Robert J. Wechsler-Reya, Tom Belle Davidson, Jennifer Cotter, George Michaiel, Gudrun Fleischhack, Stefan Mundlos, Anthony Schmitt, Hannah Carter, Kulandaimanuvel Antony Michealraj, Sachin A. Kumar, Michael D. Taylor, Jeremy Rich, Frank Buchholz, Jill P. Mesirov, Stefan M. Pfister, Ferhat Ay, Jesse R. Dixon, Marcel Kool, Lukas Chavez   +50 more
doaj   +1 more source

Myxopapillary Ependymoma of the Cauda Equina in a 5-Year-Old Boy [PDF]

Asian Spine Journal, 2014
Myxopapillary ependymoma in childhood typically occurs in the central nervous system. There are few surgical cases of myxopapillary ependymoma of the cauda equina in children.
Masashi Uehara, Jun Takahashi, Keijiro Mukaiyama, Shugo Kuraishi, Masayuki Shimizu, Shota Ikegami, Toshimasa Futatsugi, Kenji Sano, Kazuhiro Hongo, Hiroyuki Kato   +9 more
doaj   +1 more source

Pediatric ependymomas: Something old, something new

Pediatric Hematology Oncology Journal, 2023
Ependymoma is one of the most common central nervous system (CNS) tumors in childhood. Ependymoma had previously been considered a single disease entity that arises in the posterior fossa, supratentorial compartment, or spinal cord; however recent ...
David N. Korones
doaj   +1 more source