Results 71 to 80 of about 19,186 (208)

Assessment of coronary artery outward remodeling in consequence of excision of epicardial adipose tissue in Ossabaw swine [PDF]

, 2017
Background Coronary artery disease (CAD) results from the buildup of cholesterol, inflammatory factors, and proliferating smooth muscle cells within a vessel wall. This plaque impedes on the vessel lumen, decreasing the space through which blood can flow,
Coderre, Kelly
core   +1 more source

Cardiac steatosis associates with visceral obesity in nondiabetic obese men. [PDF]

, 2013
Background: Liver fat and visceral adiposity are involved in the development of the metabolic syndrome (MetS). Ectopic fat accumulation within and around the heart has been related to increased risk of heart disease.
Adiels, Martin, Granér, Marit, Hakkarainen, Antti, Lauerma, Kirsi, Lundbom, Jesper, Lundbom, Nina, Nieminen, Markku S, Nyman, Kristofer, Pentikäinen, Markku O, Siren, Reijo, Taskinen, Marja-Riitta   +10 more
core   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Metabolic Shifts Induced by Treatment with Statin Influences Circulating Concentrations of the Stress Hormone, Cortisol, but Has Different Effects on Selected Cytokines, Adipokines and Neuropeptides in Lean and Fat Lines of Young Pigs

Metabolites
Background: It was hypothesized that short statin treatment would shift adipose expression, plasma and adipose tissue concentrations of adipokines and cytokines.
Krystyna Pierzchała-Koziec, Colin G. Scanes, Joanna Zubel-Łojek, Mirosław Kucharski   +3 more
doaj   +1 more source

Adipose Tissue Compartments, Inflammation, and Cardiovascular Risk in the Context of Depression

Frontiers in Psychiatry, 2022
The neurobiological and behavioral underpinnings linking mental disorders, in particular, major depressive disorder (MDD), with cardiovascular disorders are a matter of debate.
Britta Stapel, Maria Jelinic, Grant R. Drummond, Dagmar Hartung, Kai G. Kahl   +4 more
doaj   +1 more source

Adipose Tissue in SARS‐CoV‐2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update

Obesity, EarlyView.
Adipose tissue as a potential reservoir for and modifier of SARS‐CoV‐2 infection and its complications. Schematic demonstrating the differences in subcutaneous and visceral adipose tissue and infection capacity of SARS‐CoV‐2 with interplay between macrophages and adipocytes as target cells for viral tropism.
Liam Charles Maher, Paul M. Ryan, Noel M. Caplice   +2 more
wiley   +1 more source

AI-quantified epicardial adipose tissue and prediction of future myocardial infarction in patients with cardiometabolic disease: a post-hoc analysis from the SCOT-HEART trial

Cardiovascular Diabetology
Background Epicardial adipose tissue is gaining increasing interest as a cardiometabolic imaging biomarker, but its exact role in coronary artery disease is not fully understood. This study aimed to investigate the relationship between epicardial adipose
Jolien Geers, Nipun Manral, Caroline Park, Guadalupe Flores Tomasino, Kajetan Grodecki, Joel Lenell, Mikolaj Buchwald, Aryabod Razipour, Jacek Kwiecinski, Hidenari Matsumoto, Mohamed Marwan, Stephan Achenbach, Daniel S. Berman, Marc R. Dweck, David E. Newby, Piotr J. Slomka, Michelle C. Williams, Damini Dey   +17 more
doaj   +1 more source

3266 Understanding epicardial adipose biology by imaging, transcriptomic, and lipidomic profiling

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: The study aims to understand if pro inflammatory epicardial white adipose phenotype is positively associated with coronary atherosclerosis, while the brown adipose phenotype is negatively associated.
Jadranka Stojanovska, Alex Tsodikov, Carey Lumeng, Charles Burant, Thomas Chenevert   +4 more
doaj   +1 more source

Epigenetics and immunometabolism in diabetes and aging [PDF]

, 2018
Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core   +2 more sources

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source