Results 21 to 30 of about 28,018 (244)

Pediatric ependymoma: an overview of a complex disease

Child's Nervous System, 2021
Pediatric ependymomas comprise biologically distinct tumor entities with different (epi)genetics, age distribution and localization, as well as a different prognosis.
S. Jünger, B. Timmermann, T. Pietsch
semanticscholar   +1 more source

Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma

Cell Reports, 2020
Summary: Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual ependymomas is unknown. We perform multiplatform molecular profiling of 6 spatially distinct samples from an ependymoma with C11orf95-RELA fusion.
S. John Liu, Stephen T. Magill, Harish N. Vasudevan, Stephanie Hilz, Javier E. Villanueva-Meyer, Sydney Lastella, Vikas Daggubati, Jordan Spatz, Abrar Choudhury, Brent A. Orr, Benjamin Demaree, Kyounghee Seo, Sean P. Ferris, Adam R. Abate, Nancy Ann Oberheim Bush, Andrew W. Bollen, Michael W. McDermott, Joseph F. Costello, David R. Raleigh   +18 more
doaj   +1 more source

Delineation of molecular characteristics in pediatric PFA ependymoma involving rare osseous and pulmonary metastases: A case report and literature review

Frontiers in Oncology, 2022
Ependymoma is the third most common pediatric primary brain tumor, with its most aggressive subtype being posterior fossa group A (PFA). Extraneural metastasis of pediatric PFA ependymoma is rare.
Mading Zhou, Leiming Wang, Peng Sun, Yutong Liu, Ge Chen, Gao Zeng   +5 more
doaj   +1 more source

Locoregional delivery of CAR T-cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

Nature Medicine, 2020
Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently under clinical evaluation.
L. Donovan, A. Delaidelli, S. Joseph, K. Bielamowicz, Kristen Fousek, B. Holgado, A. Manno, Dilakshan Srikanthan, A. Gad, R. Ommeren, David Przelicki, Cory M. Richman, V. Ramaswamy, Craig Daniels, Jonelle G. Pallota, Tajana Douglas, Alyssa C. M. Joynt, J. Haapasalo, Carolina Nor, Maria C. Vladoiu, C. Kuzan-Fischer, L. Garzia, S. Mack, S. Varadharajan, M. Baker, Liam D. Hendrikse, Michelle Ly, Kaitlin Kharas, P. Balin, Xiaochong Wu, Lei Qin, Ning Huang, A. G. Stucklin, A. Morrissy, F. Cavalli, B. Luu, Raul A Suarez, P. Antonellis, Antony Michealraj, Avesta Rastan, M. Hegde, M. Komosa, O. Sirbu, Sachin A. Kumar, Zied Abdullaev, C. Faria, S. Yip, J. Hukin, U. Tabori, C. Hawkins, Kenneth D. Aldape, M. Daugaard, M. Daugaard, John M. Maris, John M. Maris, P. Sorensen, N. Ahmed, Michael D. Taylor   +57 more
semanticscholar   +1 more source

Supratentorial ependymoma in childhood: more than just RELA or YAP

Acta Neuropathologica, 2021
Two distinct genetically defined entities of ependymoma arising in the supratentorial compartment are characterized by the presence of either a C11orf95-RELA or a YAP-MAMLD1 fusion, respectively.
V. Zschernack, S. Jünger, M. Mynarek, S. Rutkowski, M. Garrè, M. Ebinger, M. Neu, J. Faber, B. Erdlenbruch, A. Claviez, S. Bielack, T. Brozou, M. Frühwald, E. Dörner, V. Dreschmann, A. Stock, L. Solymosi, J. Hench, S. Frank, Christian Vokuhl, A. Waha, F. Andreiuolo, T. Pietsch   +22 more
semanticscholar   +1 more source

Intracranial ependymoma [PDF]

Neurosurgical Focus, 2002
Object An intracranial ependymoma is a relatively rare but very interesting variety of glioma. In this paper, the authors compiled a review of the pathological features, imaging characteristics, and treatment strategies related to this brain tumor ...
Yaser A, Maksoud, Yoon S, Hahn, Herbert H, Engelhard   +2 more
openaire   +2 more sources

A rare case report of pituitary ependymoma

Interdisciplinary Neurosurgery, 2023
Ependymomas with pituitary localization are very rare in the adult age group. As a matter of fact, to date, only 13 cases of pathologically confirmed pituitary ependymoma have been reported.
Mehmet Melih Karaaslan, Alperen Sozer, Tugba Korpeoglu, Muammer Melih Sahin, Pelin Kuzucu, Emrah Celtikci   +5 more
doaj   +1 more source

Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04)

, 2022
BackgroundRelapsed ependymoma has a dismal prognosis, and the role of chemotherapy at relapse remains unclear. This study prospectively evaluated the efficacy of intensive intravenous (IV) etoposide in patients less than 21 years of age with relapsed ...
Wheatley, Keith, Macarthur, Donald, Ritzmann, Timothy A, Ellison, David W., Picton, Susan, Jaspan, Timothy, Grundy, Richard G, Veal, Gareth J, Apps, John R, Ellison, David W, Grundy, Richard G., Maycock, Shanna; id_orcid, Mallucci, Conor, Maycock, Shanna, Ritzmann, Timothy A., Veal, Gareth J., Apps, John R; id_orcid, Apps, John R.   +17 more
core   +1 more source

Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas

Acta Neuropathologica Communications, 2021
Primary spinal cord tumors contribute to ≤ 10% of central nervous system tumors in individuals of pediatric or adolescent age. Among intramedullary tumors, spinal ependymomas make up ~ 30% of this rare tumor population.
Margaret Shatara, Kathleen M. Schieffer, Darren Klawinski, Diana L. Thomas, Christopher R. Pierson, Eric A. Sribnick, Jeremy Jones, Diana P. Rodriguez, Carol Deeg, Elizabeth Hamelberg, Stephanie LaHaye, Katherine E. Miller, James Fitch, Benjamin Kelly, Kristen Leraas, Ruthann Pfau, Peter White, Vincent Magrini, Richard K. Wilson, Elaine R. Mardis, Mohamed S. Abdelbaki, Jonathan L. Finlay, Daniel R. Boué, Catherine E. Cottrell, David R. Ghasemi, Kristian W. Pajtler, Diana S. Osorio   +26 more
doaj   +1 more source

Human Patient-Derived Brain Tumor Models to Recapitulate Ependymoma Tumor Vasculature

Bioengineering, 2023
Despite in vivo malignancy, ependymoma lacks cell culture models, thus limiting therapy development. Here, we used a tunable three-dimensional (3D) culture system to approximate the ependymoma microenvironment for recapitulating a patient’s tumor in ...
Min D. Tang-Schomer, Markus J. Bookland, Jack E. Sargent, Taylor N. Jackvony   +3 more
doaj   +1 more source