Results 11 to 20 of about 2,351 (180)

Transitioning from epicutaneous to oral peanut immunotherapy

Frontiers in Allergy, 2023
IntroductionEpicutaneous immunotherapy (EPIT) has been tested in clinical trials for children with peanut allergy (PA) for its safety and efficacy in inducing desensitization.
Lauren Wong, Laurie Kost, Brent Anderson, Andrew Long, Sayantani B. Sindher, R. Sharon Chinthrajah, William J. Collins, William J. Collins   +7 more
doaj   +3 more sources

Anti-IgE therapy versus allergen-specific immunotherapy for food allergy: weighing the pros and cons [PDF]

Frontiers in Immunology
With the recent FDA approval of the anti-IgE biologic, omalizumab, in 2024 for the treatment of food allergy, it is critical to consider the advantages and disadvantages of anti-IgE and allergen-specific immunotherapies (AITs) to help determine optimal ...
Michael D. Kulis, Jessica R. Humphrey, James W. Krempski, Edwin H. Kim, Johanna M. Smeekens, Johanna M. Smeekens   +5 more
doaj   +2 more sources

Therapeutic perspectives in food allergy [PDF]

Journal of Translational Medicine, 2020
Background In the last twenty years, several studies have been conducted in the search for new therapeutic strategies in patients with food allergy; in particular, after the failure of injection immunotherapy, three different routes of administration ...
Francesco Marcucci, Chiara Isidori, Alberto Argentiero, Cosimo Neglia, Susanna Esposito   +4 more
doaj   +3 more sources

Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma. [PDF]

Allergy, 2021
Background Allergen-specific immunotherapy via the skin targets a tissue rich in antigen-presenting cells, but can be associated with local and systemic side effects.
Korotchenko E, Schießl V, Scheiblhofer S, Schubert M, Dall E, Joubert IA, Strandt H, Neuper T, Sarajlic M, Bauer R, Geppert M, Joedicke D, Wildner S, Schaller S, Winkler S, Gadermaier G, Horejs-Hoeck J, Weiss R.   +17 more
europepmc   +3 more sources

Eating away at food allergy. [PDF]

Pediatr Allergy Immunol
Fitness/endurance as an analogy to food desensitization. Both involve exposing the body to an activity initially poorly tolerated to gain capacity: In food treatments this is the capacity to eat more of the food and in exercise it is the capacity to exercise. When viewed as such it may not be surprising that with most currently available treatments the
Du YJ, Guo JC, Upton JEM.
europepmc   +2 more sources

Safety and Efficacy of Very Low-Dose Multi-Nut Oral Immunotherapy in Children. [PDF]

Clin Transl Allergy
ABSTRACT Background Oral immunotherapy (OIT) is a management strategy for food allergies, typically one at a time, with maintenance doses ≥ 300 mg protein. However, 30% of allergic children have multiple trigger foods, and large maintenance doses are associated with side effects. If efficacious, Very Low‐Dose OIT (VLOIT) may enhance safety in multi‐OIT.
Upton JEM, Li CH, Berenjy A, Galper A, Yin X, Celik A, Duan L, Wong S, Ditlof CM, San Diego KE, Hoang JA, Ben-Shoshan M, Kothari A, Hung L, Monteiro M, Phue WH, Moraes TJ, Eiwegger T.   +17 more
europepmc   +2 more sources

Mechanisms of desensitization with oral immunotherapy and epicutaneous immunotherapy. [PDF]

J Food Allergy, 2023
Background: Oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) are emerging therapies for food allergy. With several recently published exploratory trials and randomized controlled clinical trials that support these procedures, there is a clear progress and interest toward making these treatment options available for allergist ...
Bellanti JA.
europepmc   +3 more sources

European Medicines Agency (EMA) commentary on EMA/CHMP Guideline on allergen products development for immunotherapy and allergy diagnosis in moderate to low-sized study populations. [PDF]

Br J Clin Pharmacol
British Journal of Clinical Pharmacology, Volume 91, Issue 5, Page 1293-1296, May 2025.
Bonertz A, Drai C, Castelnovo T, Hartenstein D, Kaul S, Mitrevski M, Zubeldia JM.   +6 more
europepmc   +2 more sources

Food allergy: Epicutaneous immunotherapy. [PDF]

J Food Allergy, 2020
The goal of allergen-specific immunotherapy for treatment of immunoglobulin E (IgE) mediated food allergy is to safely and effectively modify the allergic response, providing protection against anaphylaxis via ongoing exposure to the triggering allergen.
Chow TG, Parrish C, Bird JA.
europepmc   +3 more sources

Epicutaneous Immunotherapy with CBir1 Alleviates Intestinal Inflammation. [PDF]

Inflamm Bowel Dis, 2023
Abstract Background Inflammatory bowel disease may be due to failed tolerance to normal gut bacteria. We demonstrate that epicutaneous immunotherapy (ET) to ovalbumin can alleviate colitis in murine models. However, most people are tolerant to or have anergy to ovalbumin.
Chen X, Elson CO, Dunkin D.
europepmc   +3 more sources