Results 41 to 50 of about 483,931 (267)

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Soldiers and epidemics [PDF]

Clinical Microbiology and Infection, 2012
Epidemics have accompanied wars since antiquity. They have often influenced the outcome of battles and military campaigns, and have occurred among both soldiers and civilians. Favourable conditions for their emergence result from the destruction caused by fighting, the social disorganization and collapse of health systems, the slackening of hygiene and
openaire   +2 more sources

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Integration of a social network strategy into index testing to increase HIV case finding among Haitian migrants and their descendants in the Dominican Republic

BMC Infectious Diseases
Introduction Increasing effectiveness, efficiency, and reach of HIV case-finding strategies among priority populations is essential for epidemic control.
Caterina Casalini, Molly Goggin-Kehm, Jacob Michel, Roudy Joseph, Ruth Diaz, Gianmarco Martinez, Stevenson Saint-Hilaire, Gercy Mateo, Chris Akolo, Navindra Persaud, Natasha Mack, Katherine Hernandez, Mario Reyes, Ceida Martinez, Leidy Tamarez, Mayra Elizardi, Maria Garcia, Algeni Lorenzo, Johana Molil, Elvis Baez, Rebecca Fertziger, Alejandro Soto   +21 more
doaj   +1 more source

Paronychia an Epidemic [PDF]

The American Journal of the Medical Sciences
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openaire   +3 more sources

The Obesity Epidemic [PDF]

AAOHN Journal, 2010
Obesity is common, serious, and costly. This epidemic has affected all of the United States. The related health care costs are staggering. However, many occupational health nurses have not yet implemented weight management programs at their companies or taken steps to improve their own health.
openaire   +2 more sources

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Fast-Tracking Vaccine Manufacturing: CEPI’s Rapid Response Framework for the 100 Days Mission

Vaccines
CEPI (the Coalition for Epidemic Preparedness Innovation)’s CMC rapid response framework is developed to support accelerated vaccine development, manufacturing, and roll-out for various outbreak scenarios to achieve the 100 Days Mission.
June Kim, Ramin Sabet-Azad, Dimki Patel, Gene Malin, Syed Hassan Askary, Anna Särnefält   +5 more
doaj   +1 more source

Characterization of Avian Influenza Virus H10–H12 Subtypes Isolated from Wild Birds in Shanghai, China from 2016 to 2019

Viruses, 2020
H10, H11 and H12 (H10–H12) subtypes of the avian influenza virus (AIV) are associated with waterfowl. Although these subtypes of AIV are infrequently detected in nature, they can undergo reassortment with other AIV subtypes.
Ling Tang, Wangjun Tang, Le Ming, Jianming Gu, Kai Qian, Xiaofang Li, Tianhou Wang, Guimei He   +7 more
doaj   +1 more source